4FZ0

Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at low pH

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ASICs transmembrane helices-like	8106434	3002854	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Proton-activated chloride channel extracellular domain-like	8106423	3002853	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Proton-activated chloride channel extracellular domain-like	8106423	3002853	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Proton-activated chloride channel extracellular domain-like	8106423	3002853	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ASICs transmembrane helices-like	8106433	3002854	SCOP2B (2022-06-29)
E [auth N]	SCOP2B Superfamily	omega toxin-like	8036232	3000255	SCOP2B (2022-06-29)
F [auth O]	SCOP2B Superfamily	omega toxin-like	8036232	3000255	SCOP2B (2022-06-29)
D [auth M]	SCOP2B Superfamily	omega toxin-like	8036232	3000255	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ASC	e4fz0A1	A: beta sandwiches	X: Amiloride-sensitive cation channel 2 (From Topology)	H: Amiloride-sensitive cation channel 2 (From Topology)	T: Amiloride-sensitive cation channel 2	F: ASC	ECOD (1.6)
B	ASC	e4fz0B1	A: beta sandwiches	X: Amiloride-sensitive cation channel 2 (From Topology)	H: Amiloride-sensitive cation channel 2 (From Topology)	T: Amiloride-sensitive cation channel 2	F: ASC	ECOD (1.6)
C	ASC	e4fz0C1	A: beta sandwiches	X: Amiloride-sensitive cation channel 2 (From Topology)	H: Amiloride-sensitive cation channel 2 (From Topology)	T: Amiloride-sensitive cation channel 2	F: ASC	ECOD (1.6)
E [auth N]	EUF08697	e4fz0N1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: EUF08697	ECOD (1.6)
F [auth O]	EUF08697	e4fz0O1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: EUF08697	ECOD (1.6)
D [auth M]	EUF08697	e4fz0M1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: EUF08697	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.770	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	YojJ-like	CATH (4.3.0)
A	2.60.470.10	Mainly Beta	Sandwich	Acid-sensing ion channels like fold	Acid-sensing ion channels like domains	CATH (4.3.0)
A	1.10.3590.10	Mainly Alpha	Orthogonal Bundle	acid-sensing ion channel 1 fold	acid-sensing ion channel 1 domain	CATH (4.3.0)
A	1.10.287.820	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Acid-sensing ion channel domain	CATH (4.3.0)
B	1.10.287.770	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	YojJ-like	CATH (4.3.0)
B	2.60.470.10	Mainly Beta	Sandwich	Acid-sensing ion channels like fold	Acid-sensing ion channels like domains	CATH (4.3.0)
B	1.10.3590.10	Mainly Alpha	Orthogonal Bundle	acid-sensing ion channel 1 fold	acid-sensing ion channel 1 domain	CATH (4.3.0)
B	1.10.287.820	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Acid-sensing ion channel domain	CATH (4.3.0)
C	1.10.287.770	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	YojJ-like	CATH (4.3.0)
C	2.60.470.10	Mainly Beta	Sandwich	Acid-sensing ion channels like fold	Acid-sensing ion channels like domains	CATH (4.3.0)
C	1.10.3590.10	Mainly Alpha	Orthogonal Bundle	acid-sensing ion channel 1 fold	acid-sensing ion channel 1 domain	CATH (4.3.0)
C	1.10.287.820	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Acid-sensing ion channel domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00858	Amiloride-sensitive sodium channel (ASC)	Amiloride-sensitive sodium channel	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Acid-sensing ion channel 1	monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity identical protein binding protein binding binding	protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis cellular response to stimulus response to stimulus response to pH protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis cellular response to stimulus response to stimulus response to pH cellular response to pH response to abiotic stimulus cellular response to abiotic stimulus cellular response to environmental stimulus transport monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport sodium ion transport	cell periphery plasma membrane membrane cellular anatomical entity
D [auth M], E [auth N], F [auth O]	Pi-theraphotoxin-Pc1a	channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity toxin activity	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR004724	Epithelial sodium channel, chordates	Family
A, B, C	IPR001873	Epithelial sodium channel	Family
A, B, C	IPR020903	Epithelial sodium channel, conserved site	Conserved Site

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM	Transmembrane	Alpha-helical polytopic	ENaC/P2X	Acid-sensing ion channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Other Ion Channels	ASIC1 Acid-Sensing Ion Channel in complex with psalmotoxin 1 (PcTx1), pH 5.5

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.