4FXY

Crystal structure of rat neurolysin with bound pyrazolidin inhibitor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth P]	d4fxyp_	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	Neurolysin-like	automated matches	rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth Q]	d4fxyq_	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	Neurolysin-like	automated matches	rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth P]	SCOP2B Superfamily	Metalloproteases (zincins) catalytic domain	8035465	3001975	SCOP2B (2022-06-29)
B [auth Q]	SCOP2B Superfamily	Metalloproteases (zincins) catalytic domain	8035465	3001975	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth P]	PF01432	e4fxyP1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: PF01432	ECOD (1.6)
B [auth Q]	PF01432	e4fxyQ1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: PF01432	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth P]	1.20.1050.40	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
A [auth P]	1.10.1370.10	Mainly Alpha	Orthogonal Bundle	Neurolysin	domain 3	CATH (4.3.0)
A [auth P]	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
B [auth Q]	1.20.1050.40	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
B [auth Q]	1.10.1370.10	Mainly Alpha	Orthogonal Bundle	Neurolysin	domain 3	CATH (4.3.0)
B [auth Q]	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth P], B [auth Q]	PF01432	Peptidase family M3 (Peptidase_M3)	Peptidase family M3	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth P], B [auth Q]	Neurolysin, mitochondrial	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity metalloendopeptidase activity metallopeptidase activity endopeptidase activity oligopeptidase activity binding peptide binding cation binding ion binding metal ion binding small molecule binding	organic substance metabolic process metabolic process peptide metabolic process cellular catabolic process catabolic process cellular metabolic process cellular process organic substance catabolic process peptide catabolic process monosaccharide metabolic process gluconeogenesis regulation of primary metabolic process regulation of small molecule metabolic process organic substance biosynthetic process organic substance metabolic process metabolic process peptide metabolic process cellular catabolic process catabolic process cellular metabolic process cellular process organic substance catabolic process peptide catabolic process monosaccharide metabolic process gluconeogenesis regulation of primary metabolic process regulation of small molecule metabolic process organic substance biosynthetic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process regulation of biosynthetic process carbohydrate metabolic process regulation of biological process small molecule biosynthetic process carbohydrate biosynthetic process biological regulation hexose metabolic process primary metabolic process monosaccharide biosynthetic process hexose biosynthetic process biosynthetic process regulation of gluconeogenesis regulation of carbohydrate biosynthetic process regulation of metabolic process glucose metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process protein catabolic process macromolecule catabolic process protein metabolic process macromolecule metabolic process skeletal muscle cell differentiation regulation of cellular process cellular developmental process regulation of developmental process skeletal muscle tissue development regulation of cell differentiation regulation of striated muscle cell differentiation muscle cell differentiation myotube differentiation muscle structure development skeletal muscle organ development regulation of skeletal muscle cell differentiation cell differentiation regulation of myotube differentiation anatomical structure development regulation of skeletal muscle fiber differentiation muscle tissue development muscle organ development developmental process animal organ development tissue development regulation of muscle cell differentiation skeletal muscle fiber differentiation striated muscle cell differentiation proteolysis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle mitochondrial intermembrane space mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle envelope lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle mitochondrial intermembrane space mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope organelle lumen organelle mitochondrial envelope

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth P], B [auth Q]	IPR024080	Neurolysin/Thimet oligopeptidase, N-terminal	Homologous Superfamily
A [auth P], B [auth Q]	IPR024079	Metallopeptidase, catalytic domain superfamily	Homologous Superfamily
A [auth P], B [auth Q]	IPR001567	Peptidase M3A/M3B catalytic domain	Domain
A [auth P], B [auth Q]	IPR024077	Neurolysin/Thimet oligopeptidase, domain 2	Homologous Superfamily
A [auth P], B [auth Q]	IPR045090	Peptidase M3A/M3B	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.