4FMN

Structure of the C-terminal domain of the Saccharomyces cerevisiae MUTL alpha (MLH1/PMS1) heterodimer bound to a fragment of NTG2

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DNA mismatch repair protein MutL	8053829	3001605	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF16413	e4fmnA1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: DNA mismatch repair protein MutL regulatory subdomain (From Topology)	T: DNA mismatch repair protein MutL regulatory subdomain	F: PF16413	ECOD (1.6)
A	PF16413	e4fmnA2	A: a+b two layers	X: DNA mismatch repair protein MutL dimerization subdomain (From Topology)	H: DNA mismatch repair protein MutL dimerization subdomain (From Topology)	T: DNA mismatch repair protein MutL dimerization subdomain	F: PF16413	ECOD (1.6)
B	F_UNCLASSIFIED	e4fmnB2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: DNA mismatch repair protein MutL regulatory subdomain (From Topology)	T: DNA mismatch repair protein MutL regulatory subdomain	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e4fmnB1	A: a+b two layers	X: DNA mismatch repair protein MutL dimerization subdomain (From Topology)	H: DNA mismatch repair protein MutL dimerization subdomain (From Topology)	T: DNA mismatch repair protein MutL dimerization subdomain	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16413	DNA mismatch repair protein Mlh1 C-terminus (Mlh1_C)	DNA mismatch repair protein Mlh1 C-terminus	This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site [1].	Domain
B	PF08676	MutL C terminal dimerisation domain (MutL_C)	MutL C terminal dimerisation domain	MutL and MutS are key components of the DNA repair machinery that corrects replication errors [1]. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The ...	MutL and MutS are key components of the DNA repair machinery that corrects replication errors [1]. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The N terminal region of MutL contains the ATPase domain and the C terminal is involved in dimerisation [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA mismatch repair protein MLH1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding double-stranded DNA binding mismatched DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA damage sensor activity catalytic activity, acting on DNA small molecule sensor activity ATP-dependent DNA damage sensor activity catalytic activity, acting on a nucleic acid	sexual reproduction reproductive process meiotic cell cycle DNA recombination primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process meiosis I cell cycle process meiotic heteroduplex formation cellular process sexual reproduction reproductive process meiotic cell cycle DNA recombination primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process meiosis I cell cycle process meiotic heteroduplex formation cellular process metabolic process cell cycle macromolecule metabolic process cell cycle process cellular response to stimulus mismatch repair response to stimulus meiotic mismatch repair cellular response to stress response to stress DNA repair DNA damage response homologous recombination cellular component organization meiosis I meiotic nuclear division cellular component organization or biogenesis reciprocal homologous recombination organelle fission reciprocal meiotic recombination nuclear division organelle organization	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex MutLalpha complex mismatch repair complex MutLgamma complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex MutLalpha complex mismatch repair complex MutLgamma complex MutLbeta complex
B	DNA mismatch repair protein PMS1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding double-stranded DNA binding mismatched DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA damage sensor activity catalytic activity, acting on DNA small molecule sensor activity ATP-dependent DNA damage sensor activity catalytic activity, acting on a nucleic acid	cellular response to stimulus mismatch repair sexual reproduction response to stimulus reproductive process meiotic cell cycle process meiotic mismatch repair nucleobase-containing compound metabolic process organic substance metabolic process cellular response to stress response to stress cell cycle cell cycle process DNA repair cellular response to stimulus mismatch repair sexual reproduction response to stimulus reproductive process meiotic cell cycle process meiotic mismatch repair nucleobase-containing compound metabolic process organic substance metabolic process cellular response to stress response to stress cell cycle cell cycle process DNA repair meiotic cell cycle primary metabolic process DNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process meiosis I cell cycle process DNA damage response cellular process metabolic process macromolecule metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle MutLalpha complex mismatch repair complex cytoplasm
C	DNA repair peptide	DNA binding binding organic cyclic compound binding nucleic acid binding DNA-(apurinic or apyrimidinic site) endonuclease activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid class I DNA-(apurinic or apyrimidinic site) endonuclease activity lyase activity catalytic activity carbon-oxygen lyase activity hydrolase activity, acting on glycosyl bonds oxidized base lesion DNA N-glycosylase activity hydrolase activity DNA binding binding organic cyclic compound binding nucleic acid binding DNA-(apurinic or apyrimidinic site) endonuclease activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid class I DNA-(apurinic or apyrimidinic site) endonuclease activity lyase activity catalytic activity carbon-oxygen lyase activity hydrolase activity, acting on glycosyl bonds oxidized base lesion DNA N-glycosylase activity hydrolase activity oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity DNA N-glycosylase activity hydrolase activity, hydrolyzing N-glycosyl compounds iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process base-excision repair organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process base-excision repair organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair base-excision repair, AP site formation	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038973	DNA mismatch repair protein MutL/Mlh/Pms-like	Family
A	IPR013507	DNA mismatch repair protein, S5 domain 2-like	Domain
A	IPR002099	DNA mismatch repair protein MutL/Mlh/PMS	Family
A	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A	IPR014762	DNA mismatch repair, conserved site	Conserved Site
A	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
A	IPR032189	DNA mismatch repair protein Mlh1, C-terminal	Domain
A	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
B	IPR038973	DNA mismatch repair protein MutL/Mlh/Pms-like	Family
B	IPR037198	MutL, C-terminal domain superfamily	Homologous Superfamily
B	IPR013507	DNA mismatch repair protein, S5 domain 2-like	Domain
B	IPR014790	MutL, C-terminal, dimerisation	Domain
B	IPR002099	DNA mismatch repair protein MutL/Mlh/PMS	Family
B	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
B	IPR042121	MutL, C-terminal domain, regulatory subdomain	Homologous Superfamily
B	IPR042120	MutL, C-terminal domain, dimerisation subdomain	Homologous Superfamily
B	IPR014762	DNA mismatch repair, conserved site	Conserved Site
B	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
B	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
C	IPR003265	HhH-GPD domain	Domain
C	IPR004036	Endonuclease III-like, conserved site-2	Conserved Site
C	IPR023170	Helix-hairpin-helix, base-excision DNA repair, C-terminal	Homologous Superfamily
C	IPR030841	Endonuclease III-like protein 1	Family
C	IPR011257	DNA glycosylase	Homologous Superfamily
C	IPR003651	Endonuclease III-like, iron-sulphur cluster loop motif	Conserved Site

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359