4FDG

Crystal Structure of an Archaeal MCM Filament

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF17207	e4fdgB3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
A [auth B]	PF17855	e4fdgB6	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
A [auth B]	PF14551	e4fdgB4	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
A [auth B]	PF00493	e4fdgB5	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
A [auth B]	F_UNCLASSIFIED	e4fdgB1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth A]	PF17207	e4fdgA2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
B [auth A]	PF17855	e4fdgA5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
B [auth A]	PF14551	e4fdgA7	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
B [auth A]	PF00493	e4fdgA4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
B [auth A]	F_UNCLASSIFIED	e4fdgA6	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF17207	e4fdgC2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
C	PF17855	e4fdgC5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
C	PF14551	e4fdgC7	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
C	PF00493	e4fdgC4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
C	F_UNCLASSIFIED	e4fdgC6	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF17207	e4fdgD2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
D	PF17855	e4fdgD5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
D	PF14551	e4fdgD7	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
D	PF00493	e4fdgD4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
D	F_UNCLASSIFIED	e4fdgD6	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF17207	e4fdgE2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
E	PF17855	e4fdgE5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
E	PF14551	e4fdgE7	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
E	PF00493	e4fdgE4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
E	F_UNCLASSIFIED	e4fdgE6	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A], C, D, E	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
A [auth B], B [auth A], C, D, E	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
A [auth B], B [auth A], C, D, E	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
A [auth B], B [auth A], C, D, E	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A], C, D, E	Minichromosome maintenance protein MCM	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides identical protein binding protein binding DNA binding single-stranded DNA binding nucleic acid binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular component organization DNA duplex unwinding organelle organization DNA geometric change chromosome organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular component organization DNA duplex unwinding organelle organization DNA geometric change chromosome organization cellular process DNA conformation change cellular component organization or biogenesis	protein-containing complex MCM complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A], C, D, E	IPR048908	Minichromosome maintenance protein MCM, C-terminal domain	Domain
A [auth B], B [auth A], C, D, E	IPR027925	MCM, N-terminal domain	Domain
A [auth B], B [auth A], C, D, E	IPR031327	Mini-chromosome maintenance protein	Family
A [auth B], B [auth A], C, D, E	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A [auth B], B [auth A], C, D, E	IPR033762	MCM OB domain	Domain
A [auth B], B [auth A], C, D, E	IPR003593	AAA+ ATPase domain	Domain
A [auth B], B [auth A], C, D, E	IPR001208	MCM domain	Domain
A [auth B], B [auth A], C, D, E	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A [auth B], B [auth A], C, D, E	IPR041562	MCM, AAA-lid domain	Domain
A [auth B], B [auth A], C, D, E	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

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4FDG

Crystal Structure of an Archaeal MCM Filament

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage