4F4O

Structure of the Haptoglobin-Haemoglobin Complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4f4oa_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, alpha-chain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
D	d4f4od_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, alpha-chain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
G	d4f4og_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, alpha-chain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
J	d4f4oj_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, alpha-chain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
E	d4f4oe_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, beta-chain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
H	d4f4oh_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, beta-chain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
K	d4f4ok_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, beta-chain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
B	d4f4ob_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, beta-chain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Globin-like	8036044	3000554	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Globin-like	8036044	3000554	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Globin-like	8036044	3000554	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Globin-like	8036044	3000554	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Globin-like	8036202	3000554	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Globin-like	8036202	3000554	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Globin-like	8036202	3000554	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Globin-like	8036202	3000554	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Sushi/CCP/SCR domain	8101062	3000902	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Trypsin-like serine proteases	8100244	3000114	SCOP2B (2022-06-29)
C	SCOP2 Family	Eukaryotic proteases	8100243	4000286	SCOP2 (2022-06-29)
C	SCOP2 Family	Sushi/CCP/SCR domain	8101061	4003458	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Trypsin-like serine proteases	8100244	3000114	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Sushi/CCP/SCR domain	8101062	3000902	SCOP2 (2022-06-29)
F	SCOP2B Superfamily	Sushi/CCP/SCR domain	8101062	3000902	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Trypsin-like serine proteases	8100244	3000114	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Sushi/CCP/SCR domain	8101062	3000902	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Trypsin-like serine proteases	8100244	3000114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Globin	e4f4oA1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
D	Globin	e4f4oD1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
G	Globin	e4f4oG1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
J	Globin	e4f4oJ1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
E	Globin	e4f4oE1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
H	Globin	e4f4oH1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
K	Globin	e4f4oK1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
B	Globin	e4f4oB1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
L	Trypsin_1	e4f4oL4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)
L	Sushi_3	e4f4oL3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_3	ECOD (1.6)
C	Trypsin_1	e4f4oC2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)
C	Sushi_3	e4f4oC1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_3	ECOD (1.6)
F	Trypsin_1	e4f4oF3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)
F	Sushi_3	e4f4oF4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_3	ECOD (1.6)
I	Trypsin_1	e4f4oI4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)
I	Sushi_3	e4f4oI3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
D	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
G	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
J	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
E	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
H	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
K	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
B	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
L	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
L	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
C	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
C	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
F	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
F	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
I	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
I	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D, G, J	PF00042	Globin (Globin)	Globin	-	Domain
B, E, H, K	PF00042	Globin (Globin)	Globin	-	Domain
C, F, I, L	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D, G, J	Hemoglobin subunit alpha	oxygen binding binding small molecule binding oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding organic acid binding	cellular catabolic process catabolic process cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular catabolic process catabolic process cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular oxidant detoxification cellular response to toxic substance response to toxic substance	protein-containing complex intracellular anatomical structure hemoglobin complex cytoplasm cellular anatomical entity cytosol haptoglobin-hemoglobin complex
B, E, H, K	Hemoglobin subunit beta	oxygen binding binding small molecule binding hemoglobin binding protein binding hemoglobin alpha binding oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding organic acid binding cation binding ion binding oxygen binding binding small molecule binding hemoglobin binding protein binding hemoglobin alpha binding oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding organic acid binding cation binding ion binding metal ion binding	cellular catabolic process catabolic process cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular catabolic process catabolic process cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular oxidant detoxification cellular response to toxic substance response to toxic substance	protein-containing complex intracellular anatomical structure hemoglobin complex cytoplasm cellular anatomical entity cytosol haptoglobin-hemoglobin complex
C, F, I, L	Haptoglobin	antioxidant activity hemoglobin binding protein binding binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	immune system process acute-phase response response to stimulus defense response response to stress inflammatory response acute inflammatory response biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium immune system process acute-phase response response to stimulus defense response response to stress inflammatory response acute inflammatory response biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus	extracellular region extracellular space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D, G, J	IPR002338	Hemoglobin, alpha-type	Family
A, D, G, J	IPR002339	Hemoglobin, pi	Family
A, D, G, J	IPR009050	Globin-like superfamily	Homologous Superfamily
A, D, G, J	IPR012292	Globin/Protoglobin	Homologous Superfamily
A, D, G, J	IPR000971	Globin	Domain
B, E, H, K	IPR009050	Globin-like superfamily	Homologous Superfamily
B, E, H, K	IPR012292	Globin/Protoglobin	Homologous Superfamily
B, E, H, K	IPR002337	Hemoglobin, beta-type	Family
B, E, H, K	IPR000971	Globin	Domain
C, F, I, L	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
C, F, I, L	IPR001314	Peptidase S1A, chymotrypsin family	Family
C, F, I, L	IPR001254	Serine proteases, trypsin domain	Domain
C, F, I, L	IPR008292	Haptoglobin	Family
C, F, I, L	IPR000436	Sushi/SCR/CCP domain	Domain
C, F, I, L	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
C, F, I, L	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.