4F21

Crystal structure of carboxylesterase/phospholipase family protein from Francisella tularensis

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4f21a1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
A	d4f21a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
B	d4f21b1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
B	d4f21b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
C	d4f21c1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
C	d4f21c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
D	d4f21d1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
D	d4f21d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
E	d4f21e1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
E	d4f21e2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
F	d4f21f1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
F	d4f21f2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
G	d4f21g1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
G	d4f21g2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
H	d4f21h1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	automated matches	automated matches	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)
H	d4f21h2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Francisella tularensis subsp. tularensis SCHU S4 ) [TaxId: 177416 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Carboxylesterase/thioesterase 1	8067288	4000719	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	alpha/beta-Hydrolases	8067289	3000102	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	alpha/beta-Hydrolases	8067289	3000102	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	alpha/beta-Hydrolases	8067289	3000102	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	alpha/beta-Hydrolases	8067289	3000102	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	alpha/beta-Hydrolases	8067289	3000102	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	alpha/beta-Hydrolases	8067289	3000102	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	alpha/beta-Hydrolases	8067289	3000102	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	alpha/beta-Hydrolases	8067289	3000102	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hydrolase_4	e4f21A1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
B	Hydrolase_4	e4f21B2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
C	Hydrolase_4	e4f21C2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
D	Hydrolase_4	e4f21D2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
E	Hydrolase_4	e4f21E2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
F	Hydrolase_4	e4f21F2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
G	Hydrolase_4	e4f21G2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
H	Hydrolase_4	e4f21H2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
C	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
D	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
E	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
F	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
G	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
H	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF02230	Phospholipase/Carboxylesterase (Abhydrolase_2)	Phospholipase/Carboxylesterase	This family consists of both phospholipases [1] and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases Pfam:PF00561 [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Carboxylesterase/phospholipase family protein	hydrolase activity catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR003140	Phospholipase/carboxylesterase/thioesterase	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.