Annotations: 4EWS

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LBP_BPI_CETP	e4ewsA1	A: a+b complex topology	X: Aha1/BPI domain-like (From Topology)	H: Aha1/BPI domain-like (From Topology)	T: Aha1/BPI domain-like	F: LBP_BPI_CETP	ECOD (1.6)
A	LBP_BPI_CETP_C	e4ewsA2	A: a+b complex topology	X: Aha1/BPI domain-like (From Topology)	H: Aha1/BPI domain-like (From Topology)	T: Aha1/BPI domain-like	F: LBP_BPI_CETP_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.15.20.10	Alpha Beta	Super Roll	Bactericidal permeability-increasing protein	domain 2	CATH (4.3.0)
A	3.15.10.10	Alpha Beta	Super Roll	Bactericidal permeability-increasing protein	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01273	LBP / BPI / CETP family, N-terminal domain (LBP_BPI_CETP)	LBP / BPI / CETP family, N-terminal domain	-	Family
A	PF02886	LBP / BPI / CETP family, C-terminal domain (LBP_BPI_CETP_C)	LBP / BPI / CETP family, C-terminal domain	The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CETP	sterol binding binding organic cyclic compound binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding lipid transporter activity transporter activity phospholipid transporter activity sterol transfer activity lipid transfer activity cholesterol transfer activity sterol binding binding organic cyclic compound binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding lipid transporter activity transporter activity phospholipid transporter activity sterol transfer activity lipid transfer activity cholesterol transfer activity cation binding ion binding phosphatidylcholine binding phospholipid binding quaternary ammonium group binding triglyceride binding	developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of developmental process macrophage derived foam cell differentiation biological regulation negative regulation of biological process regulation of cell differentiation negative regulation of macrophage derived foam cell differentiation foam cell differentiation cell differentiation negative regulation of cellular process regulation of macrophage derived foam cell differentiation developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of developmental process macrophage derived foam cell differentiation biological regulation negative regulation of biological process regulation of cell differentiation negative regulation of macrophage derived foam cell differentiation foam cell differentiation cell differentiation negative regulation of cellular process regulation of macrophage derived foam cell differentiation negative regulation of cell differentiation cellular process plasma lipoprotein particle organization multicellular organismal process low-density lipoprotein particle remodeling protein-containing complex organization protein-containing complex remodeling protein-lipid complex organization plasma lipoprotein particle remodeling regulation of plasma lipoprotein particle levels cellular component organization protein-lipid complex remodeling cellular component organization or biogenesis phospholipid homeostasis chemical homeostasis homeostatic process lipid homeostasis transport organic substance transport reverse cholesterol transport lipid localization lipid transport organic hydroxy compound transport establishment of localization localization macromolecule localization cholesterol transport sterol transport triglyceride homeostasis acylglycerol homeostasis organonitrogen compound metabolic process cellular metabolic process glycerophospholipid metabolic process primary metabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphatidylcholine metabolic process metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process triglyceride-rich lipoprotein particle remodeling very-low-density lipoprotein particle remodeling sterol homeostasis cholesterol homeostasis organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process alcohol metabolic process organic cyclic compound metabolic process secondary alcohol metabolic process small molecule metabolic process regulation of sterol transport regulation of localization regulation of transport regulation of lipid transport regulation of lipid localization regulation of cholesterol efflux regulation of cholesterol transport cholesterol efflux high-density lipoprotein particle remodeling neutral lipid metabolic process triglyceride metabolic process acylglycerol metabolic process positive regulation of sterol transport positive regulation of biological process positive regulation of cholesterol transport positive regulation of lipid localization positive regulation of lipid transport positive regulation of transport regulation of phospholipid transport phospholipid transport positive regulation of phospholipid transport organophosphate ester transport acylglycerol transport triglyceride transport	membrane-bounded organelle organelle cellular anatomical entity vesicle protein-containing complex extracellular region plasma lipoprotein particle high-density lipoprotein particle extracellular space lipoprotein particle protein-lipid complex extracellular exosome extracellular vesicle extracellular organelle membrane-bounded organelle organelle cellular anatomical entity vesicle protein-containing complex extracellular region plasma lipoprotein particle high-density lipoprotein particle extracellular space lipoprotein particle protein-lipid complex extracellular exosome extracellular vesicle extracellular organelle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017943	Bactericidal permeability-increasing protein, alpha/beta domain superfamily	Homologous Superfamily
A	IPR017942	Lipid-binding serum glycoprotein, N-terminal	Domain
A	IPR017130	Cholesteryl ester transfer	Family
A	IPR017954	Lipid-binding serum glycoprotein, conserved site	Conserved Site
A	IPR001124	Lipid-binding serum glycoprotein, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P11597	atherosclerosis cholesterol-ester transfer protein deficiency hypertriglyceridemia metabolic syndrome X age-related macular degeneration familial hypercholesterolemia hypertensive disorder cardiovascular disease Pediatric Obesity large cell medulloblastoma ovarian cancer peripheral nervous system disease wet macular degeneration heart disease hyperalphalipoproteinemia atherosclerosis cholesterol-ester transfer protein deficiency hypertriglyceridemia metabolic syndrome X age-related macular degeneration familial hypercholesterolemia hypertensive disorder cardiovascular disease Pediatric Obesity large cell medulloblastoma ovarian cancer peripheral nervous system disease wet macular degeneration heart disease hyperalphalipoproteinemia hyperlipidemia inherited lipid metabolism disorder nephrosclerosis pancreatic ductal adenocarcinoma peripheral neuropathy ductal breast carcinoma in situ hepatocellular carcinoma hyperlipoproteinemia interstitial cystitis macular degeneration arteriosclerosis disorder osteosarcoma coronary artery disease retinal degeneration familial hyperlipidemia

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.