4EHC

Crystal structure of the C-terminal domain of Rv0977 of Mycobacterium tuberculosis

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF20729	e4ehcA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: PF20729	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF20729	PE-PGRS C-terminal aspartyl peptidase-like domain (PE-PGRS_C)	PE-PGRS C-terminal aspartyl peptidase-like domain	This domain is found at the C-terminus of some PE-PGRS proteins from Mycobacteria. The domain is related to aspartyl peptidases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PE-PGRS FAMILY PROTEIN	aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity aspartic-type endopeptidase activity catalytic activity endopeptidase activity cation binding ion binding binding metal ion binding small molecule binding	-	cell surface cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000084	PE-PGRS family, N-terminal	Domain
A	IPR048054	PE cleavage protein A, C-terminal domain	Domain
A	IPR048996	PGRS repeats	Repeat
A	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.