4EGR

2.50 angstrom resolution structure of 3-phosphoshikimate 1-carboxyvinyltransferase (AroA) from Coxiella burnetii in complex with phosphoenolpyruvate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4egra1	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
A	d4egra2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
B	d4egrb1	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
B	d4egrb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
C	d4egrc1	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
C	d4egrc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
D	d4egrd1	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
D	d4egrd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
E	d4egre1	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
E	d4egre2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
F	d4egrf1	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
F	d4egrf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EPT/RTPC-like	8074706	3001530	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EPT/RTPC-like	8074706	3001530	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	EPT/RTPC-like	8074706	3001530	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	EPT/RTPC-like	8074706	3001530	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	EPT/RTPC-like	8074706	3001530	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	EPT/RTPC-like	8074706	3001530	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00275	e4egrA2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: PF00275	ECOD (1.6)
B	PF00275	e4egrB2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: PF00275	ECOD (1.6)
C	PF00275	e4egrC1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: PF00275	ECOD (1.6)
D	PF00275	e4egrD2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: PF00275	ECOD (1.6)
E	PF00275	e4egrE1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: PF00275	ECOD (1.6)
F	PF00275	e4egrF1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: PF00275	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
B	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
C	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
D	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
E	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
F	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00275	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) (EPSP_synthase)	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	3-phosphoshikimate 1-carboxyvinyltransferase	3-phosphoshikimate 1-carboxyvinyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity	amino acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process amino acid metabolic process primary metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process organic acid biosynthetic process amino acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process amino acid metabolic process primary metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process chorismate metabolic process chorismate biosynthetic process small molecule metabolic process cellular process dicarboxylic acid biosynthetic process organonitrogen compound metabolic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process organonitrogen compound biosynthetic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001986	Enolpyruvate transferase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR013792	RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR036968	Enolpyruvate transferase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR006264	3-phosphoshikimate 1-carboxyvinyltransferase	Family
A, B, C, D, E A, B, C, D, E, F	IPR023193	3-phosphoshikimate 1-carboxyvinyltransferase, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.