4EDN

Crystal structure of beta-parvin CH2 domain in complex with paxillin LD1 motif

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CH	e4ednA2	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)
B	CH	e4ednB2	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)
C	CH	e4ednC2	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)
D	CH	e4ednD2	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)
E	CH	e4ednE2	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)
G	CH	e4ednG2	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)
H	CH	e4ednH2	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)
I	CH	e4ednI2	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)
J	CH	e4ednJ2	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)
F	CH	e4ednF2	A: alpha bundles	X: CH domain-like	H: Calponin-homology domain-like (From Topology)	T: Calponin-homology domain-like	F: CH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)
B	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)
C	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)
D	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)
E	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)
G	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)
H	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)
I	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)
J	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)
F	1.10.418.10	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF00307	Calponin homology (CH) domain (CH)	Calponin homology (CH) domain	The CH domain is found in both cytoskeletal proteins and signal transduction proteins [1]. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its ac ...	The CH domain is found in both cytoskeletal proteins and signal transduction proteins [1]. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity [4]. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin and Swiss:P15498 have only a single copy.	Domain
K, L, M, N, O K, L, M, N, O, P, Q	PF03535	Paxillin family (Paxillin)	Paxillin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Beta-parvin	cytoskeletal protein binding actin binding protein binding binding	cellular component biogenesis cellular component organization cellular component assembly cell projection organization cellular process cellular component organization or biogenesis cell projection assembly lamellipodium assembly plasma membrane bounded cell projection organization plasma membrane bounded cell projection assembly lamellipodium organization establishment or maintenance of cell polarity cell adhesion substrate adhesion-dependent cell spreading cellular component biogenesis cellular component organization cellular component assembly cell projection organization cellular process cellular component organization or biogenesis cell projection assembly lamellipodium assembly plasma membrane bounded cell projection organization plasma membrane bounded cell projection assembly lamellipodium organization establishment or maintenance of cell polarity cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization developmental process regulation of biological process regulation of developmental process establishment or maintenance of cell polarity regulating cell shape biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium intracellular anatomical structure Z disc sarcomere intracellular organelle I band anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cytoskeleton actin cytoskeleton cytosol cell periphery plasma membrane membrane
K, L, M, N, O K, L, M, N, O, P, Q	Paxillin	cytoskeletal protein binding protein binding binding vinculin binding protein phosphatase binding phosphatase binding enzyme binding signaling receptor binding neuropilin binding beta-catenin binding cation binding ion binding metal ion binding small molecule binding	epithelium migration multicellular organismal process tissue migration endothelial cell migration ameboidal-type cell migration epithelial cell migration cell migration cellular process cell motility cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cellular response to stimulus regulation of biological process epithelium migration multicellular organismal process tissue migration endothelial cell migration ameboidal-type cell migration epithelial cell migration cell migration cellular process cell motility cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication cellular response to nitrogen compound response to organic substance response to peptide hormone cellular response to growth hormone stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone cellular response to organic substance enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus growth hormone receptor signaling pathway cell surface receptor signaling pathway response to endogenous stimulus response to organonitrogen compound cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to growth hormone cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to oxidative stress cellular response to chemical stress response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress cellular response to stress response to stress regulation of signaling protein-containing complex organization regulation of signal transduction cellular component organization cellular component biogenesis signal complex assembly cellular component assembly regulation of response to stimulus protein-containing complex assembly regulation of cell communication cellular component organization or biogenesis positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process positive regulation of cellular component organization positive regulation of biological process regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly actin filament-based process stress fiber assembly positive regulation of cellular process regulation of actin filament organization actin cytoskeleton organization actomyosin structure organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization actin filament organization regulation of cellular component biogenesis positive regulation of supramolecular fiber organization regulation of organelle organization regulation of stress fiber assembly organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery cell cortex intracellular anatomical structure cytoplasm cell-cell junction anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery cell cortex intracellular anatomical structure cytoplasm cell-cell junction cytosol plasma membrane membrane actin filament bundle actin cytoskeleton actomyosin intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle stress fiber contractile actin filament bundle non-membrane-bounded organelle protein-containing complex microtubule associated complex microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR028433	Parvin	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR036872	CH domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR001715	Calponin homology domain	Domain
K, L, M, N, O K, L, M, N, O, P, Q	IPR001904	Paxillin, Lim domain 4	Domain
K, L, M, N, O K, L, M, N, O, P, Q	IPR047072	Paxillin, Lim domain 2	Domain
K, L, M, N, O K, L, M, N, O, P, Q	IPR001781	Zinc finger, LIM-type	Domain
K, L, M, N, O K, L, M, N, O, P, Q	IPR047075	Paxillin/TGFB1I1, LIM domain 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Pharos: Q9HBI1	acne dermatomyositis interstitial cystitis oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma spina bifida alcoholic liver cirrhosis glioblastoma malignant glioma osteosarcoma psoriasis ulcerative colitis Alzheimer disease hepatocellular carcinoma non-alcoholic fatty liver disease acne dermatomyositis interstitial cystitis oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma spina bifida alcoholic liver cirrhosis glioblastoma malignant glioma osteosarcoma psoriasis ulcerative colitis Alzheimer disease hepatocellular carcinoma non-alcoholic fatty liver disease ovarian cancer rheumatoid arthritis
K, L, M, N, O K, L, M, N, O, P, Q	Pharos: P49023	non-small cell lung carcinoma Neoplasm Metastasis attention deficit hyperactivity disorder, inattentive type glioblastoma cancer malignant ependymoma osteosarcoma malignant glioma polycystic ovary syndrome

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
K, L, M, N, O K, L, M, N, O, P, Q	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359
K, L, M, N, O K, L, M, N, O, P, Q	NH2	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 , AA0081 , AA0083 , AA0084 , AA0086 , AA0087 , AA0088 , AA0090 , AA0091 , AA0092 , AA0093 , AA0095 , AA0096 , AA0097 , AA0098 , AA0099 , AA0100 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359 , L-alanine amide MOD:00090 , L-asparagine amide MOD:00092 , L-aspartic acid 1-amide MOD:00093 , L-glutamine amide MOD:00095 , L-glutamic acid 1-amide MOD:00096 , glycine amide MOD:00097 , L-isoleucine amide MOD:00099 , L-leucine amide MOD:00100 , L-lysine amide MOD:00101 , L-methionine amide MOD:00102 , L-proline amide MOD:00104 , L-serine amide MOD:00105 , L-threonine amide MOD:00106 , L-tryptophan amide MOD:00107 , L-tyrosine amide MOD:00108 , L-valine amide MOD:00109

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.