4E8U

Crystal structure of Arabidopsis IDN2 XS domain along with a small segment of adjacent coiled-coil region

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03468	e4e8uA1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF03468	ECOD (1.6)
B [auth C]	PF03468	e4e8uC1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF03468	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.70.2890	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	XS domain	CATH (4.3.0)
B [auth C]	3.30.70.2890	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	XS domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C]	PF03468	XS domain (XS)	XS domain	The XS (rice gene X and SGS3) domain is found in a family of plant proteins including gene X Swiss:Q9SBW2 and SGS3 Swiss:Q9LDX1. SGS3 is thought to be involved in post-transcriptional gene silencing (PTGS). This domain contains a conserved aspartate ...	The XS (rice gene X and SGS3) domain is found in a family of plant proteins including gene X Swiss:Q9SBW2 and SGS3 Swiss:Q9LDX1. SGS3 is thought to be involved in post-transcriptional gene silencing (PTGS). This domain contains a conserved aspartate residue that may be functionally important. The XS domain has recently been predicted to possess an RRM-like RNA-binding domain [1] by fold recognition.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C]	Putative uncharacterized protein T8P19.180	RNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process DNA methylation-dependent heterochromatin formation chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process DNA methylation-dependent heterochromatin formation chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulatory ncRNA-mediated gene silencing regulation of gene expression negative regulation of gene expression regulatory ncRNA-mediated heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process cellular process facultative heterochromatin formation gene silencing by siRNA-directed DNA methylation macromolecule metabolic process regulation of metabolic process cellular response to stimulus regulation of DNA recombination regulation of double-strand break repair response to stimulus regulation of cellular response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process cellular response to stress response to stress regulation of response to stress recombinational repair regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination DNA repair double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process regulation of DNA repair regulation of double-strand break repair via homologous recombination organic cyclic compound metabolic process DNA damage response regulation of response to stimulus regulation of DNA metabolic process response to metal ion response to chemical response to cadmium ion response to inorganic substance	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C]	IPR005380	XS domain	Domain
A, B [auth C]	IPR038588	XS domain superfamily	Homologous Superfamily
A, B [auth C]	IPR005381	Zinc finger-XS domain	Domain
A, B [auth C]	IPR045177	Factor of DNA methylation 1-5/IDN2	Family
A, B [auth C]	IPR005379	Factor of DNA methylation 1-5/IDN2 , domain XH	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.