4DY7
Crystal structures of protease nexin-1 in complex with S195A thrombin
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | d4dy7c_ | Multi-domain proteins (alpha and beta) | Serpins | Serpins | automated matches | automated matches | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
F | d4dy7f_ | Multi-domain proteins (alpha and beta) | Serpins | Serpins | automated matches | automated matches | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B | SCOP2B Superfamily | Trypsin-like serine proteases | 8042154 | 3000114 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Trypsin-like serine proteases | 8042154 | 3000114 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Serpins | 8070197 | 3001563 | SCOP2B (2022-06-29) |
F | SCOP2 Family | Serpins | 8070196 | 4002658 | SCOP2 (2022-06-29) |
F | SCOP2 Superfamily | Serpins | 8070197 | 3001563 | SCOP2 (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | Serpin | e4dy7C1 | A: a+b complex topology | X: Serpins (From Topology) | H: Serpins (From Topology) | T: Serpins | F: Serpin | ECOD (1.6) |
F | Serpin | e4dy7F1 | A: a+b complex topology | X: Serpins (From Topology) | H: Serpins (From Topology) | T: Serpins | F: Serpin | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 4.10.140.10 | Few Secondary Structures | Irregular | Epsilon-Thrombin | Chain L | CATH (4.3.0) |
B | 2.40.10.10 | Mainly Beta | Beta Barrel | Thrombin, subunit H | Trypsin-like serine proteases | CATH (4.3.0) |
E | 2.40.10.10 | Mainly Beta | Beta Barrel | Thrombin, subunit H | Trypsin-like serine proteases | CATH (4.3.0) |
C | 3.30.497.10 | Alpha Beta | 2-Layer Sandwich | Antithrombin | Chain I, domain 2 | CATH (4.3.0) |
C | 2.30.39.10 | Mainly Beta | Roll | Alpha-1-antitrypsin | domain 1 | CATH (4.3.0) |
F | 3.30.497.10 | Alpha Beta | 2-Layer Sandwich | Antithrombin | Chain I, domain 2 | CATH (4.3.0) |
F | 2.30.39.10 | Mainly Beta | Roll | Alpha-1-antitrypsin | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF09396 | Thrombin light chain (Thrombin_light) | Thrombin light chain | Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII. Prothrombin is activated on the surface of a phospholipid membrane where factor Xa removes the activation peptide and cleave ... | Domain | |
PF00089 | Trypsin (Trypsin) | Trypsin | - | Domain | |
PF00079 | Serpin (serine protease inhibitor) (Serpin) | Serpin (serine protease inhibitor) | Structure is a multi-domain fold containing a bundle of helices and a beta sandwich. | Domain |