4DS1

The Structure of a Yeast Dyn2-Nup159 Complex and the Molecular Basis for the Dynein Light Chain - Nuclear Pore Interaction

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DLC	8082846	4001121	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DLC-like	8082847	3000821	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	DLC-like	8082847	3000821	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01221	e4ds1A1	A: a+b two layers	X: DLC (From Topology)	H: DLC (From Topology)	T: DLC	F: PF01221	ECOD (1.6)
C	PF01221	e4ds1C1	A: a+b two layers	X: DLC (From Topology)	H: DLC (From Topology)	T: DLC	F: PF01221	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.740.10	Alpha Beta	2-Layer Sandwich	Protein Inhibitor Of Neuronal Nitric Oxide Synthase	Protein Inhibitor Of Neuronal Nitric Oxide Synthase	CATH (4.3.0)
C	3.30.740.10	Alpha Beta	2-Layer Sandwich	Protein Inhibitor Of Neuronal Nitric Oxide Synthase	Protein Inhibitor Of Neuronal Nitric Oxide Synthase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF01221	Dynein light chain type 1 (Dynein_light)	Dynein light chain type 1	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Dynein light chain 1, cytoplasmic	protein-containing complex binding binding protein binding dynein intermediate chain binding	establishment of organelle localization cellular localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle cellular component organization localization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle establishment of organelle localization cellular localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle cellular component organization localization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle cellular component organization or biogenesis microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of localization establishment of cell polarity organelle organization mitotic cell cycle process establishment of mitotic spindle orientation cellular process microtubule-based process cytoskeleton organization RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport organelle transport along microtubule nucleus localization intracellular transport nuclear migration along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement nuclear migration protein localization establishment of protein localization protein transport cellular macromolecule localization nucleocytoplasmic transport nuclear transport nuclear pore organization protein-containing complex organization pore complex assembly cellular component biogenesis nuclear pore complex assembly nucleus organization cellular component assembly protein-containing complex assembly	peroxisomal importomer complex protein-containing complex transporter complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system membrane-enclosed lumen peroxisomal importomer complex protein-containing complex transporter complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen polymeric cytoskeletal fiber cytoplasmic microtubule cytoskeleton intracellular non-membrane-bounded organelle cytoplasm supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle nuclear protein-containing complex nuclear pore cytoplasmic dynein complex catalytic complex dynein complex microtubule associated complex
B, D	Nucleoporin NUP159	transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity binding nucleotide binding adenyl-nucleotide exchange factor activity ATPase regulator activity nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding molecular function regulator activity transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity binding nucleotide binding adenyl-nucleotide exchange factor activity ATPase regulator activity nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding molecular function regulator activity heterocyclic compound binding small molecule binding structural molecule activity structural constituent of nuclear pore	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process nuclear transport mRNA transport organic substance metabolic process mRNA export from nucleus establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport cellular metabolic process nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization metabolic process macromolecule metabolic process protein localization establishment of protein localization NLS-bearing protein import into nucleus import into nucleus cellular macromolecule localization protein import into nucleus protein localization to nucleus establishment of protein localization to organelle protein transport protein localization to organelle intracellular protein transport establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus cellular component biogenesis ribosome biogenesis ribosomal small subunit export from nucleus organelle localization ribosome localization protein export from nucleus ribosomal large subunit export from nucleus	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel nuclear pore cytoplasmic filaments

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR037177	Dynein light chain superfamily	Homologous Superfamily
A, C	IPR001372	Dynein light chain, type 1/2	Family
A, C	IPR019763	Dynein light chain, type 1/2, conserved site	Conserved Site
B, D	IPR039462	Nucleoporin Nup159/Nup146, N-terminal	Domain
B, D	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.