Annotations: 4DGW

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Prp9-like	8046221	4004965	SCOP2 (2022-06-29)
A	SCOP2 Family	HkH motif-containing C2H2 finger	8047131	4003065	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Prp9-like	8046394	3002670	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	beta-beta-alpha zinc fingers	8093057	3001077	SCOP2 (2022-06-29)
B	SCOP2 Family	Prp21-like	8047359	4005605	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Prp21-like	8093059	3002671	SCOP2 (2022-06-29)
C	SCOP2 Family	Prp11-like	8046219	4004963	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Hsp20 chaperone-like	8093058	3001242	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PRP9_N	e4dgwA1	A: alpha bundles	X: Pre-mRNA-splicing factor PRP9 (From Topology)	H: Pre-mRNA-splicing factor PRP9 (From Topology)	T: Pre-mRNA-splicing factor PRP9	F: PRP9_N	ECOD (1.6)
B	PRP21_like_P	e4dgwB1	A: alpha bundles	X: Surp module (SWAP domain) (From Topology)	H: Surp module (SWAP domain) (From Topology)	T: Surp module (SWAP domain)	F: PRP21_like_P	ECOD (1.6)
C	SF3A2	e4dgwC1	A: beta sandwiches	X: HSP20-like	H: Pre-mRNA-splicing factor PRP11 C-terminal domain (From Topology)	T: Pre-mRNA-splicing factor PRP11 C-terminal domain	F: SF3A2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.10.790	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Surp module	CATH (4.3.0)
B	6.10.250.1320	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	2.60.40.2690	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16958	Pre-mRNA-splicing factor PRP9 N-terminus (PRP9_N)	Pre-mRNA-splicing factor PRP9 N-terminus	This is the N-terminal domain of pre-mRNA-splicing factor PRP9 [1].	Domain
A	PF16837	Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 (SF3A3)	Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9	SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp2 ...	SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp21 (subunit 1). Prp9 and Prp21 were not thought to interact with each other but the alpha1 helix of Prp9 does make important contacts with the SURP2 domain of Prp21, thus the two do interact via a bidentate-binding mode. Prp9 harbours a major binding site for stem-loop IIa of U2 snRNA [1].	Domain
A	PF12171	Zinc-finger double-stranded RNA-binding (zf-C2H2_jaz)	Zinc-finger double-stranded RNA-binding	-	Family
B	PF12230	Pre-mRNA splicing factor PRP21 like protein (PRP21_like_P)	Pre-mRNA splicing factor PRP21 like protein	-	Family
B	PF01805	Surp module (Surp)	Surp module	-	Family
C	PF16835	Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) (SF3A2)	Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)	SF3A2 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp2 ...	SF3A2 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp21 (subunit 1). with Prp21 wrapping around Prp11 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Pre-mRNA-splicing factor PRP9	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis spliceosomal complex assembly organic substance metabolic process protein-RNA complex organization cellular component assembly organic substance biosynthetic process protein-containing complex assembly ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis spliceosomal complex assembly organic substance metabolic process protein-RNA complex organization cellular component assembly organic substance biosynthetic process protein-containing complex assembly RNA processing cellular component organization or biogenesis mRNA splice site recognition RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process mRNA 5'-splice site recognition gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process U2-type prespliceosome assembly	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP spliceosomal complex U2-type spliceosomal complex prespliceosome U2-type prespliceosome
B	Pre-mRNA-splicing factor PRP21	RNA binding binding organic cyclic compound binding nucleic acid binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex U2-type spliceosomal complex prespliceosome U2-type prespliceosome
C	Pre-mRNA-splicing factor PRP11	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process U2-type prespliceosome assembly	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex U2-type spliceosomal complex prespliceosome U2-type prespliceosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger	Domain
A	IPR013087	Zinc finger C2H2-type	Domain
A	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
A	IPR031590	Pre-mRNA-splicing factor Prp9, N-terminal	Domain
A	IPR031774	SF3A3 domain	Domain
A	IPR024598	Splicing factor SF3a60 /Prp9 subunit, C-terminal	Domain
A	IPR000690	Matrin/U1-C, C2H2-type zinc finger	Domain
A	IPR022755	Zinc finger, double-stranded RNA binding	Domain
B	IPR045146	Splicing factor 3A subunit 1	Family
B	IPR035967	SWAP/Surp superfamily	Homologous Superfamily
B	IPR000061	SWAP/Surp	Domain
B	IPR022030	Splicing factor 3A subunit 1, conserved domain	Domain
C	IPR031781	SF3A2 domain	Domain
C	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger	Domain
C	IPR013087	Zinc finger C2H2-type	Domain
C	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.