4DEY

Crystal structure of the Voltage Dependent Calcium Channel beta-2 Subunit in Complex With The CaV1.2 I-II Linker.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d4deya1	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	SH3-like domain of the L-type calcium channel	European rabbit,Japanese white rabbit,domestic rabbit,rabbits (Oryctolagus cuniculus ) [TaxId: 9986 ], European rabbit,Japanese white rabbit,domestic rabbit,rabbits (Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)
B [auth A]	d4deya2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Nucleotide and nucleoside kinases	Guanylate kinase-like domain of the L-type calcium channel	European rabbit,Japanese white rabbit,domestic rabbit,rabbits (Oryctolagus cuniculus ) [TaxId: 9986 ], European rabbit,Japanese white rabbit,domestic rabbit,rabbits (Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2B Superfamily	SH3-domain	8058012	3000153	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8058013	3002021	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	PF12052	e4deyA4	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF12052	ECOD (1.6)
B [auth A]	PF00625	e4deyA3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00625	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
B [auth A]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A]	PF00625	Guanylate kinase (Guanylate_kin)	Guanylate kinase	-	Domain
B [auth A]	PF12052	Voltage gated calcium channel subunit beta domain 4Aa N terminal (VGCC_beta4Aa_N)	Voltage gated calcium channel subunit beta domain 4Aa N terminal	The beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal do ...	The beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal domain. It is made up of an alpha helix and a beta strand. It is thought to regulate the channel properties through protein-protein interactions with non Ca channel proteins. [1]	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Voltage-dependent L-type calcium channel subunit alpha-1C	calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity high voltage-gated calcium channel activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity protein binding binding calmodulin binding cation binding ion binding metal ion binding small molecule binding	positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transport into cytosol calcium ion transmembrane transport regulation of action potential regulation of biological process regulation of membrane repolarization during action potential membrane repolarization regulation of membrane repolarization action potential membrane repolarization during action potential regulation of membrane potential calcium ion transmembrane transport via high voltage-gated calcium channel positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of catalytic activity positive regulation of catalytic activity positive regulation of molecular function regulation of molecular function regulation of lyase activity regulation of adenylate cyclase activity regulation of cyclase activity positive regulation of lyase activity heart process multicellular organismal process system process regulation of heart contraction regulation of system process circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction blood circulation cellular response to stimulus regulation of calcium ion transport regulation of localization regulation of cellular process intracellular calcium ion homeostasis response to stimulus negative regulation of biological process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cardiac muscle contraction intracellular signal transduction cell communication intracellular signaling cassette signal transduction monoatomic cation homeostasis intracellular monoatomic ion homeostasis release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport regulation of cardiac muscle contraction muscle contraction maintenance of location release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis regulation of striated muscle contraction calcium-mediated signaling regulation of muscle contraction cellular localization inorganic ion homeostasis homeostatic process signaling calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion maintenance of location in cell striated muscle contraction regulation of calcium ion transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion regulation of cardiac muscle contraction by calcium ion signaling regulation of transport sequestering of calcium ion muscle system process regulation of muscle system process cellular homeostasis regulation of monoatomic cation transmembrane transport regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex cellular anatomical entity transporter complex cell periphery transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex cellular anatomical entity transporter complex cell periphery transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex postsynaptic specialization membrane postsynaptic specialization synapse postsynaptic density membrane synaptic membrane postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region somatodendritic compartment cell body perikaryon neuronal cell body cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection
B [auth A]	Voltage-dependent L-type calcium channel subunit beta-2	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity high voltage-gated calcium channel activity voltage-gated calcium channel activity involved in cardiac muscle cell action potential voltage-gated calcium channel activity involved in AV node cell action potential	heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling regulation of heart contraction regulation of system process cell-cell signaling involved in cardiac conduction membrane depolarization during cardiac muscle cell action potential cardiac muscle contraction striated muscle contraction cell communication circulatory system process actin filament-based process heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling regulation of heart contraction regulation of system process cell-cell signaling involved in cardiac conduction membrane depolarization during cardiac muscle cell action potential cardiac muscle contraction striated muscle contraction cell communication circulatory system process actin filament-based process regulation of multicellular organismal process regulation of biological quality atrial cardiac muscle cell to AV node cell communication cell communication involved in cardiac conduction blood circulation cardiac muscle cell contraction regulation of biological process atrial cardiac muscle cell action potential membrane depolarization during action potential biological regulation cell-cell signaling action potential actin filament-based movement muscle contraction muscle system process regulation of blood circulation membrane depolarization during atrial cardiac muscle cell action potential cardiac conduction membrane depolarization cellular process actin-mediated cell contraction heart contraction cardiac muscle cell action potential regulation of membrane potential regulation of localization regulation of calcium ion transport positive regulation of calcium ion transport transport regulation of transport regulation of monoatomic ion transport positive regulation of biological process establishment of localization calcium ion transport metal ion transport localization positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport calcium ion import trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling chemical synaptic transmission sensory perception of light stimulus sensory perception nervous system process visual perception regulation of heart rate by cardiac conduction regulation of heart rate	protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex cellular anatomical entity transporter complex cell periphery transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex protein-containing complex plasma membrane protein complex sarcolemma voltage-gated calcium channel complex plasma membrane membrane membrane protein complex cation channel complex cellular anatomical entity transporter complex cell periphery transmembrane transporter complex T-tubule L-type voltage-gated calcium channel complex calcium channel complex monoatomic ion channel complex photoreceptor ribbon synapse synapse cell junction ribbon synapse presynapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR014873	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain	Domain
A [auth B]	IPR002077	Voltage-dependent calcium channel, alpha-1 subunit	Family
A [auth B]	IPR031649	Voltage-dependent L-type calcium channel, IQ-associated domain	Domain
A [auth B]	IPR005451	Voltage-dependent calcium channel, L-type, alpha-1C subunit	Family
A [auth B]	IPR005821	Ion transport domain	Domain
A [auth B]	IPR005446	Voltage-dependent calcium channel, L-type, alpha-1 subunit	Family
A [auth B]	IPR031688	Voltage-gated calcium channel subunit alpha, C-terminal	Domain
A [auth B]	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily
B [auth A]	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
B [auth A]	IPR005444	Voltage-dependent calcium channel, L-type, beta-2 subunit	Family
B [auth A]	IPR035605	CACNB2, SH3 domain	Domain
B [auth A]	IPR001452	SH3 domain	Domain
B [auth A]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
B [auth A]	IPR046937	Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain	Domain
B [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth A]	IPR000584	Voltage-dependent calcium channel, L-type, beta subunit	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.