4DEP

Structure of the IL-1b signaling complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4depa_	All beta proteins	beta-Trefoil	Cytokine	Interleukin-1 (IL-1)	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4depd1	All beta proteins	beta-Trefoil	Cytokine	Interleukin-1 (IL-1)	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4depd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4depb1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d4depe1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cytokine	8043267	3000648	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cytokine	8043267	3000648	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054779	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055560	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055562	3000071	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054779	3000071	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055562	3000071	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055560	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00340	e4depA1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF00340	ECOD (1.6)
D	PF00340	e4depD1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF00340	ECOD (1.6)
B	PF13895	e4depB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13895	ECOD (1.6)
B	PF13927	e4depB3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)
B	PF18452	e4depB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF18452	ECOD (1.6)
E	PF13895	e4depE8	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13895	ECOD (1.6)
E	PF13927	e4depE7	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)
E	PF18452	e4depE9	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF18452	ECOD (1.6)
C	PF13895	e4depC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13895	ECOD (1.6)
C	PF13927	e4depC3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)
C	PF18452	e4depC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF18452	ECOD (1.6)
F	F_UNCLASSIFIED	e4depF3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF13895	e4depF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13895	ECOD (1.6)
F	PF18452	e4depF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF18452	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
D	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B, E	receptor accessory protein) complex	3C-LIKE	Homo sapiens (human)	IL1R1*01	C-LIKE-DOMAIN C-LIKE	RPI	3C-LIKE	IMGT (202416-0)
C, F	receptor accessory protein) complex	3C-LIKE	Homo sapiens (human)	IL1RAP*01	C-LIKE-DOMAIN C-LIKE	RPI	3C-LIKE	IMGT (202416-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF00340	Interleukin-1 / 18 (IL1)	Interleukin-1 / 18	This family includes interleukin-1 and interleukin-18.	Domain
B, E	PF18452	Immunoglobulin domain (Ig_6)	Immunoglobulin domain	This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nin ...	This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond [1].	Domain
B, E	PF13895	Immunoglobulin domain (Ig_2)	Immunoglobulin domain	This domain contains immunoglobulin-like domains.	Domain
C, F	PF18452	Immunoglobulin domain (Ig_6)	Immunoglobulin domain	This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nin ...	This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Interleukin-1 beta	protein binding binding interleukin-1 receptor binding signaling receptor binding cytokine receptor binding growth factor receptor binding protein domain specific binding cell adhesion molecule binding protein-containing complex binding integrin binding molecular function activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity protein binding binding interleukin-1 receptor binding signaling receptor binding cytokine receptor binding growth factor receptor binding protein domain specific binding cell adhesion molecule binding protein-containing complex binding integrin binding molecular function activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process developmental process multicellular organismal process regulation of multicellular organismal development regulation of cellular process regulation of developmental process cellular developmental process cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development neurogenesis cell differentiation anatomical structure development regulation of multicellular organismal process cellular process system development cellular response to stimulus response to stimulus regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity regulation of MAP kinase activity intracellular signal transduction negative regulation of cellular metabolic process regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process intracellular signaling cassette negative regulation of protein modification process signal transduction phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of MAPK cascade regulation of molecular function regulation of kinase activity regulation of response to stimulus negative regulation of protein phosphorylation regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process macromolecule metabolic process regulation of protein modification process regulation of protein phosphorylation signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphate metabolic process negative regulation of cell communication organic substance metabolic process regulation of intracellular signal transduction negative regulation of protein serine/threonine kinase activity negative regulation of cellular process protein metabolic process negative regulation of macromolecule metabolic process regulation of signaling organonitrogen compound metabolic process negative regulation of response to stimulus negative regulation of molecular function negative regulation of MAP kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of protein kinase activity negative regulation of signal transduction negative regulation of phosphorus metabolic process MAPK cascade regulation of cell communication regulation of phosphorylation negative regulation of phosphorylation negative regulation of MAPK cascade cell chemotaxis chemotaxis neutrophil chemotaxis response to external stimulus neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis immune system process granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion positive regulation of DNA-binding transcription factor activity cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription apoptotic process cell death programmed cell death regulation of localization hexose transmembrane transport transport carbohydrate transport negative regulation of transport negative regulation of transmembrane transport localization glucose transmembrane transport regulation of transport organic substance transport establishment of localization transmembrane transport regulation of glucose transmembrane transport negative regulation of glucose transmembrane transport regulation of transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport protein localization negative regulation of protein transport establishment of protein localization system process nitrogen compound transport negative regulation of adiponectin secretion regulation of adiponectin secretion adiponectin secretion negative regulation of secretion cellular macromolecule localization negative regulation of hormone secretion negative regulation of secretion by cell regulation of biological quality regulation of hormone levels establishment of protein localization to extracellular region negative regulation of establishment of protein localization protein secretion regulation of protein secretion regulation of secretion endocrine hormone secretion negative regulation of protein secretion negative regulation of multicellular organismal process cellular localization regulation of hormone secretion regulation of protein localization hormone secretion protein localization to extracellular region secretion by cell regulation of secretion by cell signal release negative regulation of protein localization secretion regulation of establishment of protein localization export from cell cell-cell signaling regulation of protein transport endocrine process protein transport regulation of cellular localization macromolecule localization hormone transport regulation of cellular component organization negative regulation of cellular component organization gap junction assembly regulation of gap junction assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of cell junction assembly negative regulation of gap junction assembly cell junction organization cellular component assembly negative regulation of cell junction assembly cell junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization positive regulation of organelle organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle regulation of mitotic cell cycle positive regulation of cell cycle process cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division positive regulation of interleukin-8 production positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process interleukin-8 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production positive regulation of cellular biosynthetic process regulation of interleukin-8 production astrocyte differentiation astrocyte activation glial cell development astrocyte development gliogenesis response to stress defense response cell activation central nervous system development glial cell differentiation glial cell activation inflammatory response neuroinflammatory response JNK cascade reproductive process developmental process involved in reproduction programmed cell death involved in cell development ectopic germ cell programmed cell death positive regulation of cell adhesion regulation of cell adhesion positive regulation of cell-cell adhesion heterotypic cell-cell adhesion cell adhesion cell-cell adhesion positive regulation of heterotypic cell-cell adhesion regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion cellular response to xenobiotic stimulus response to xenobiotic stimulus negative regulation of neurogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process negative regulation of cell development positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation positive regulation of lymphocyte activation positive regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction positive regulation of response to stimulus positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of signaling negative regulation of extrinsic apoptotic signaling pathway in absence of ligand signal transduction in absence of ligand regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand cell surface receptor signaling pathway negative regulation of programmed cell death regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of apoptotic signaling pathway immune response regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development positive regulation of developmental process positive regulation of cell differentiation animal organ development tissue development epithelial to mesenchymal transition mesenchymal cell differentiation fever generation acute-phase response homeostatic process heat generation multicellular organismal-level homeostasis temperature homeostasis acute inflammatory response positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity regulation of monooxygenase activity positive regulation of monooxygenase activity positive regulation of calcidiol 1-monooxygenase activity regulation of calcidiol 1-monooxygenase activity carbohydrate derivative biosynthetic process mucopolysaccharide metabolic process glycosaminoglycan metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process hyaluronan biosynthetic process hyaluronan metabolic process aminoglycan metabolic process aminoglycan biosynthetic process glycosaminoglycan biosynthetic process multi-multicellular organism process female pregnancy embryo implantation multi-organism reproductive process positive regulation of cell adhesion molecule production regulation of cell adhesion molecule production cell adhesion molecule production positive regulation of phosphorylation positive regulation of phosphate metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of protein phosphorylation positive regulation of MAP kinase activity positive regulation of phosphorus metabolic process positive regulation of MAPK cascade positive regulation of kinase activity positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process positive regulation of myosin light chain kinase activity regulation of myosin light chain kinase activity response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction p38MAPK cascade positive regulation of p38MAPK cascade regulation of p38MAPK cascade muscle adaptation smooth muscle adaptation muscle system process response to organic substance response to cytokine cytokine-mediated signaling pathway cellular response to interleukin-1 interleukin-1-mediated signaling pathway cellular response to cytokine stimulus cellular response to organic substance response to interleukin-1 regulation of prostaglandin secretion monocarboxylic acid transport fatty acid transport prostaglandin secretion positive regulation of icosanoid secretion carboxylic acid transport lipid transport regulation of fatty acid transport organic acid transport positive regulation of lipid transport lipid export from cell prostaglandin transport regulation of lipid transport positive regulation of secretion by cell positive regulation of secretion icosanoid transport regulation of icosanoid secretion positive regulation of prostaglandin secretion icosanoid secretion organic anion transport lipid localization positive regulation of lipid localization positive regulation of organic acid transport positive regulation of transport regulation of lipid localization regulation of organic acid transport positive regulation of fatty acid transport positive regulation of nervous system development regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of glial cell proliferation positive regulation of neurogenesis positive regulation of cell development glial cell proliferation regulation of nitric-oxide synthase activity biological process involved in interspecies interaction between organisms response to lipid response to other organism response to oxygen-containing compound response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin regulation of type II interferon production type II interferon production positive regulation of type II interferon production response to carbohydrate regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus defense response to symbiont regulation of defense response to virus defense response to virus defense response to other organism regulation of response to stress regulation of defense response to virus by host response to virus adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity T cell cytokine production positive regulation of immune response T-helper 1 cell cytokine production leukocyte mediated immunity positive regulation of adaptive immune response positive regulation of T cell cytokine production regulation of T cell mediated immunity regulation of cytokine production involved in immune response regulation of adaptive immune response T-helper 1 type immune response regulation of T-helper 1 type immune response immune effector process regulation of leukocyte mediated immunity positive regulation of production of molecular mediator of immune response regulation of immune response regulation of production of molecular mediator of immune response positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of T-helper 1 cell cytokine production regulation of T-helper 1 cell cytokine production regulation of T cell cytokine production CD4-positive, alpha-beta T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune effector process cytokine production involved in immune response production of molecular mediator of immune response positive regulation of T-helper 1 type immune response adaptive immune response regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response cellular response to interleukin-17 response to interleukin-17 regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response positive regulation of defense response cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway regulation of vascular endothelial growth factor receptor signaling pathway cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus vascular endothelial growth factor receptor signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway response to growth factor regulation of humoral immune response humoral immune response complement activation positive regulation of humoral immune response positive regulation of complement activation regulation of complement activation activation of immune response positive regulation of cell division cell division regulation of cell division monocyte aggregation leukocyte aggregation cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway regulation of cellular response to insulin stimulus response to hormone cellular response to hormone stimulus response to organonitrogen compound regulation of insulin receptor signaling pathway cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound negative regulation of cellular response to insulin stimulus cellular response to organonitrogen compound negative regulation of insulin receptor signaling pathway response to insulin cellular response to insulin stimulus prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process regulation of lipid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process cellular ketone metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process positive regulation of prostaglandin biosynthetic process small molecule metabolic process prostaglandin biosynthetic process regulation of cellular ketone metabolic process cellular lipid metabolic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process monocarboxylic acid metabolic process positive regulation of unsaturated fatty acid biosynthetic process regulation of prostaglandin biosynthetic process icosanoid metabolic process regulation of unsaturated fatty acid biosynthetic process lipid biosynthetic process positive regulation of fatty acid biosynthetic process prostanoid metabolic process icosanoid biosynthetic process prostanoid biosynthetic process positive regulation of fatty acid metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process positive regulation of lipid biosynthetic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process lipid metabolic process positive regulation of JNK cascade regulation of JNK cascade regulation of peptide hormone secretion regulation of peptide secretion peptide secretion amide transport regulation of peptide transport peptide transport regulation of insulin secretion peptide hormone secretion insulin secretion positive regulation of NF-kappaB transcription factor activity negative regulation of lipid metabolic process ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade trans-synaptic signaling modulation of chemical synaptic transmission negative regulation of synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling negative regulation of catabolic process lipid catabolic process catabolic process regulation of catabolic process regulation of lipid catabolic process organic substance catabolic process negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis macromolecule catabolic process cellular catabolic process regulation of proteolysis proteolysis membrane protein proteolysis membrane protein ectodomain proteolysis organonitrogen compound catabolic process regulation of membrane protein ectodomain proteolysis protein catabolic process positive regulation of protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of cellular catabolic process positive regulation of cellular catabolic process regulation of protein catabolic process mononuclear cell differentiation lymphocyte differentiation T cell differentiation in thymus regulation of immature T cell proliferation T cell differentiation positive regulation of immature T cell proliferation regulation of immature T cell proliferation in thymus leukocyte differentiation immature T cell proliferation in thymus positive regulation of immature T cell proliferation in thymus hemopoiesis immature T cell proliferation transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production cellular response to lipopolysaccharide cellular response to molecule of bacterial origin cellular response to biotic stimulus cellular response to lipid positive regulation of lipid catabolic process regulation of monocyte chemotactic protein-1 production positive regulation of monocyte chemotactic protein-1 production monocyte chemotactic protein-1 production regulation of chemokine production chemokine production positive regulation of chemokine production nucleocytoplasmic transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization positive regulation of protein transport establishment of localization in cell positive regulation of intracellular transport nuclear export regulation of protein export from nucleus regulation of intracellular transport intracellular transport regulation of nucleocytoplasmic transport protein export from nucleus positive regulation of protein export from nucleus positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport negative regulation of cell population proliferation angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis regulation of interleukin-2 production interleukin-2 production positive regulation of interleukin-2 production response to organophosphorus response to ATP response to purine-containing compound response to organic cyclic compound granulocyte macrophage colony-stimulating factor production positive regulation of granulocyte macrophage colony-stimulating factor production regulation of granulocyte macrophage colony-stimulating factor production regulation of establishment of endothelial barrier endothelium development epithelial cell differentiation regulation of epithelial cell differentiation endothelial cell development regulation of endothelial cell development epithelium development endothelial cell differentiation regulation of endothelial cell differentiation epithelial cell development establishment of endothelial barrier sequestering of triglyceride lipid storage maintenance of location positive regulation of neuroinflammatory response regulation of neuroinflammatory response regulation of heat generation positive regulation of heat generation positive regulation of acute inflammatory response positive regulation of fever generation regulation of acute inflammatory response regulation of fever generation defense response to Gram-positive bacterium defense response to bacterium	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol extracellular region extracellular space membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome intracellular vesicle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol extracellular region extracellular space membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome intracellular vesicle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle vesicle
B, E	Interleukin-1 receptor type 1	hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein binding binding signaling receptor binding platelet-derived growth factor receptor binding growth factor receptor binding enzyme binding protease binding interleukin-1 binding growth factor binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein binding binding signaling receptor binding platelet-derived growth factor receptor binding growth factor receptor binding enzyme binding protease binding interleukin-1 binding growth factor binding cytokine binding interleukin-1, type I, activating receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity interleukin-1 receptor activity NADP+ nucleosidase activity	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response T-helper 1 cell cytokine production cytokine production organic substance biosynthetic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response T-helper 1 cell cytokine production cytokine production organic substance biosynthetic process leukocyte mediated immunity regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of adaptive immune response positive regulation of T cell cytokine production positive regulation of immune system process regulation of T cell mediated immunity regulation of biological process regulation of cytokine production involved in immune response immune response regulation of adaptive immune response cellular metabolic process regulation of cellular metabolic process T-helper 1 type immune response regulation of T-helper 1 type immune response immune effector process regulation of gene expression regulation of leukocyte mediated immunity biosynthetic process regulation of response to stimulus positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of immune response metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity cellular biosynthetic process positive regulation of T-helper 1 cell cytokine production positive regulation of biological process positive regulation of cellular metabolic process regulation of T-helper 1 cell cytokine production positive regulation of response to stimulus regulation of T cell cytokine production CD4-positive, alpha-beta T cell cytokine production organic substance metabolic process regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of biosynthetic process regulation of cytokine production positive regulation of immune effector process regulation of multicellular organismal process cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process positive regulation of T-helper 1 type immune response biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process adaptive immune response regulation of cellular biosynthetic process regulation of lymphocyte mediated immunity positive regulation of gene expression immune system process positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response cellular process positive regulation of cellular biosynthetic process positive regulation of locomotion regulation of cell motility regulation of neutrophil extravasation positive regulation of cell migration positive regulation of cell motility myeloid leukocyte migration cellular extravasation regulation of cell migration cell migration cell motility locomotion neutrophil extravasation regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of neutrophil migration neutrophil migration granulocyte migration leukocyte migration positive regulation of neutrophil extravasation regulation of locomotion regulation of neutrophil migration positive regulation of cellular extravasation regulation of cellular extravasation response to organic substance response to chemical response to cytokine response to interleukin-1 cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cell communication cellular response to cytokine stimulus cellular response to organic substance signal transduction regulation of interleukin-1-mediated signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway cellular response to interleukin-1 regulation of response to cytokine stimulus cellular response to chemical stimulus interleukin-1-mediated signaling pathway positive regulation of interleukin-1-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus response to stress regulation of response to stress inflammatory response regulation of type II interferon production type II interferon production positive regulation of type II interferon production	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular region
C, F	Interleukin-1 receptor accessory protein	molecular transducer activity coreceptor activity signaling receptor activity hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity transmembrane signaling receptor activity cytokine receptor activity immune receptor activity interleukin-1 receptor activity protein binding binding molecular transducer activity coreceptor activity signaling receptor activity hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity transmembrane signaling receptor activity cytokine receptor activity immune receptor activity interleukin-1 receptor activity protein binding binding interleukin-1 receptor binding signaling receptor binding cytokine receptor binding growth factor receptor binding NADP+ nucleosidase activity interleukin-33 receptor activity	multicellular organismal process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of interleukin-5 production organic substance metabolic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process multicellular organismal process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of interleukin-5 production organic substance metabolic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process interleukin-5 production positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process positive regulation of interleukin-5 production positive regulation of cellular biosynthetic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis positive regulation of nervous system development positive regulation of cellular component organization regulation of cellular component organization regulation of developmental process regulation of nervous system development positive regulation of developmental process multicellular organism development cell junction assembly anatomical structure development regulation of synapse structure or activity synapse organization regulation of synapse assembly regulation of biological quality system development developmental process regulation of multicellular organismal development positive regulation of cellular component biogenesis nervous system development regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly positive regulation of synapse assembly response to stimulus immune response immune system process interleukin-13 production positive regulation of interleukin-13 production regulation of interleukin-13 production interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production cell adhesion cell-cell adhesion synaptic membrane adhesion cell-cell adhesion via plasma-membrane adhesion molecules cellular response to stimulus response to organic substance cell surface receptor signaling pathway signaling interleukin-33-mediated signaling pathway response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance signal transduction regulation of presynapse assembly regulation of presynapse organization presynapse organization presynapse assembly biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus trans-synaptic signaling synaptic signaling trans-synaptic signaling by trans-synaptic complex cell-cell signaling regulation of postsynaptic specialization assembly regulation of excitatory synapse assembly postsynaptic density organization regulation of postsynaptic density organization postsynapse organization organelle assembly postsynaptic specialization assembly postsynapse assembly regulation of postsynapse organization regulation of organelle organization excitatory synapse assembly organelle organization regulation of organelle assembly postsynaptic specialization organization postsynaptic density assembly regulation of postsynaptic density assembly cellular response to interleukin-1 interleukin-1-mediated signaling pathway response to interleukin-1 inflammatory response regulation of interleukin-4 production positive regulation of interleukin-4 production interleukin-4 production	membrane cellular anatomical entity cell periphery plasma membrane synapse cell junction glutamatergic synapse extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR020877	Interleukin-1 conserved site	Conserved Site
A, D	IPR008996	Cytokine IL1/FGF	Homologous Superfamily
A, D	IPR000975	Interleukin-1 family	Family
A, D	IPR003502	Interleukin-1 propeptide	Domain
B, E	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
B, E	IPR004074	Interleukin-1 receptor type I/II	Family
B, E	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, E	IPR003599	Immunoglobulin subtype	Domain
B, E	IPR041416	IL-1Ra-like, immunoglobulin domain	Domain
B, E	IPR004076	Interleukin-1 receptor type 1	Family
B, E	IPR015621	Interleukin-1 receptor family	Family
B, E	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, E	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
B, E	IPR007110	Immunoglobulin-like domain	Domain
C, F	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
C, F	IPR004074	Interleukin-1 receptor type I/II	Family
C, F	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C, F	IPR003599	Immunoglobulin subtype	Domain
C, F	IPR041416	IL-1Ra-like, immunoglobulin domain	Domain
C, F	IPR015621	Interleukin-1 receptor family	Family
C, F	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C, F	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
C, F	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D	Pharos: P01584	psoriasis glioblastoma ulcerative colitis neutropenia cancer gout colitis polymyositis Kearns-Sayre syndrome Leber hereditary optic neuropathy bronchopulmonary dysplasia MELAS syndrome anthracosis gastric ulcer cardiomyopathy psoriasis glioblastoma ulcerative colitis neutropenia cancer gout colitis polymyositis Kearns-Sayre syndrome Leber hereditary optic neuropathy bronchopulmonary dysplasia MELAS syndrome anthracosis gastric ulcer cardiomyopathy asthma silicosis pneumonia Alzheimer disease dermatomyositis rheumatoid arthritis hypertensive disorder MERRF syndrome peptic ulcer disease glomerulonephritis hemolytic-uremic syndrome myopathy allergic disease pulmonary fibrosis HIV wasting syndrome Fibrosis visceral leishmaniasis hypoglycemia giant cell glioblastoma middle cerebral artery infarction pleurisy malignant colon neoplasm skin disease bipolar disorder heart valve disease congestive heart failure postmenopausal osteoporosis coronary artery disease breast cancer tuberculosis hereditary diffuse gastric adenocarcinoma cutaneous leishmaniasis gastric cancer leukopenia schizophrenia visual epilepsy cerebrovascular disorder granular cell carcinoma lymphopenia adenocarcinoma thyroid gland carcinoma extrahepatic cholestasis brain ischemia trigeminal neuralgia breast carcinoma manganese poisoning tubular adenocarcinoma calcinosis urticaria inborn mitochondrial myopathy chronic atrophic gastritis thyroid adenoma multiple sclerosis myocardial infarction progressive external ophthalmoplegia cystic fibrosis pyogenic arthritis-pyoderma gangrenosum-acne syndrome dermatitis, atopic non-small cell lung carcinoma gastric neoplasm vasculitis hyperglycemia liver disease gastrointestinal mucositis diarrheal disease arthritic joint disease mevalonic aciduria idiopathic interstitial pneumonia infectious meningitis periodontitis lung cancer synovitis acne influenza pilocytic astrocytoma lymphatic system disease thrombotic disease chronic obstructive pulmonary disease Barrett esophagus thyroid cancer heart disease ischemia reperfusion injury malignant mesothelioma brain injury toxic encephalopathy myocardial ischemia allergic rhinitis learning disability cribriform carcinoma of breast alopecia areata type 2 diabetes mellitus dementia non-alcoholic fatty liver disease osteoarthritis pancreatitis lung adenocarcinoma inborn carbohydrate metabolic disorder peripheral neuropathy lung carcinoma inherited disease susceptibility atopic eczema head and neck cancer mood disorder adenoma interstitial cystitis benign colon neoplasm malignant ependymoma heart failure colonic neoplasm muscle tissue disease sleep-wake disorder kidney disease malignant pancreatic neoplasm COVID-19 familial Mediterranean fever pulmonary edema HIV infectious disease Crohn disease neurodegenerative disease pustulosis palmaris et plantaris burn cutaneous lupus erythematosus depressive disorder gastric carcinoma obesity disorder osteoarthritis susceptibility 1 hypotensive disorder lung benign neoplasm drug-induced liver injury peritonitis atherosclerosis inherited lipid metabolism disorder endometriosis autoimmune disease major depressive disorder adult acute respiratory distress syndrome interstitial lung disease epilepsy pneumonitis benign neoplasm malignant glioma muscular disease juvenile dermatomyositis exocrine pancreatic carcinoma eye disease hepatocellular carcinoma cribriform carcinoma
B, E	Pharos: P14778	endometriosis allergic disease ulcerative colitis pneumonia dermatomyositis psoriasis subependymal giant cell astrocytoma Gaucher disease interstitial cystitis adenoma Lobar Pneumonia malignant ependymoma asthma MALT lymphoma oligodendroglioma endometriosis allergic disease ulcerative colitis pneumonia dermatomyositis psoriasis subependymal giant cell astrocytoma Gaucher disease interstitial cystitis adenoma Lobar Pneumonia malignant ependymoma asthma MALT lymphoma oligodendroglioma breast cancer pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma cystic fibrosis pneumonitis rheumatoid arthritis Duchenne muscular dystrophy tuberculosis juvenile dermatomyositis adrenal cortex carcinoma lung cancer ankylosing spondylitis malignant mesothelioma autoimmune disease medulloblastoma brain injury ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Crohn disease pituitary cancer primary biliary cholangitis skin disease large cell medulloblastoma lung carcinoma arthritic joint disease malignant pancreatic neoplasm myopathy pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
C, F	Pharos: Q9NPH3	liver disease Squamous Cell Carcinoma of Head and Neck hepatocellular carcinoma lung cancer malignant pancreatic neoplasm pancreatic ductal adenocarcinoma rheumatoid arthritis tuberculosis glioblastoma lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm spina bifida head and neck squamous cell carcinoma malignant glioma liver disease Squamous Cell Carcinoma of Head and Neck hepatocellular carcinoma lung cancer malignant pancreatic neoplasm pancreatic ductal adenocarcinoma rheumatoid arthritis tuberculosis glioblastoma lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm spina bifida head and neck squamous cell carcinoma malignant glioma ovarian cancer pilocytic astrocytoma