4DD8

ADAM-8 metalloproteinase domain with bound batimastat

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4dd8a_	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4dd8b_	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4dd8c_	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4dd8d_	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Reprolysin	e4dd8A1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Reprolysin	ECOD (1.6)
B	Reprolysin	e4dd8B1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Reprolysin	ECOD (1.6)
C	Reprolysin	e4dd8C1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Reprolysin	ECOD (1.6)
D	Reprolysin	e4dd8D1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Reprolysin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
B	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
C	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
D	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01421	Reprolysin (M12B) family zinc metalloprotease (Reprolysin)	Reprolysin (M12B) family zinc metalloprotease	The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammal ...	The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin Swiss:Q28472. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Disintegrin and metalloproteinase domain-containing protein 8	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity cation binding ion binding binding calcium ion binding metal ion binding peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding metalloendopeptidase activity cell adhesion molecule binding protein binding transition metal ion binding zinc ion binding	positive regulation of locomotion regulation of cell motility regulation of cellular process positive regulation of biological process positive regulation of cell migration eosinophil migration positive regulation of cell motility regulation of cell migration myeloid leukocyte migration cell migration regulation of immune system process cell motility positive regulation of immune system process locomotion positive regulation of locomotion regulation of cell motility regulation of cellular process positive regulation of biological process positive regulation of cell migration eosinophil migration positive regulation of cell motility regulation of cell migration myeloid leukocyte migration cell migration regulation of immune system process cell motility positive regulation of immune system process locomotion positive regulation of cellular process regulation of biological process positive regulation of eosinophil migration regulation of leukocyte migration biological regulation positive regulation of leukocyte migration granulocyte migration regulation of eosinophil migration leukocyte migration immune system process regulation of locomotion cellular process regulation of neutrophil extravasation cellular extravasation neutrophil extravasation positive regulation of neutrophil migration neutrophil migration positive regulation of neutrophil extravasation regulation of neutrophil migration positive regulation of cellular extravasation regulation of cellular extravasation response to decreased oxygen levels cellular response to stimulus response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical response to oxygen levels response to abiotic stimulus regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of acute inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress positive regulation of defense response regulation of acute inflammatory response inflammatory response acute inflammatory response positive regulation of thymocyte migration extracellular matrix-dependent thymocyte migration regulation of lymphocyte migration thymocyte migration regulation of thymocyte migration positive regulation of mononuclear cell migration regulation of mononuclear cell migration regulation of fibronectin-dependent thymocyte migration positive regulation of fibronectin-dependent thymocyte migration positive regulation of lymphocyte migration positive regulation of T cell migration lymphocyte migration substrate-dependent cell migration mononuclear cell migration regulation of T cell migration fibronectin-dependent thymocyte migration T cell migration cell adhesion cell-cell adhesion regulation of cell adhesion regulation of cell-cell adhesion leukocyte migration involved in inflammatory response developmental process anatomical structure morphogenesis anatomical structure development cell morphogenesis multicellular organismal process homeostatic process regulation of bone remodeling tissue homeostasis regulation of tissue remodeling regulation of bone resorption bone resorption multicellular organismal-level homeostasis tissue remodeling bone remodeling anatomical structure homeostasis positive regulation of multicellular organismal process regulation of multicellular organismal process positive regulation of bone resorption cell chemotaxis chemotaxis lymphocyte chemotaxis taxis leukocyte chemotaxis catabolic process positive regulation of protein metabolic process positive regulation of membrane protein ectodomain proteolysis positive regulation of cellular metabolic process macromolecule catabolic process regulation of primary metabolic process cellular catabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis proteolysis membrane protein proteolysis positive regulation of macromolecule metabolic process protein metabolic process membrane protein ectodomain proteolysis organonitrogen compound catabolic process regulation of membrane protein ectodomain proteolysis organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of catabolic process regulation of macromolecule metabolic process protein catabolic process positive regulation of protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of cellular catabolic process positive regulation of cellular catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process cellular biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of biosynthetic process tumor necrosis factor (ligand) superfamily member 11 production cytokine production organic substance biosynthetic process regulation of cytokine production regulation of biosynthetic process positive regulation of tumor necrosis factor (ligand) superfamily member 11 production tumor necrosis factor superfamily cytokine production gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression regulation of tumor necrosis factor (ligand) superfamily member 11 production biosynthetic process regulation of tumor necrosis factor superfamily cytokine production positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of cytokine production positive regulation of cellular biosynthetic process signaling canonical NF-kappaB signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development system development regulation of epithelial to mesenchymal transition regulation of developmental process cellular developmental process positive regulation of epithelial to mesenchymal transition regulation of cell differentiation mesenchyme development positive regulation of developmental process positive regulation of cell differentiation cell differentiation animal organ development tissue development epithelial to mesenchymal transition mesenchymal cell differentiation regulation of protein maturation positive regulation of protein maturation positive regulation of protein processing protein maturation regulation of protein processing protein processing regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development T cell differentiation in thymus positive regulation of cell activation positive regulation of T cell differentiation in thymus T cell activation positive regulation of leukocyte activation T cell differentiation positive regulation of T cell activation positive regulation of cell development regulation of leukocyte cell-cell adhesion leukocyte differentiation cell development positive regulation of leukocyte cell-cell adhesion regulation of T cell differentiation in thymus lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation positive regulation of hemopoiesis regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis positive regulation of cell adhesion cell activation regulation of T cell activation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction regulation of signal transduction regulation of intracellular signal transduction regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling cellular component organization cellular component disassembly extracellular matrix disassembly extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of neuron apoptotic process leukocyte apoptotic process positive regulation of thymocyte apoptotic process lymphocyte apoptotic process thymocyte apoptotic process regulation of T cell apoptotic process positive regulation of leukocyte apoptotic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process positive regulation of programmed cell death positive regulation of lymphocyte apoptotic process positive regulation of apoptotic process positive regulation of T cell apoptotic process regulation of thymocyte apoptotic process T cell apoptotic process positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of transport secretion organic substance transport regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to biotic stimulus positive regulation of immune response innate immune response response to external biotic stimulus positive regulation of innate immune response immune response response to other organism regulation of innate immune response defense response to symbiont defense response to other organism regulation of immune response	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule dense core granule dense core granule membrane podosome cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle phagolysosome lytic vacuole vacuole phagocytic vesicle secondary lysosome endocytic vesicle lysosome tertiary granule membrane tertiary granule cell surface cell periphery plasma membrane protein-containing complex plasma membrane protein complex alpha9-beta1 integrin-ADAM8 complex membrane protein complex ficolin-1-rich granule membrane ficolin-1-rich granule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR018358	Disintegrin, conserved site	Conserved Site
A, B, C, D	IPR001590	Peptidase M12B, ADAM/reprolysin	Domain
A, B, C, D	IPR001762	Disintegrin domain	Domain
A, B, C, D	IPR036436	Disintegrin domain superfamily	Homologous Superfamily
A, B, C, D	IPR000742	EGF-like domain	Domain
A, B, C, D	IPR034027	Reprolysin domain, adamalysin-type	Domain
A, B, C, D	IPR024079	Metallopeptidase, catalytic domain superfamily	Homologous Superfamily
A, B, C, D	IPR002870	Peptidase M12B, propeptide	Domain
A, B, C, D	IPR006586	ADAM, cysteine-rich domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P78325	pancreatic intraductal papillary-mucinous neoplasm atopic eczema Chemically-Induced Liver Toxicity lung adenocarcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer cutaneous lupus erythematosus drug-induced liver injury malignant colon neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma ductal breast carcinoma in situ invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous neoplasm atopic eczema Chemically-Induced Liver Toxicity lung adenocarcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer cutaneous lupus erythematosus drug-induced liver injury malignant colon neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma ductal breast carcinoma in situ invasive ductal breast carcinoma malignant mesothelioma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.