4D6U

Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038258	3001831	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038259	3001831	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038260	3001831	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038263	3001831	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Transmembrane di-heme cytochromes	8038265	3000517	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038264	3000966	SCOP2B (2022-06-29)
M [auth P]	SCOP2B Superfamily	Transmembrane di-heme cytochromes	8038265	3000517	SCOP2B (2022-06-29)
M [auth P]	SCOP2B Superfamily	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038264	3000966	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) transmembrane anchor	8038268	3000762	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cytochrome c	8038266	3000815	SCOP2B (2022-06-29)
N [auth Q]	SCOP2B Superfamily	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) transmembrane anchor	8038268	3000762	SCOP2B (2022-06-29)
N [auth Q]	SCOP2B Superfamily	Cytochrome c	8038266	3000815	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ISP transmembrane anchor	8038269	3000753	SCOP2B (2022-06-29)
O [auth R]	SCOP2B Superfamily	ISP domain	8038267	3000233	SCOP2B (2022-06-29)
O [auth R]	SCOP2B Superfamily	ISP transmembrane anchor	8038269	3000753	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038272	3000797	SCOP2B (2022-06-29)
P [auth S]	SCOP2B Superfamily	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038272	3000797	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038275	3000806	SCOP2B (2022-06-29)
R [auth U]	SCOP2B Superfamily	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038275	3000806	SCOP2B (2022-06-29)
K [auth N]	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038259	3001831	SCOP2B (2022-06-29)
K [auth N]	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038258	3001831	SCOP2B (2022-06-29)
L [auth O]	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038263	3001831	SCOP2B (2022-06-29)
L [auth O]	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038260	3001831	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038274	3000770	SCOP2B (2022-06-29)
Q [auth T]	SCOP2B Superfamily	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038274	3000770	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8037844	3000779	SCOP2B (2022-06-29)
T [auth W]	SCOP2B Superfamily	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8037844	3000779	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00675,PF05193	e4d6uA2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: PF00675,PF05193	ECOD (1.6)
A	PF05193	e4d6uA1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: PF05193	ECOD (1.6)
B	PF00675	e4d6uB2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: PF00675	ECOD (1.6)
B	PF05193	e4d6uB1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: PF05193	ECOD (1.6)
C	PF00032	e4d6uC1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF00032	ECOD (1.6)
C	PF00033	e4d6uC2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: PF00033	ECOD (1.6)
M [auth P]	PF00032	e4d6uP1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF00032	ECOD (1.6)
M [auth P]	PF00033	e4d6uP2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: PF00033	ECOD (1.6)
D	PF02167	e4d6uD2	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: PF02167	ECOD (1.6)
D	F_UNCLASSIFIED	e4d6uD1	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: F_UNCLASSIFIED	ECOD (1.6)
N [auth Q]	PF02167	e4d6uQ2	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: PF02167	ECOD (1.6)
N [auth Q]	F_UNCLASSIFIED	e4d6uQ1	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF02921	e4d6uE1	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: PF02921	ECOD (1.6)
I	PF09165	e4d6uI1	A: extended segments	X: Ubiquinol-cytochrome c reductase 8 kDa protein (From Topology)	H: Ubiquinol-cytochrome c reductase 8 kDa protein (From Topology)	T: Ubiquinol-cytochrome c reductase 8 kDa protein	F: PF09165	ECOD (1.6)
O [auth R]	PF00355	e4d6uR3	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: PF00355	ECOD (1.6)
O [auth R]	PF02921	e4d6uR2	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: PF02921	ECOD (1.6)
F	PF02271	e4d6uF1	A: alpha arrays	X: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF02271	ECOD (1.6)
P [auth S]	PF02271	e4d6uS1	A: alpha arrays	X: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF02271	ECOD (1.6)
H	PF02320	e4d6uH1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF02320	ECOD (1.6)
R [auth U]	PF02320	e4d6uU1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF02320	ECOD (1.6)
K [auth N]	PF00675,PF05193	e4d6uN1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: PF00675,PF05193	ECOD (1.6)
K [auth N]	PF05193	e4d6uN2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: PF05193	ECOD (1.6)
L [auth O]	PF00675	e4d6uO1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: PF00675	ECOD (1.6)
L [auth O]	PF05193	e4d6uO2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: PF05193	ECOD (1.6)
G	PF02939	e4d6uG1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF02939	ECOD (1.6)
Q [auth T]	PF02939	e4d6uT1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF02939	ECOD (1.6)
J	PF05365	e4d6uJ1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF05365	ECOD (1.6)
T [auth W]	PF05365	e4d6uW1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF05365	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
A	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
B	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
B	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
C, M [auth P]	PF00032	Cytochrome b(C-terminal)/b6/petD (Cytochrom_B_C)	Cytochrome b(C-terminal)/b6/petD	-	Domain
C, M [auth P]	PF00033	Cytochrome b/b6/petB (Cytochrome_B)	Cytochrome b/b6/petB	-	Domain
D, N [auth Q]	PF02167	Cytochrome C1 family (Cytochrom_C1)	Cytochrome C1 family	-	Family
E, I, O [auth R]	PF02921	Ubiquinol cytochrome reductase transmembrane region (UCR_TM)	Ubiquinol cytochrome reductase transmembrane region	-	Family
E, I, O [auth R]	PF09165	Ubiquinol-cytochrome c reductase 8 kDa, N-terminal (Ubiq-Cytc-red_N)	Ubiquinol-cytochrome c reductase 8 kDa, N-terminal	Members of this family adopt a structure consisting of many antiparallel beta sheets, with few alpha helices, in a non-globular arrangement. They are required for proper functioning of the respiratory chain [1].	Domain
E, I, O [auth R]	PF00355	Rieske [2Fe-2S] domain (Rieske)	Rieske [2Fe-2S] domain	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in ...	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].	Domain
F, P [auth S]	PF02271	Ubiquinol-cytochrome C reductase complex 14kD subunit (UCR_14kD)	Ubiquinol-cytochrome C reductase complex 14kD subunit	-	Family
H, R [auth U]	PF02320	Ubiquinol-cytochrome C reductase hinge protein (UCR_hinge)	Ubiquinol-cytochrome C reductase hinge protein	-	Family
K [auth N]	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
K [auth N]	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
L [auth O]	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
L [auth O]	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
S [auth V]	PF09165	Ubiquinol-cytochrome c reductase 8 kDa, N-terminal (Ubiq-Cytc-red_N)	Ubiquinol-cytochrome c reductase 8 kDa, N-terminal	Members of this family adopt a structure consisting of many antiparallel beta sheets, with few alpha helices, in a non-globular arrangement. They are required for proper functioning of the respiratory chain [1].	Domain
G, Q [auth T]	PF02939	UcrQ family (UcrQ)	UcrQ family	-	Family
J, T [auth W]	PF05365	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like (UCR_UQCRX_QCR9)	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL	cation binding ion binding binding metal ion binding small molecule binding	-	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respirasome
B	CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL	cation binding ion binding binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respirasome
C, M [auth P]	CYTOCHROME B	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity binding organic cyclic compound binding tetrapyrrole binding heme binding quinone binding ubiquinone binding small molecule binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane cellular anatomical entity membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex membrane cellular anatomical entity membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle organelle envelope oxidoreductase complex mitochondrial protein-containing complex catalytic complex intracellular membrane-bounded organelle mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex mitochondrial envelope organelle respirasome cytoplasm organelle membrane
D, N [auth Q]	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III oxidoreductase complex mitochondrial protein-containing complex catalytic complex inner mitochondrial membrane protein complex transmembrane transporter complex respirasome
E, I, O [auth R]	CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL	oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity transmembrane transporter activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport cytochrome complex assembly protein-containing complex organization mitochondrial respiratory chain complex III assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly respiratory chain complex III assembly mitochondrial respiratory chain complex assembly protein-containing complex assembly cellular component organization or biogenesis mitochondrion organization	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III oxidoreductase complex mitochondrial protein-containing complex catalytic complex inner mitochondrial membrane protein complex transmembrane transporter complex respirasome respiratory chain complex IV mitochondrial respiratory chain complex IV
F, P [auth S]	CYTOCHROME B-C1 COMPLEX SUBUNIT 7	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle organelle envelope oxidoreductase complex mitochondrial protein-containing complex catalytic complex membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex mitochondrial envelope organelle respirasome cytoplasm organelle membrane
H, R [auth U]	CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle organelle envelope oxidoreductase complex mitochondrial protein-containing complex catalytic complex membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex mitochondrial envelope organelle respirasome cytoplasm organelle membrane
K [auth N]	CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL	cation binding ion binding binding metal ion binding small molecule binding	-	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respirasome
L [auth O]	CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL	cation binding ion binding binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respirasome
S [auth V]	CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL	oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity transmembrane transporter activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport cytochrome complex assembly protein-containing complex organization mitochondrial respiratory chain complex III assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly respiratory chain complex III assembly mitochondrial respiratory chain complex assembly protein-containing complex assembly cellular component organization or biogenesis mitochondrion organization	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III oxidoreductase complex mitochondrial protein-containing complex catalytic complex inner mitochondrial membrane protein complex transmembrane transporter complex respirasome respiratory chain complex IV mitochondrial respiratory chain complex IV
G, Q [auth T]	CYTOCHROME B-C1 COMPLEX SUBUNIT 8	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle organelle envelope oxidoreductase complex mitochondrial protein-containing complex catalytic complex membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex mitochondrial envelope organelle respirasome cytoplasm organelle membrane
J, T [auth W]	CYTOCHROME B-C1 COMPLEX SUBUNIT 9	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle organelle envelope oxidoreductase complex mitochondrial protein-containing complex catalytic complex membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex mitochondrial envelope organelle respirasome cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007863	Peptidase M16, C-terminal	Domain
A	IPR011765	Peptidase M16, N-terminal	Domain
A	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
B	IPR007863	Peptidase M16, C-terminal	Domain
B	IPR011765	Peptidase M16, N-terminal	Domain
B	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
B	IPR001431	Peptidase M16, zinc-binding site	Binding Site
C, M [auth P]	IPR036150	Cytochrome b/b6, C-terminal domain superfamily	Homologous Superfamily
C, M [auth P]	IPR027387	Cytochrome b/b6-like domain superfamily	Homologous Superfamily
C, M [auth P]	IPR048260	Cytochrome b/b6, C-terminal domain, eukaryotic/bacterial	Domain
C, M [auth P]	IPR016174	Di-haem cytochrome, transmembrane	Homologous Superfamily
C, M [auth P]	IPR005798	Cytochrome b/b6, C-terminal	Domain
C, M [auth P]	IPR048259	Cytochrome b/b6, N-terminal domain, eukaryotic/bacterial	Domain
C, M [auth P]	IPR030689	Cytochrome b	Family
C, M [auth P]	IPR005797	Cytochrome b/b6, N-terminal domain	Domain
D, N [auth Q]	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
D, N [auth Q]	IPR002326	Cytochrome c1	Family
D, N [auth Q]	IPR009056	Cytochrome c-like domain	Domain
D, N [auth Q]	IPR021157	Cytochrome c1, transmembrane anchor, C-terminal	Homologous Superfamily
E, I, O [auth R]	IPR036922	Rieske [2Fe-2S] iron-sulphur domain superfamily	Homologous Superfamily
E, I, O [auth R]	IPR014349	Rieske iron-sulphur protein	Family
E, I, O [auth R]	IPR011070	Globular protein, non-globular alpha/beta subunit	Homologous Superfamily
E, I, O [auth R]	IPR004192	Cytochrome b-c1 complex subunit Rieske, transmembrane domain	Domain
E, I, O [auth R]	IPR015248	Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal	Domain
E, I, O [auth R]	IPR017941	Rieske [2Fe-2S] iron-sulphur domain	Domain
E, I, O [auth R]	IPR005805	Rieske iron-sulphur protein, C-terminal	Domain
E, I, O [auth R]	IPR037008	Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily	Homologous Superfamily
E, I, O [auth R]	IPR006317	Ubiquinol-cytochrome c reductase, iron-sulphur subunit	Domain
F, P [auth S]	IPR003197	Cytochrome b-c1 complex subunit 7	Family
F, P [auth S]	IPR036544	Cytochrome b-c1 complex subunit 7 superfamily	Homologous Superfamily
H, R [auth U]	IPR003422	Cytochrome b-c1 complex, subunit 6	Family
H, R [auth U]	IPR023184	Ubiquinol-cytochrome C reductase hinge domain	Domain
H, R [auth U]	IPR036811	Ubiquinol-cytochrome C reductase hinge domain superfamily	Homologous Superfamily
K [auth N]	IPR007863	Peptidase M16, C-terminal	Domain
K [auth N]	IPR011765	Peptidase M16, N-terminal	Domain
K [auth N]	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
L [auth O]	IPR007863	Peptidase M16, C-terminal	Domain
L [auth O]	IPR011765	Peptidase M16, N-terminal	Domain
L [auth O]	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
L [auth O]	IPR001431	Peptidase M16, zinc-binding site	Binding Site
S [auth V]	IPR036922	Rieske [2Fe-2S] iron-sulphur domain superfamily	Homologous Superfamily
S [auth V]	IPR014349	Rieske iron-sulphur protein	Family
S [auth V]	IPR011070	Globular protein, non-globular alpha/beta subunit	Homologous Superfamily
S [auth V]	IPR004192	Cytochrome b-c1 complex subunit Rieske, transmembrane domain	Domain
S [auth V]	IPR015248	Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal	Domain
S [auth V]	IPR017941	Rieske [2Fe-2S] iron-sulphur domain	Domain
S [auth V]	IPR005805	Rieske iron-sulphur protein, C-terminal	Domain
S [auth V]	IPR037008	Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily	Homologous Superfamily
S [auth V]	IPR006317	Ubiquinol-cytochrome c reductase, iron-sulphur subunit	Domain
G, Q [auth T]	IPR004205	Cytochrome b-c1 complex subunit 8	Family
G, Q [auth T]	IPR036642	Cytochrome b-c1 complex subunit 8 superfamily	Homologous Superfamily
J, T [auth W]	IPR008027	Cytochrome b-c1 complex subunit 9	Family
J, T [auth W]	IPR036656	Cytochrome b-c1 complex subunit 9 superfamily	Homologous Superfamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K [auth N], L [auth O], M [auth P], N [auth Q], O [auth R], P [auth S], Q [auth T], R [auth U], S [auth V], T [auth W]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K [auth N], L [auth O], M [auth P], N [auth Q], O [auth R], P [auth S], Q [auth T], R [auth U], S [auth V], T [auth W]	MemProtMD	Annotated as membrane protein by MemProtMD