4D5Y

Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00181	e4d5yA1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF00181	ECOD (1.6)
A	PF03947	e4d5yA2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF03947	ECOD (1.6)
J	PF00281,PF00673	e4d5yJ1	A: a+b two layers	X: Ribosomal protein L5 (From Topology)	H: Ribosomal protein L5 (From Topology)	T: Ribosomal protein L5	F: PF00281,PF00673	ECOD (1.6)
K [auth L]	PF01294	e4d5yL1	A: extended segments	X: RPL13 (From Topology)	H: RPL13 (From Topology)	T: RPL13	F: PF01294	ECOD (1.6)
L [auth M]	PF00467,PF01929	e4d5yM1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF00467,PF01929	ECOD (1.6)
M [auth N]	PF00827	e4d5yN1	A: a+b two layers	X: Alpha-beta plaits	H: Ribosomal proteins S24e, L23 and L15e (From Topology)	T: Ribosomal proteins S24e, L23 and L15e	F: PF00827	ECOD (1.6)
N [auth O]	PF00572	e4d5yO1	A: a/b three-layered sandwiches	X: Ribosomal protein L13/L15p/L18e/L32e	H: Ribosomal protein L13 and L16-A (From Topology)	T: Ribosomal protein L13 and L16-A	F: PF00572	ECOD (1.6)
O [auth P]	PF00237	e4d5yP1	A: a+b two layers	X: Enolase-N/ribosomal protein	H: Ribosomal protein L22 (From Topology)	T: Ribosomal protein L22	F: PF00237	ECOD (1.6)
P [auth Q]	PF17135	e4d5yQ1	A: a/b three-layered sandwiches	X: Ribosomal protein L13/L15p/L18e/L32e	H: Ribosomal proteins L15p and L18e (From Topology)	T: Ribosomal proteins L15p and L18e	F: PF17135	ECOD (1.6)
Q [auth R]	PF01280	e4d5yR1	A: alpha arrays	X: Ribosomal protein L19 (L19e) N-terminal domain (From Topology)	H: Ribosomal protein L19 (L19e) N-terminal domain (From Topology)	T: Ribosomal protein L19 (L19e) N-terminal domain	F: PF01280	ECOD (1.6)
Q [auth R]	PF01280	e4d5yR2	A: alpha bundles	X: Ribosomal protein L19 (L19e) C-terminal domain (From Topology)	H: Ribosomal protein L19 (L19e) C-terminal domain (From Topology)	T: Ribosomal protein L19 (L19e) C-terminal domain	F: PF01280	ECOD (1.6)
R [auth S]	F_UNCLASSIFIED	e4d5yS2	A: a+b two layers	X: GP2-like	H: RplX-like (From Topology)	T: RplX-like	F: F_UNCLASSIFIED	ECOD (1.6)
R [auth S]	PF01775	e4d5yS1	A: a+b two layers	X: GP2-like	H: RplX-like (From Topology)	T: RplX-like	F: PF01775	ECOD (1.6)
S [auth T]	PF01157	e4d5yT1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01157	ECOD (1.6)
B	PF00297	e4d5yB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF00297	ECOD (1.6)
T [auth U]	PF01776	e4d5yU1	A: a+b two layers	X: Ribosomal protein L22e (From Topology)	H: Ribosomal protein L22e (From Topology)	T: Ribosomal protein L22e	F: PF01776	ECOD (1.6)
U [auth V]	PF00238	e4d5yV1	A: beta barrels	X: Ribosomal protein L14-like	H: Ribosomal protein L14-related (From Topology)	T: Ribosomal protein L14-related	F: PF00238	ECOD (1.6)
V [auth W]	PF01246	e4d5yW1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: PF01246	ECOD (1.6)
W [auth X]	PF00276,PF03939	e4d5yX1	A: a+b two layers	X: Alpha-beta plaits	H: Ribosomal proteins S24e, L23 and L15e (From Topology)	T: Ribosomal proteins S24e, L23 and L15e	F: PF00276,PF03939	ECOD (1.6)
X [auth Y]	PF16906	e4d5yY1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF16906	ECOD (1.6)
Y [auth Z]	PF00467,PF01777	e4d5yZ1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF00467,PF01777	ECOD (1.6)
Z [auth a]	PF00828	e4d5ya1	A: a/b three-layered sandwiches	X: Ribosomal protein L13/L15p/L18e/L32e	H: Ribosomal proteins L15p and L18e (From Topology)	T: Ribosomal proteins L15p and L18e	F: PF00828	ECOD (1.6)
AA [auth b]	PF01779	e4d5yb1	A: extended segments	X: RPL29 (From Topology)	H: RPL29 (From Topology)	T: RPL29	F: PF01779	ECOD (1.6)
BA [auth c]	PF01248	e4d5yc1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: L30e-like (From Topology)	T: L30e-like	F: PF01248	ECOD (1.6)
CA [auth d]	PF01198	e4d5yd1	A: a+b two layers	X: Ribosomal protein L31e-like	H: Ribosomal protein L31e/gp120 outer domain (From Topology)	T: Ribosomal protein L31e/gp120 outer domain	F: PF01198	ECOD (1.6)
C	PF00573	e4d5yC1	A: a/b three-layered sandwiches	X: Ribosomal protein L4 (From Topology)	H: Ribosomal protein L4 (From Topology)	T: Ribosomal protein L4	F: PF00573	ECOD (1.6)
C	PF14374	e4d5yC2	A: extended segments	X: C-terminal helical region in 60S ribosomal protein L4 (L4p) (From Topology)	H: C-terminal helical region in 60S ribosomal protein L4 (L4p) (From Topology)	T: C-terminal helical region in 60S ribosomal protein L4 (L4p)	F: PF14374	ECOD (1.6)
DA [auth e]	PF01655	e4d5ye1	A: a/b three-layered sandwiches	X: Ribosomal protein L13/L15p/L18e/L32e	H: Ribosomal protein L32e (From Topology)	T: Ribosomal protein L32e	F: PF01655	ECOD (1.6)
EA [auth f]	PF01247	e4d5yf1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF01247	ECOD (1.6)
FA [auth g]	PF01199	e4d5yg1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: RPL34 (From Topology)	T: RPL34	F: PF01199	ECOD (1.6)
GA [auth h]	PF00831	e4d5yh1	A: alpha bundles	X: Long alpha-hairpin	H: Ribosomal protein L29 (L29p) (From Topology)	T: Ribosomal protein L29 (L29p)	F: PF00831	ECOD (1.6)
HA [auth i]	PF01158	e4d5yi1	A: alpha arrays	X: 60S ribosomal protein rpL36 (L36e) (From Topology)	H: 60S ribosomal protein rpL36 (L36e) (From Topology)	T: 60S ribosomal protein rpL36 (L36e)	F: PF01158	ECOD (1.6)
IA [auth j]	PF01907	e4d5yj1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF01907	ECOD (1.6)
JA [auth k]	PF01781	e4d5yk1	A: a+b two layers	X: SRP9/14-like	H: Signal recognition particle alu RNA binding heterodimer SRP9/14-related (From Topology)	T: Signal recognition particle alu RNA binding heterodimer SRP9/14-related	F: PF01781	ECOD (1.6)
KA [auth l]	PF00832	e4d5yl1	A: extended segments	X: Ribosomal protein L39e (From Topology)	H: Ribosomal protein L39e (From Topology)	T: Ribosomal protein L39e	F: PF00832	ECOD (1.6)
LA [auth m]	PF01020	e4d5ym1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF01020	ECOD (1.6)
MA [auth n]	PF05162	e4d5yn1	A: extended segments	X: Ribosomal protein L41-A (From Topology)	H: Ribosomal protein L41-A (From Topology)	T: Ribosomal protein L41-A	F: PF05162	ECOD (1.6)
D	PF14204,PF17144	e4d5yD1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF14204,PF17144	ECOD (1.6)
NA [auth o]	PF00935	e4d5yo1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF00935	ECOD (1.6)
OA [auth p]	PF01780	e4d5yp1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF01780	ECOD (1.6)
PA [auth t]	PF01778	e4d5yt1	A: a+b two layers	X: RPL28 (From Topology)	H: RPL28 (From Topology)	T: RPL28	F: PF01778	ECOD (1.6)
QA [auth u]	PF00687	e4d5yu2	A: a+b two layers	X: a+b domain in Ribosomal protein L1 (From Topology)	H: a+b domain in Ribosomal protein L1 (From Topology)	T: a+b domain in Ribosomal protein L1	F: PF00687	ECOD (1.6)
QA [auth u]	PF00687	e4d5yu1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Rossmann-like domain in Ribosomal protein L1 (From Topology)	T: Rossmann-like domain in Ribosomal protein L1	F: PF00687	ECOD (1.6)
E	PF01159	e4d5yE1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01159	ECOD (1.6)
F	PF00327,PF08079	e4d5yF1	A: a+b two layers	X: Ribosomal protein L30p/L7e (From Topology)	H: Ribosomal protein L30p/L7e (From Topology)	T: Ribosomal protein L30p/L7e	F: PF00327,PF08079	ECOD (1.6)
G	PF01248	e4d5yG1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: L30e-like (From Topology)	T: L30e-like	F: PF01248	ECOD (1.6)
H	PF00347	e4d5yH2	A: a+b two layers	X: Ribosomal protein L6 (From Topology)	H: Ribosomal protein L6 (From Topology)	T: Ribosomal protein L6	F: PF00347	ECOD (1.6)
I	PF00252	e4d5yI1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Ribosomal protein L10e	F: PF00252	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03947	Ribosomal Proteins L2, C-terminal domain (Ribosomal_L2_C)	Ribosomal Proteins L2, C-terminal domain	-	Domain
A	PF00181	Ribosomal Proteins L2, RNA binding domain (Ribosomal_L2)	Ribosomal Proteins L2, RNA binding domain	-	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

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4D5Y

Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage