Annotations: 4D4Z

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	HEAT_2_2	e4d4zB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: HEAT_2_2	ECOD (1.6)
A	HEAT_2_2	e4d4zA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: HEAT_2_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13646	HEAT repeats (HEAT_2)	HEAT repeats	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	DEOXYHYPUSINE HYDROXYLASE	oxidoreductase activity monooxygenase activity deoxyhypusine monooxygenase activity catalytic activity, acting on a protein oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen catalytic activity cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding	peptidyl-lysine modification to peptidyl-hypusine organonitrogen compound metabolic process cellular biosynthetic process peptidyl-lysine modification cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process biosynthetic process macromolecule modification organic substance biosynthetic process peptidyl-amino acid modification peptidyl-lysine modification to peptidyl-hypusine organonitrogen compound metabolic process cellular biosynthetic process peptidyl-lysine modification cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process biosynthetic process macromolecule modification organic substance biosynthetic process peptidyl-amino acid modification metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR027517	Deoxyhypusine hydroxylase	Family
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR004155	PBS lyase HEAT-like repeat	Repeat
A, B	IPR021133	HEAT, type 2	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9BU89	atypical teratoid rhabdoid tumor malignant glioma cutaneous melanoma osteosarcoma glioblastoma Sjogren syndrome

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.