4D2K

Crystal structure of DREP2 CIDE domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4d2ka1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	CAD & PB1 domains	automated matches	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
A	d4d2ka2	Artifacts	Tags	Tags	Tags	C-terminal Tags	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
B	d4d2kb1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	CAD & PB1 domains	automated matches	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
B	d4d2kb2	Artifacts	Tags	Tags	Tags	C-terminal Tags	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
C	d4d2kc1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	CAD & PB1 domains	automated matches	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
C	d4d2kc2	Artifacts	Tags	Tags	Tags	C-terminal Tags	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
D	d4d2kd1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	CAD & PB1 domains	automated matches	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
D	d4d2kd2	Artifacts	Tags	Tags	Tags	C-terminal Tags	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CAD domain	8061478	4000979	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	CAD & PB1 domains	8061479	3000318	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	CAD & PB1 domains	8061479	3000318	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	CAD & PB1 domains	8061479	3000318	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	CAD & PB1 domains	8061479	3000318	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02017	e4d2kA1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF02017	ECOD (1.6)
B	PF02017	e4d2kB1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF02017	ECOD (1.6)
C	PF02017	e4d2kC1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF02017	ECOD (1.6)
D	PF02017	e4d2kD1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF02017	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.10	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (4.3.0)
B	3.10.20.10	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (4.3.0)
C	3.10.20.10	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (4.3.0)
D	3.10.20.10	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02017	CIDE-N domain (CIDE-N)	CIDE-N domain	This domain is found in CAD nuclease Swiss:O76075 , ICAD Swiss:O00273 the inhibitor of CAD nuclease. The two proteins interact through this domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	DREP2	-	cellular process apoptotic process cell death programmed cell death regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation regulation of programmed cell death	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003508	CIDE-N domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.