Annotations: 4CVH

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EUF08593	e4cvhA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: EUF08593	ECOD (1.6)
A	IspD	e4cvhA1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: IspD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01128	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD)	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	Family
A	PF18706	D-ribitol-5-phosphate cytidylyltransferase C-terminal domain (ISPD_C)	D-ribitol-5-phosphate cytidylyltransferase C-terminal domain	This domain is located at the C-terminal region of ISPD (isoprenoid synthase domain containing protein, EC:2.7.7.40), Pfam:PF01128. Structural homologs can be found in two distinct alpha/beta protein families including the seven-stranded NAD(P) (H)-d ...	This domain is located at the C-terminal region of ISPD (isoprenoid synthase domain containing protein, EC:2.7.7.40), Pfam:PF01128. Structural homologs can be found in two distinct alpha/beta protein families including the seven-stranded NAD(P) (H)-dependent short-chain dehydrogenases/reductases and five-stranded response regulator proteins involved in bacterial sensing systems [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ISOPRENOID SYNTHASE DOMAIN-CONTAINING PROTEIN	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity D-ribitol-5-phosphate cytidylyltransferase activity cytidylyltransferase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	protein mannosylation cellular biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process protein modification process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular metabolic process glycoprotein biosynthetic process primary metabolic process glycoprotein metabolic process protein mannosylation cellular biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process protein modification process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular metabolic process glycoprotein biosynthetic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process biosynthetic process protein O-linked mannosylation glycosylation mannosylation macromolecule modification macromolecule glycosylation protein O-linked glycosylation metabolic process cellular process macromolecule metabolic process isoprenoid biosynthetic process lipid biosynthetic process cellular lipid metabolic process lipid metabolic process isoprenoid metabolic process multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR034683	Cytidylyltransferase IspD/TarI	Family
A	IPR018294	4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site	Conserved Site
A	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A	IPR040635	D-ribitol-5-phosphate cytidylyltransferase, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: A4D126	autosomal recessive limb-girdle muscular dystrophy type 2U hydrocephalus limb-girdle muscular dystrophy muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 7 myopathy congenital muscular dystrophy muscular dystrophy-dystroglycanopathy, type A communicating hydrocephalus Eye Abnormalities lissencephaly spectrum disorders obstructive hydrocephalus muscular disease muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 congenital hydrocephalus muscular dystrophy autosomal recessive limb-girdle muscular dystrophy type 2U hydrocephalus limb-girdle muscular dystrophy muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 7 myopathy congenital muscular dystrophy muscular dystrophy-dystroglycanopathy, type A communicating hydrocephalus Eye Abnormalities lissencephaly spectrum disorders obstructive hydrocephalus muscular disease muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 congenital hydrocephalus muscular dystrophy cataract muscle tissue disease muscular dystrophy-dystroglycanopathy arthrogryposis congenital disorder of glycosylation Creutzfeldt Jacob disease intellectual disability

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.