4CQ4

C-terminal fragment of Af1503-sol: transmembrane receptor Af1503 from Archaeoglobus fulgidus engineered for solubility

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	HAMP domain-like	8033490	3001372	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HAMP domain-like	8033490	3001372	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	HAMP domain-like	8033490	3001372	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HAMP domain-like	8033490	3001372	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00672	e4cq4A2	A: alpha duplicates or obligate multimers	X: HAMP domain (From Topology)	H: HAMP domain (From Topology)	T: HAMP domain	F: PF00672	ECOD (1.6)
A	F_UNCLASSIFIED	e4cq4A1	A: extended segments	X: AF1503 pre-HAMP domain (From Topology)	H: AF1503 pre-HAMP domain (From Topology)	T: AF1503 pre-HAMP domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00672	e4cq4B1	A: alpha duplicates or obligate multimers	X: HAMP domain (From Topology)	H: HAMP domain (From Topology)	T: HAMP domain	F: PF00672	ECOD (1.6)
B	F_UNCLASSIFIED	e4cq4B2	A: extended segments	X: AF1503 pre-HAMP domain (From Topology)	H: AF1503 pre-HAMP domain (From Topology)	T: AF1503 pre-HAMP domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF00672	e4cq4C1	A: alpha duplicates or obligate multimers	X: HAMP domain (From Topology)	H: HAMP domain (From Topology)	T: HAMP domain	F: PF00672	ECOD (1.6)
C	F_UNCLASSIFIED	e4cq4C2	A: extended segments	X: AF1503 pre-HAMP domain (From Topology)	H: AF1503 pre-HAMP domain (From Topology)	T: AF1503 pre-HAMP domain	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF00672	e4cq4D1	A: alpha duplicates or obligate multimers	X: HAMP domain (From Topology)	H: HAMP domain (From Topology)	T: HAMP domain	F: PF00672	ECOD (1.6)
D	F_UNCLASSIFIED	e4cq4D2	A: extended segments	X: AF1503 pre-HAMP domain (From Topology)	H: AF1503 pre-HAMP domain (From Topology)	T: AF1503 pre-HAMP domain	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.340.10	Special	Helix non-globular	hypothetical protein mp506/mpn330, domain 1		CATH (4.3.0)
B	6.10.340.10	Special	Helix non-globular	hypothetical protein mp506/mpn330, domain 1		CATH (4.3.0)
C	6.10.340.10	Special	Helix non-globular	hypothetical protein mp506/mpn330, domain 1		CATH (4.3.0)
D	6.10.340.10	Special	Helix non-globular	hypothetical protein mp506/mpn330, domain 1		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00672	HAMP domain (HAMP)	HAMP domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	ENGINEERED VERSION OF TRANSMEMBRANE RECEPTOR AF1503	cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular process signal transduction cell communication	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003660	HAMP domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.