Annotations: 4CPC

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SYCP3-like	8104057	3002813	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SYCP3-like	8104057	3002813	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SYCP3-like	8104057	3002813	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SYCP3-like	8104057	3002813	SCOP2B (2022-06-29)
E	SCOP2 Family	SYCP3	8046470	4005101	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	SYCP3-like	8104057	3002813	SCOP2 (2022-06-29)
F	SCOP2B Superfamily	SYCP3-like	8104057	3002813	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	SYCP3-like	8104057	3002813	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	SYCP3-like	8104057	3002813	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF04803	Cor1/Xlr/Xmr conserved region (Cor1)	Cor1/Xlr/Xmr conserved region	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	SYNAPTONEMAL COMPLEX PROTEIN 3	DNA binding binding organic cyclic compound binding nucleic acid binding	developmental process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation male gamete generation cell differentiation anatomical structure development developmental process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation male gamete generation cell differentiation anatomical structure development germ cell development cellular process cellular component organization protein-DNA complex organization chromatin organization cellular component organization or biogenesis sperm DNA condensation protein-containing complex organization nucleus organization organelle organization spermatid nucleus differentiation male meiosis I organelle fission meiotic cell cycle male meiotic nuclear division meiotic cell cycle process nuclear division meiosis I meiosis I cell cycle process meiotic nuclear division cell cycle cell cycle process cell division	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome, centromeric region chromosome cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear chromosome intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome, centromeric region chromosome cellular anatomical entity chromosomal region non-membrane-bounded organelle membrane-bounded organelle condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen synaptonemal structure synaptonemal complex condensed chromosome nuclear lumen lateral element

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR006888	XLR/SYCP3/FAM9 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: Q8IZU3	azoospermia spermatogenic failure 4 Abortion, Habitual habitual spontaneous abortion osteosarcoma infertility disorder male infertility

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.