Annotations: 4CN0

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e4cn0A1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
B	PF00595	e4cn0B1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PROTEIN AHNAK2	-	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process RNA splicing regulation of biological process cellular metabolic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process RNA splicing regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of RNA splicing gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery sarcolemma plasma membrane membrane T-tubule intracellular organelle costamere organelle intracellular non-membrane-bounded organelle contractile muscle fiber intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery sarcolemma plasma membrane membrane T-tubule intracellular organelle costamere organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001478	PDZ domain	Domain
A, B	IPR036034	PDZ superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8IVF2	ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor ulcerative colitis astrocytic tumor ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant glioma medulloblastoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis cutaneous lupus erythematosus ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor ulcerative colitis astrocytic tumor ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant glioma medulloblastoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis cutaneous lupus erythematosus esophageal adenocarcinoma large cell medulloblastoma malignant colon neoplasm malignant mesothelioma myopathy oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma periodontitis rheumatoid arthritis Duchenne muscular dystrophy glioblastoma lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm nasopharyngeal carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.