4CDO

Crystal structure of PQBP1 bound to spliceosomal U5-15kD

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Thioredoxin-like	8044390	3000031	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	Thioredoxin-like	8044390	3000031	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02966	e4cdoA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02966	ECOD (1.6)
B [auth C]	PF02966	e4cdoC1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02966	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
B [auth C]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C]	PF02966	Mitosis protein DIM1 (DIM1)	Mitosis protein DIM1	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C]	THIOREDOXIN-LIKE PROTEIN 4A, POLYGLUTAMINE-BINDING PROTEIN	DNA binding binding organic cyclic compound binding nucleic acid binding double-stranded DNA binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity ribonucleoprotein complex binding protein-containing complex binding	regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus positive regulation of immune system process regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process regulation of defense response to virus defense response to virus positive regulation of defense response to virus by host regulation of defense response to virus by host response to virus regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of developmental process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation dendrite development neuron projection morphogenesis regulation of dendrite morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis regulation of anatomical structure morphogenesis system development developmental process plasma membrane bounded cell projection organization regulation of cell projection organization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis regulation of dendrite development neuron development regulation of plasma membrane bounded cell projection organization cellular response to nitrogen compound cellular response to stimulus response to organic substance cellular response to dsRNA cellular response to exogenous dsRNA cellular response to organic cyclic compound response to dsRNA response to nitrogen compound response to exogenous dsRNA cellular response to chemical stimulus response to chemical cellular response to organic substance response to organic cyclic compound positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of type I interferon production type I interferon production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production positive regulation of cellular biosynthetic process regulation of type I interferon production RNA processing RNA splicing regulation of RNA splicing alternative mRNA splicing, via spliceosome mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile cell cycle ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly protein-containing complex organization cell division	neuron projection cytoplasm intracellular anatomical structure cytoplasmic ribonucleoprotein granule neuron projection cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection ribonucleoprotein granule intracellular organelle cell projection organelle neuronal ribonucleoprotein granule intracellular non-membrane-bounded organelle neuron projection cytoplasm intracellular anatomical structure cytoplasmic ribonucleoprotein granule neuron projection cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection ribonucleoprotein granule intracellular organelle cell projection organelle neuronal ribonucleoprotein granule intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex protein-containing complex nuclear protein-containing complex U2-type precatalytic spliceosome spliceosomal complex ribonucleoprotein complex precatalytic spliceosome cytosol U5 snRNP spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C]	IPR036020	WW domain superfamily	Homologous Superfamily
A, B [auth C]	IPR001202	WW domain	Domain
A, B [auth C]	IPR004123	Dim1 family	Family
A, B [auth C]	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth C]	Pharos: P83876	Renpenning syndrome atrial septal defect microcephaly hereditary spastic paraplegia autism, susceptibility to, X-linked 2 intellectual disability plasma cell myeloma Spastic Paraplegia, Hereditary coloboma malignant glioma microlissencephaly ovarian cancer X-linked intellectual disability, Golabi-Ito-hall type colorectal cancer hamel cerebro-palato-cardiac syndrome Renpenning syndrome atrial septal defect microcephaly hereditary spastic paraplegia autism, susceptibility to, X-linked 2 intellectual disability plasma cell myeloma Spastic Paraplegia, Hereditary coloboma malignant glioma microlissencephaly ovarian cancer X-linked intellectual disability, Golabi-Ito-hall type colorectal cancer hamel cerebro-palato-cardiac syndrome osteosarcoma psoriasis Sjogren syndrome X-linked syndromic intellectual disability genetic endocrine growth disease Burn-Mckeown syndrome choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome astrocytic tumor choanal atresia glioblastoma malignant ependymoma ovarian cancer atypical teratoid rhabdoid tumor intellectual disability malignant glioma plasma cell myeloma diabetes mellitus lung cancer osteosarcoma psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.