Annotations: 4C9V

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4c9vb_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Growth factor receptor domain	automated matches	automated matches	WESTERN CLAWED FROG (Xenopus tropicalis ) [TaxId: 8364 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Growth factor receptor domain-like	8052294	3000398	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF18212	e4c9vA1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: PF18212	ECOD (1.6)
B	PF15913	e4c9vB1	A: few secondary structure elements	X: EGF-like	H: Growth factor receptor domain (From Topology)	T: Growth factor receptor domain	F: PF15913	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.50.30.30	Alpha Beta	3-Layer(bba) Sandwich	Glucose Oxidase	domain 1	CATH (4.3.0)
B	2.10.220.10	Mainly Beta	Ribbon	Hormone Receptor, Insulin-like Growth Factor Receptor 1	Chain A domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF15913	Furin-like repeat, cysteine-rich (Furin-like_2)	Furin-like repeat, cysteine-rich	The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	RNF43	-	-	-
B	R-SPONDIN-2	heparin binding glycosaminoglycan binding binding carbohydrate derivative binding sulfur compound binding	developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development fin development limb development pectoral fin development appendage development cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development fin development limb development pectoral fin development appendage development cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell communication cellular process signal transduction Wnt signaling pathway medial fin development caudal fin development dorsal fin development pelvic fin development anal fin development	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
B	IPR043601	R-spondin, Fu-CRD domain	Domain
B	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
B	IPR006212	Furin-like repeat	Repeat
B	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
B	IPR044004	Spondin-like TSP1 domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.