Annotations: 4C9R

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4c9rb_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Growth factor receptor domain	automated matches	automated matches	WESTERN CLAWED FROG (Xenopus tropicalis ) [TaxId: 8364 ],	SCOPe (2.08)
D	d4c9rd1	Small proteins	Knottins (small inhibitors, toxins, lectins)	Growth factor receptor domain	automated matches	automated matches	WESTERN CLAWED FROG (Xenopus tropicalis ) [TaxId: 8364 ],	SCOPe (2.08)
D	d4c9rd2	Artifacts	Tags	Tags	Tags	C-terminal Tags	WESTERN CLAWED FROG (Xenopus tropicalis ) [TaxId: 8364 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Furin-like repeat	8044726	4004103	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Growth factor receptor domain-like	8052294	3000398	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Growth factor receptor domain-like	8052294	3000398	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PA_like	e4c9rA1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: PA_like	ECOD (1.6)
C	PA_like	e4c9rC1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: PA_like	ECOD (1.6)
B	Furin-like_2	e4c9rB1	A: few secondary structure elements	X: EGF-like	H: Growth factor receptor domain (From Topology)	T: Growth factor receptor domain	F: Furin-like_2	ECOD (1.6)
D	Furin-like_2	e4c9rD1	A: few secondary structure elements	X: EGF-like	H: Growth factor receptor domain (From Topology)	T: Growth factor receptor domain	F: Furin-like_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.50.30.30	Alpha Beta	3-Layer(bba) Sandwich	Glucose Oxidase	domain 1	CATH (4.3.0)
C	3.50.30.30	Alpha Beta	3-Layer(bba) Sandwich	Glucose Oxidase	domain 1	CATH (4.3.0)
B	2.10.220.10	Mainly Beta	Ribbon	Hormone Receptor, Insulin-like Growth Factor Receptor 1	Chain A domain 2	CATH (4.3.0)
D	2.10.220.10	Mainly Beta	Ribbon	Hormone Receptor, Insulin-like Growth Factor Receptor 1	Chain A domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF18212	ZNRF-3 Ectodomain (ZNRF_3_ecto)	ZNRF-3 Ectodomain	This domain is found in ZNRF-3 protein present in Danio rerio. ZNRF-3 is a transmembrane E3 ubiquitin ligase that antagonizes Wnt signalling, the signalling system used to mediate Rspo protein actions. ZNFR3 and RNF43, alongside the Rspo proteins, ha ...	This domain is found in ZNRF-3 protein present in Danio rerio. ZNRF-3 is a transmembrane E3 ubiquitin ligase that antagonizes Wnt signalling, the signalling system used to mediate Rspo protein actions. ZNFR3 and RNF43, alongside the Rspo proteins, have emerged as a system with therapeutic potential for a number of pathological processes. This domain is known as the ectodomain [1].	Domain
B, D	PF15913	Furin-like repeat, cysteine-rich (Furin-like_2)	Furin-like repeat, cysteine-rich	The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	E3 UBIQUITIN-PROTEIN LIGASE ZNRF3	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding binding metal ion binding small molecule binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process developmental process multicellular organism development multicellular organismal process limb development appendage development anatomical structure development stem cell proliferation cell population proliferation cellular process cellular response to stimulus receptor catabolic process regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication cellular catabolic process negative regulation of Wnt signaling pathway receptor metabolic process negative regulation of cellular process signal transduction Wnt signaling pathway regulation of signaling regulation of biological process cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus cellular metabolic process biological regulation negative regulation of signal transduction regulation of response to stimulus Wnt receptor catabolic process regulation of cell communication regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal non-canonical Wnt signaling pathway regulation of non-canonical Wnt signaling pathway negative regulation of non-canonical Wnt signaling pathway	cell periphery plasma membrane membrane cellular anatomical entity
B, D	R-SPONDIN-2	heparin binding glycosaminoglycan binding binding carbohydrate derivative binding sulfur compound binding	developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development fin development limb development pectoral fin development appendage development cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development fin development limb development pectoral fin development appendage development cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell communication cellular process signal transduction Wnt signaling pathway medial fin development caudal fin development dorsal fin development pelvic fin development anal fin development	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, C	IPR040700	ZNRF-3, ectodomain	Domain
A, C	IPR001841	Zinc finger, RING-type	Domain
B, D	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
B, D	IPR043601	R-spondin, Fu-CRD domain	Domain
B, D	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
B, D	IPR006212	Furin-like repeat	Repeat
B, D	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
B, D	IPR044004	Spondin-like TSP1 domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.