Annotations: 4C2X

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4c2xa1	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4c2xa3	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01233	e4c2xA1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF01233	ECOD (1.6)
A	PF02799	e4c2xA2	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF02799	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.630.170	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01233	Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain (NMT)	Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain	The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	Domain
A	PF02799	Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain (NMT_C)	Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain	The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 2	catalytic activity, acting on a protein peptidyl-lysine N6-myristoyltransferase activity myristoyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity glycylpeptide N-tetradecanoyltransferase activity N-acyltransferase activity	cellular biosynthetic process lipoprotein biosynthetic process lipoprotein metabolic process organonitrogen compound biosynthetic process N-terminal protein lipidation N-terminal protein myristoylation protein acylation protein lipidation organic substance metabolic process protein myristoylation peptidyl-amino acid modification organic substance biosynthetic process N-terminal peptidyl-glycine N-myristoylation protein metabolic process cellular biosynthetic process lipoprotein biosynthetic process lipoprotein metabolic process organonitrogen compound biosynthetic process N-terminal protein lipidation N-terminal protein myristoylation protein acylation protein lipidation organic substance metabolic process protein myristoylation peptidyl-amino acid modification organic substance biosynthetic process N-terminal peptidyl-glycine N-myristoylation protein metabolic process protein modification process organonitrogen compound metabolic process cellular metabolic process primary metabolic process macromolecule biosynthetic process biosynthetic process N-terminal protein amino acid modification peptidyl-glycine modification macromolecule modification metabolic process cellular process macromolecule metabolic process cellular response to stimulus response to light stimulus regulation of cellular process response to stimulus regulation of response to external stimulus signaling regulation of opsin-mediated signaling pathway regulation of signal transduction detection of abiotic stimulus cellular response to environmental stimulus cell communication cellular response to light stimulus signal transduction regulation of G protein-coupled receptor signaling pathway rhodopsin mediated signaling pathway detection of light stimulus phototransduction detection of external stimulus regulation of biological process regulation of signaling biological regulation detection of visible light response to external stimulus cellular response to radiation detection of stimulus regulation of response to stimulus regulation of cell communication response to radiation response to abiotic stimulus G protein-coupled receptor signaling pathway cellular response to abiotic stimulus phototransduction, visible light intracellular transport of virus viral process viral life cycle transport of virus	host cellular component host cell cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cytosol cell periphery plasma membrane host cellular component host cell cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR022676	Glycylpeptide N-tetradecanoyltransferase, N-terminal	Domain
A	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A	IPR022677	Glycylpeptide N-tetradecanoyltransferase, C-terminal	Domain
A	IPR000903	Glycylpeptide N-tetradecanoyltransferase	Family
A	IPR022678	Glycylpeptide N-tetradecanoyltransferase, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O60551	pilocytic astrocytoma subependymal giant cell astrocytoma atopic eczema breast carcinoma corpus luteum cyst head and neck cancer lung cancer malignant mesothelioma ovarian cyst primitive neuroectodermal tumor ulcerative colitis atypical teratoid rhabdoid tumor breast fibroadenoma ductal breast carcinoma in situ invasive ductal breast carcinoma pilocytic astrocytoma subependymal giant cell astrocytoma atopic eczema breast carcinoma corpus luteum cyst head and neck cancer lung cancer malignant mesothelioma ovarian cyst primitive neuroectodermal tumor ulcerative colitis atypical teratoid rhabdoid tumor breast fibroadenoma ductal breast carcinoma in situ invasive ductal breast carcinoma malignant ependymoma medulloblastoma Ovarian Cysts psoriasis breast cancer chronic kidney disease glioblastoma large cell medulloblastoma malignant glioma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.