4B93

Complex of Vamp7 cytoplasmic domain with 2nd ankyrin repeat domain of Varp

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF00957,PF13774e4b93A1 A: a+b three layersX: Profilin-likeH: profilin-like (From Topology)T: profilin-likeF: PF00957,PF13774ECOD (1.6)
BPF12796e4b93B1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Ankyrin repeat (From Topology)T: Ankyrin repeatF: PF12796ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.450.50 Alpha Beta 2-Layer Sandwich Beta-Lactamase Longin domainCATH (4.3.0)
B1.25.40.20 Mainly Alpha Alpha Horseshoe Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat Ankyrin repeat-containing domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF13774Regulated-SNARE-like domain (Longin)Regulated-SNARE-like domainLongin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex [1]. Longins are the only ...Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex [1]. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterised by a conserved N-terminal domain with a profilin-like fold called a longin domain [2].
Domain
PF12796Ankyrin repeats (3 copies) (Ank_2)Ankyrin repeats (3 copies)- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
VESICLE-ASSOCIATED MEMBRANE PROTEIN 7
ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR010908Longin domainDomain
IPR042855v-SNARE, coiled-coil homology domainDomain
IPR001388Synaptobrevin-likeFamily
IPR011012Longin-like domain superfamilyHomologous Superfamily
IPR036770Ankyrin repeat-containing domain superfamilyHomologous Superfamily
IPR003123VPS9 domainDomain
IPR002110Ankyrin repeatRepeat
IPR037191VPS9 domain superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
Pharos:  Q96NW4