Annotations: 4B8L

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4b8la_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	AFRICAN CLAWED FROG (Xenopus laevis ) [TaxId: 8355 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8062543	3000066	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	INCENP ARK binding region-like	8057049	3002383	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00069	e4b8lA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
B [auth D]	6.10.250.2990	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain
B [auth D]	PF03941	Inner centromere protein, ARK binding region (INCENP_ARK-bind)	Inner centromere protein, ARK binding region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	AURORA KINASE B-A	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity histone H3 kinase activity histone modifying activity histone H3S10 kinase activity histone kinase activity cation binding metal ion binding	mitotic spindle elongation spindle midzone assembly spindle elongation non-membrane-bounded organelle assembly microtubule cytoskeleton organization mitotic cell cycle cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis mitotic spindle elongation spindle midzone assembly spindle elongation non-membrane-bounded organelle assembly microtubule cytoskeleton organization mitotic cell cycle cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cell cycle cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation cellular process microtubule-based process mitotic spindle midzone assembly cytoskeleton organization regulation of cytokinesis regulation of biological process regulation of cellular process negative regulation of cytokinesis regulation of cell cycle process biological regulation negative regulation of biological process negative regulation of cell cycle cytokinesis negative regulation of cell cycle process regulation of cell division negative regulation of cell division negative regulation of cellular process cell division regulation of cell cycle membrane organization cytoskeleton-dependent cytokinesis cleavage furrow formation cytokinetic process membrane invagination plasma membrane invagination positive regulation of cell division positive regulation of biological process positive regulation of cell cycle positive regulation of cytokinesis positive regulation of cell cycle process positive regulation of cellular process protein localization cellular localization protein localization to chromosome, centromeric region localization protein localization to kinetochore protein localization to chromosome protein localization to condensed chromosome protein localization to organelle cellular macromolecule localization macromolecule localization cellular response to stimulus regulation of cell cycle phase transition response to stimulus signaling G2/M transition of mitotic cell cycle cell cycle phase transition intracellular signal transduction negative regulation of mitotic cell cycle cell communication regulation of mitotic cell cycle negative regulation of cell cycle phase transition signal transduction mitotic cytokinesis checkpoint signaling cell cycle G2/M phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle G2/M phase transition cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein phosphorylation phosphorylation cellular metabolic process phosphate-containing compound metabolic process phosphorus metabolic process response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV positive regulation of organelle organization regulation of chromosome segregation regulation of cellular component organization positive regulation of cellular component organization positive regulation of chromosome segregation regulation of chromosome organization positive regulation of mitotic sister chromatid segregation regulation of organelle organization positive regulation of chromosome organization regulation of mitotic sister chromatid segregation regulation of sister chromatid segregation negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process regulation of B cell apoptotic process negative regulation of programmed cell death leukocyte apoptotic process regulation of apoptotic process B cell apoptotic process regulation of programmed cell death cell death negative regulation of B cell apoptotic process lymphocyte apoptotic process negative regulation of apoptotic process negative regulation of leukocyte apoptotic process apoptotic process programmed cell death negative regulation of lymphocyte apoptotic process developmental process multicellular organism development multicellular organismal process abscission anatomical structure development	midbody cellular anatomical entity intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome, centromeric region chromosome chromosomal region non-membrane-bounded organelle protein-containing complex protein-DNA complex chromatin chromosome passenger complex midbody cellular anatomical entity intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome, centromeric region chromosome chromosomal region non-membrane-bounded organelle protein-containing complex protein-DNA complex chromatin chromosome passenger complex cytoskeleton microtubule associated complex microtubule cytoskeleton kinetochore condensed chromosome, centromeric region supramolecular complex condensed chromosome membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B [auth D]	INNER CENTROMERE PROTEIN A	protein binding binding kinase binding enzyme binding protein kinase binding	mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process chromosome segregation organelle assembly non-membrane-bounded organelle assembly microtubule cytoskeleton organization spindle assembly mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process chromosome segregation organelle assembly non-membrane-bounded organelle assembly microtubule cytoskeleton organization spindle assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly microtubule-based process cellular component organization or biogenesis cytoskeleton organization spindle organization	midbody cellular anatomical entity protein-containing complex intracellular anatomical structure chromosome passenger complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region midbody cellular anatomical entity protein-containing complex intracellular anatomical structure chromosome passenger complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome spindle cytoplasm polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer membrane-bounded organelle nucleus intracellular membrane-bounded organelle pericentric heterochromatin protein-DNA complex chromatin heterochromatin

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR030616	Aurora kinase-like	Family
A	IPR000719	Protein kinase domain	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B [auth D]	IPR022006	Chromosome passenger complex (CPC) protein INCENP N-terminal	Domain
B [auth D]	IPR005635	Inner centromere protein, ARK-binding domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.