Annotations: 4B56

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	F_UNCLASSIFIED	e4b56B3	A: a+b two layers	X: Alpha-beta plaits	H: Phosphonoacetate hydrolase insertion domain (From Topology)	T: Phosphonoacetate hydrolase insertion domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF01663	e4b56B1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF01663	ECOD (1.6)
B	PF01223	e4b56B2	A: few secondary structure elements	X: His-Me finger endonucleases (From Homology)	H: His-Me finger endonucleases	T: His-Me finger endonucleases	F: PF01223	ECOD (1.6)
A	PF01663	e4b56A1	A: a+b two layers	X: Alpha-beta plaits	H: Phosphonoacetate hydrolase insertion domain (From Topology)	T: Phosphonoacetate hydrolase insertion domain	F: PF01663	ECOD (1.6)
A	PF01663	e4b56A6	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF01663	ECOD (1.6)
A	PF01223	e4b56A4	A: few secondary structure elements	X: His-Me finger endonucleases (From Homology)	H: His-Me finger endonucleases	T: His-Me finger endonucleases	F: PF01223	ECOD (1.6)
A	PF01033	e4b56A3	A: few secondary structure elements	X: Somatomedin B domain (From Topology)	H: Somatomedin B domain (From Topology)	T: Somatomedin B domain	F: PF01033	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	CATH (4.3.0)
B	3.30.1360.180	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
B	3.40.570.10	Alpha Beta	3-Layer(aba) Sandwich	Extracellular Endonuclease	Chain A	CATH (4.3.0)
A	3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	CATH (4.3.0)
A	3.40.570.10	Alpha Beta	3-Layer(aba) Sandwich	Extracellular Endonuclease	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01033	Somatomedin B domain (Somatomedin_B)	Somatomedin B domain	-	Family
A, B	PF01223	DNA/RNA non-specific endonuclease (Endonuclease_NS)	DNA/RNA non-specific endonuclease	-	Domain
A, B	PF01663	Type I phosphodiesterase / nucleotide pyrophosphatase (Phosphodiest)	Type I phosphodiesterase / nucleotide pyrophosphatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1	binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity ATP diphosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity UTP diphosphatase activity cation binding calcium ion binding metal ion binding dinucleotide phosphatase activity identical protein binding protein binding protein homodimerization activity protein dimerization activity coenzyme A diphosphatase activity GTP diphosphatase activity signaling receptor binding insulin receptor binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity cargo receptor activity scavenger receptor activity phosphoric diester hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cyclic-nucleotide phosphodiesterase activity nuclease activity phosphodiesterase I activity exonuclease activity polysaccharide binding carbohydrate binding transition metal ion binding zinc ion binding cyclic-GMP-AMP hydrolase activity	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development heart development circulatory system development ossification bone mineralization developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development heart development circulatory system development ossification bone mineralization biomineral tissue development regulation of body fluid levels secretion by tissue secretion transport biological regulation mucus secretion establishment of localization localization body fluid secretion regulation of biological quality response to stimulus response to endogenous stimulus response to growth factor response to platelet-derived growth factor endochondral ossification replacement ossification endochondral bone morphogenesis anatomical structure morphogenesis skeletal system morphogenesis animal organ morphogenesis bone morphogenesis bone development cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation immune system process cell differentiation T cell differentiation cellular process leukocyte differentiation regulation of multicellular organismal development regulation of biological process regulation of developmental process regulation of biomineral tissue development regulation of bone mineralization regulation of multicellular organismal process regulation of ossification regulation of cellular process negative regulation of biological process regulation of generation of precursor metabolites and energy negative regulation of cellular metabolic process regulation of primary metabolic process organic substance biosynthetic process negative regulation of carbohydrate metabolic process negative regulation of glycogen metabolic process carbohydrate biosynthetic process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process energy reserve metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of glycogen metabolic process regulation of metabolic process regulation of glycogen biosynthetic process negative regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds cellular biosynthetic process regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process organic substance metabolic process glucan metabolic process negative regulation of cellular process regulation of carbohydrate metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process glycogen metabolic process generation of precursor metabolites and energy regulation of macromolecule metabolic process glycogen biosynthetic process macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process biological process involved in interspecies interaction between organisms response to other organism defense response defense response to protozoan response to external stimulus response to biotic stimulus response to protozoan defense response to other organism response to stress response to external biotic stimulus ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process nucleobase-containing compound metabolic process glycolytic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process organic cyclic compound metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process ADP catabolic process carboxylic acid metabolic process organic cyclic compound catabolic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process ligamentous ossification inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis cell morphogenesis odontogenesis response to wounding fat cell differentiation mRNA transcription by RNA polymerase II RNA metabolic process mRNA transcription RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression mRNA metabolic process nucleic acid metabolic process organic cyclic compound biosynthetic process system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus leukocyte activation involved in inflammatory response inflammatory response adult walking behavior adult locomotory behavior behavior adult behavior locomotory behavior walking behavior cellular response to stimulus cellular response to sodium phosphate cellular response to chemical stimulus response to chemical response to sodium phosphate cellular response to salt response to salt response to inorganic substance cell surface receptor signaling pathway signaling cell communication signal transduction collagen-activated signaling pathway tooth mineralization multicellular organism growth developmental growth growth adipose tissue development fat pad development ear morphogenesis embryonic organ morphogenesis middle ear morphogenesis ear development sensory organ development embryonic morphogenesis embryo development sensory organ morphogenesis embryonic organ development phosphate ion homeostasis intracellular phosphate ion homeostasis cellular homeostasis intracellular chemical homeostasis inorganic diphosphate transport organic substance transport inorganic anion transport negative regulation of developmental process regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of cell differentiation regulation of fat cell differentiation spinal cord development central nervous system development nervous system development nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process coenzyme A catabolic process purine nucleoside bisphosphate catabolic process nucleoside bisphosphate catabolic process coenzyme A metabolic process ribonucleoside bisphosphate catabolic process magnesium ion homeostasis apoptotic process involved in development apoptotic process cell death programmed cell death muscle cell migration vascular associated smooth muscle cell migration cell migration cell motility smooth muscle cell migration skin development pigment cell differentiation pigmentation developmental pigmentation melanocyte differentiation sensory perception of temperature stimulus organ growth bone growth multicellular organismal-level homeostasis inhibition of non-skeletal tissue mineralization anatomical structure homeostasis tissue homeostasis myeloid leukocyte differentiation macrophage differentiation neurogenesis gliogenesis glial cell differentiation myeloid cell differentiation microglia differentiation cellular localization establishment of localization in cell fatty acid metabolic process cellular lipid metabolic process lipid metabolic process response to nutrient levels response to organic substance response to organonitrogen compound response to nutrient response to oxygen-containing compound response to nitrogen compound response to vitamin response to vitamin B6 response to organic cyclic compound neuron apoptotic process blood vessel morphogenesis tube development vasculogenesis vasculature development tube morphogenesis blood vessel development response to hormone response to peptide hormone response to insulin cementum mineralization osteoclast differentiation Wnt signaling pathway cellular response to nitrogen compound cellular response to peptide hormone stimulus cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to organonitrogen compound cellular response to organic substance cellular response to insulin stimulus cellular response to hormone stimulus hexose transmembrane transport glucose import carbohydrate transport transmembrane transport glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport negative regulation of multicellular organismal process negative regulation of ossification response to bacterium response to Gram-positive bacterium oligodendrocyte apoptotic process glial cell apoptotic process articular cartilage development response to dietary excess energy homeostasis limb development appendage development post-embryonic appendage morphogenesis forelimb morphogenesis post-embryonic limb morphogenesis appendage morphogenesis post-embryonic animal morphogenesis post-embryonic forelimb morphogenesis post-embryonic development limb morphogenesis tissue morphogenesis epithelium development morphogenesis of an epithelium cell population proliferation organic phosphonate metabolic process regulation of growth regulation of cellular component organization negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth cellular component organization or biogenesis artery development aorta development bone maturation bone mineralization involved in bone maturation developmental maturation anatomical structure maturation ossification involved in bone maturation animal organ maturation negative regulation of signaling regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus negative regulation of cell communication cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway regulation of signaling negative regulation of response to stimulus regulation of insulin receptor signaling pathway negative regulation of signal transduction negative regulation of cellular response to insulin stimulus regulation of response to stimulus negative regulation of insulin receptor signaling pathway regulation of cell communication muscle cell proliferation smooth muscle cell proliferation vascular associated smooth muscle cell proliferation immune response inflammatory response to antigenic stimulus kidney development renal system development tissue remodeling bone remodeling bone resorption diphosphate metabolic process glucose homeostasis carbohydrate homeostasis muscle cell cellular homeostasis nucleoside triphosphate catabolic process osteoblast differentiation smoothened signaling pathway mature B cell differentiation B cell activation involved in immune response cell activation involved in immune response B cell differentiation leukocyte activation involved in immune response lymphocyte activation involved in immune response mature B cell differentiation involved in immune response B cell activation immune effector process plasma cell differentiation regulation of localization negative regulation of transport negative regulation of transmembrane transport regulation of glucose import regulation of transport negative regulation of glucose import regulation of glucose transmembrane transport negative regulation of glucose transmembrane transport regulation of transmembrane transport oligodendrocyte development central nervous system myelination glial cell development myelination axon ensheathment in central nervous system oligodendrocyte differentiation axon ensheathment ensheathment of neurons regulation of hormone levels hormone metabolic process bone trabecula formation bone trabecula morphogenesis anatomical structure formation involved in morphogenesis trabecula formation trabecula morphogenesis regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process regulation of phosphate metabolic process negative regulation of protein modification process protein metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation protein autophosphorylation phosphorylation regulation of protein metabolic process regulation of protein autophosphorylation negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation negative regulation of protein autophosphorylation regulation of RNA metabolic process negative regulation of smoothened signaling pathway negative regulation of hh target transcription factor activity regulation of nucleobase-containing compound metabolic process regulation of smoothened signaling pathway regulation of gene expression regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription regulation of RNA biosynthetic process hematopoietic stem cell migration hematopoietic stem cell migration to bone marrow determination of adult lifespan response to fibroblast growth factor cellular response to growth factor stimulus fibroblast growth factor receptor signaling pathway cellular response to fibroblast growth factor stimulus fat-soluble vitamin metabolic process organic hydroxy compound metabolic process steroid metabolic process alcohol metabolic process vitamin D3 metabolic process vitamin D metabolic process vitamin metabolic process secondary alcohol metabolic process response to organophosphorus response to ATP response to purine-containing compound cell projection organization neuron projection development regeneration response to axon injury neuron projection regeneration axon regeneration neuron differentiation cellular response to stress plasma membrane bounded cell projection organization axon development generation of neurons neuron development glial cell migration microglial cell migration macrophage migration leukocyte migration mononuclear cell migration myeloid leukocyte migration sequestering of triglyceride macromolecule localization lipid storage lipid localization maintenance of location B cell homeostasis leukocyte homeostasis B-1 B cell homeostasis homeostasis of number of cells lymphocyte homeostasis purine ribonucleoside bisphosphate metabolic process sulfur compound metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process organelle organization mitochondrion organization positive regulation of cell communication modulation of chemical synaptic transmission positive regulation of biological process long-term synaptic potentiation synaptic signaling positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling positive regulation of signaling negative regulation of biomineral tissue development negative regulation of bone mineralization response to metal ion response to magnesium ion	basal dendrite somatodendritic compartment cell projection dendrite dendritic tree neuron projection cellular anatomical entity plasma membrane bounded cell projection cell body extracellular region extracellular space cell surface cell periphery plasma membrane basal dendrite somatodendritic compartment cell projection dendrite dendritic tree neuron projection cellular anatomical entity plasma membrane bounded cell projection cell body extracellular region extracellular space cell surface cell periphery plasma membrane membrane apical dendrite basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane neuronal cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017850	Alkaline-phosphatase-like, core domain superfamily	Homologous Superfamily
A, B	IPR020436	Somatomedin B domain, chordata	Domain
A, B	IPR020821	Extracellular Endonuclease, subunit A	Domain
A, B	IPR036024	Somatomedin B-like domain superfamily	Homologous Superfamily
A, B	IPR001212	Somatomedin B domain	Domain
A, B	IPR002591	Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase	Family
A, B	IPR044925	His-Me finger superfamily	Homologous Superfamily
A, B	IPR001604	DNA/RNA non-specific endonuclease	Domain
A, B	IPR044929	DNA/RNA non-specific endonuclease superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.