Annotations: 4A1S

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13424	e4a1sA4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF13424	ECOD (1.6)
B	PF13424	e4a1sB4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF13424	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
B	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13374	Tetratricopeptide repeat (TPR_10)	Tetratricopeptide repeat	-	Repeat
A, B	PF13424	Tetratricopeptide repeat (TPR_12)	Tetratricopeptide repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PARTNER OF INSCUTEABLE	protein binding binding protein domain specific binding G-protein alpha-subunit binding GTPase regulator activity enzyme regulator activity GDP-dissociation inhibitor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	developmental process neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process neuroblast division nervous system development asymmetric cell division generation of neurons neurogenesis multicellular organism development asymmetric neuroblast division cell differentiation anatomical structure development developmental process neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process neuroblast division nervous system development asymmetric cell division generation of neurons neurogenesis multicellular organism development asymmetric neuroblast division cell differentiation anatomical structure development cellular process cell division neural precursor cell proliferation cell fate commitment system development establishment of organelle localization cellular localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle cellular component organization localization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle cellular component organization or biogenesis microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of localization establishment of cell polarity organelle organization mitotic cell cycle process establishment of mitotic spindle orientation microtubule-based process cytoskeleton organization protein localization cell fate determination asymmetric protein localization involved in cell fate determination cellular macromolecule localization macromolecule localization basal protein localization	cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity apical part of cell cell cortex region cytoplasmic region apical cortex
C, D [auth E]	RE60102P	protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity	localization macromolecule localization RNA localization developmental process sensory organ development animal organ development anatomical structure development neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process neuroblast division nervous system development asymmetric cell division localization macromolecule localization RNA localization developmental process sensory organ development animal organ development anatomical structure development neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process neuroblast division nervous system development asymmetric cell division generation of neurons neurogenesis multicellular organism development asymmetric neuroblast division cell differentiation cellular process cell division neural precursor cell proliferation cell fate commitment system development protein localization cellular localization apical protein localization cellular macromolecule localization establishment of organelle localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle cellular component organization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle cellular component organization or biogenesis microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of localization establishment of cell polarity organelle organization mitotic cell cycle process establishment of mitotic spindle orientation microtubule-based process cytoskeleton organization Malpighian tubule development epithelium development tube development tissue development renal system development Malpighian tubule tip cell differentiation renal tubule development peripheral nervous system development muscle structure development somatic muscle development neuroblast fate commitment neuroblast differentiation cell fate determination neuroblast fate determination biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus regulation of multicellular organismal development regulation of biological process regulation of developmental process biological regulation regulation of nervous system development regulation of multicellular organismal process regulation of cellular process regulation of asymmetric cell division regulation of cell division	cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity apical part of cell cell cortex region cytoplasmic region apical cortex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B	IPR003109	GoLoco motif	Conserved Site
A, B	IPR019734	Tetratricopeptide repeat	Repeat
C, D [auth E]	IPR016024	Armadillo-type fold	Homologous Superfamily
C, D [auth E]	IPR039921	Inscuteable	Family
C, D [auth E]	IPR011989	Armadillo-like helical	Homologous Superfamily
C, D [auth E]	IPR045789	Protein inscuteable homologue, C-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.