3ZYN

Crystal structure of the N-terminal leucine rich repeats of Netrin-G Ligand-3

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ngr ectodomain-like	8073298	4002278	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	L domain-like	8073299	3001010	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	L domain-like	8073299	3001010	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LRR_8_1	e3zynA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
B	LRR_8_1	e3zynB1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
B	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4B	protein binding binding signaling receptor binding	multicellular organismal process regulation of cellular component organization regulation of cellular process regulation of postsynaptic specialization assembly cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly regulation of excitatory synapse assembly postsynaptic density organization anatomical structure development regulation of synapse structure or activity cellular component organization or biogenesis multicellular organismal process regulation of cellular component organization regulation of cellular process regulation of postsynaptic specialization assembly cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly regulation of excitatory synapse assembly postsynaptic density organization anatomical structure development regulation of synapse structure or activity cellular component organization or biogenesis synapse organization regulation of biological quality regulation of synapse assembly regulation of postsynaptic density organization system development developmental process regulation of biological process postsynapse organization organelle assembly postsynaptic specialization assembly postsynapse assembly biological regulation regulation of postsynapse organization nervous system development regulation of cellular component biogenesis regulation of organelle organization excitatory synapse assembly regulation of cell junction assembly regulation of synapse organization organelle organization cell junction organization regulation of organelle assembly cellular process postsynaptic specialization organization synapse assembly postsynaptic density assembly regulation of postsynaptic density assembly positive regulation of nervous system development positive regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process regulation of multicellular organismal process positive regulation of cellular process regulation of multicellular organismal development positive regulation of cellular component biogenesis positive regulation of cell junction assembly positive regulation of multicellular organismal process positive regulation of synapse assembly cell adhesion cell-cell adhesion synaptic membrane adhesion cell-cell adhesion via plasma-membrane adhesion molecules regulation of presynapse assembly regulation of presynapse organization presynapse organization presynapse assembly	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region presynapse presynaptic membrane axon cell projection neuron projection cerebellar mossy fiber plasma membrane bounded cell projection glutamatergic synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000372	Leucine-rich repeat N-terminal domain	Domain
A, B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B	IPR003599	Immunoglobulin subtype	Domain
A, B	IPR003598	Immunoglobulin subtype 2	Domain
A, B	IPR001611	Leucine-rich repeat	Repeat
A, B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A, B	IPR007110	Immunoglobulin-like domain	Domain
A, B	IPR013098	Immunoglobulin I-set	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.