3ZXU

Crystal structure of the Ctf19-Mcm21 kinetochore heterodimer from yeast

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RWD domain-like	8053988	3000774	SCOP2B (2022-06-29)
C	SCOP2 Family	CENP-O domain-like	8044992	4004240	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	RWD domain-like	8053988	3000774	SCOP2 (2022-06-29)
B	SCOP2 Family	CENP-P domain-like	8053992	4007624	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	RWD domain-like	8053996	3000774	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	RWD domain-like	8053997	3000774	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	RWD domain-like	8053996	3000774	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RWD domain-like	8053997	3000774	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3zxuA2	A: a+b two layers	X: Kinetochore globular domain-like (From Topology)	H: Kinetochore globular domain-like (From Topology)	T: Kinetochore globular domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF09496	e3zxuA1	A: a+b two layers	X: Kinetochore globular domain-like (From Topology)	H: Kinetochore globular domain-like (From Topology)	T: Kinetochore globular domain-like	F: PF09496	ECOD (1.6)
C	F_UNCLASSIFIED	e3zxuC2	A: a+b two layers	X: Kinetochore globular domain-like (From Topology)	H: Kinetochore globular domain-like (From Topology)	T: Kinetochore globular domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF09496	e3zxuC1	A: a+b two layers	X: Kinetochore globular domain-like (From Topology)	H: Kinetochore globular domain-like (From Topology)	T: Kinetochore globular domain-like	F: PF09496	ECOD (1.6)
B	PF22462	e3zxuB2	A: a+b two layers	X: Kinetochore globular domain-like (From Topology)	H: Kinetochore globular domain-like (From Topology)	T: Kinetochore globular domain-like	F: PF22462	ECOD (1.6)
B	PF22463	e3zxuB1	A: a+b two layers	X: Kinetochore globular domain-like (From Topology)	H: Kinetochore globular domain-like (From Topology)	T: Kinetochore globular domain-like	F: PF22463	ECOD (1.6)
D	PF22462	e3zxuD2	A: a+b two layers	X: Kinetochore globular domain-like (From Topology)	H: Kinetochore globular domain-like (From Topology)	T: Kinetochore globular domain-like	F: PF22462	ECOD (1.6)
D	PF22463	e3zxuD1	A: a+b two layers	X: Kinetochore globular domain-like (From Topology)	H: Kinetochore globular domain-like (From Topology)	T: Kinetochore globular domain-like	F: PF22463	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.12050	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	3.40.50.12050	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF09496	Cenp-O kinetochore centromere component (CENP-O)	Cenp-O kinetochore centromere component	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	MCM21	-	sexual reproduction reproductive process meiotic cell cycle cellular process cell cycle cell division protein-containing complex organization chromosome organization protein-DNA complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization organelle organization cellular component assembly sexual reproduction reproductive process meiotic cell cycle cellular process cell cycle cell division protein-containing complex organization chromosome organization protein-DNA complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization organelle organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis centromere complex assembly	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B, D	CTF19	-	sexual reproduction reproductive process meiotic cell cycle cellular process cell cycle cell division	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR018464	Centromere protein O	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.