3ZRH

Crystal structure of the Lys29, Lys33-linkage-specific TRABID OTU deubiquitinase domain reveals an Ankyrin-repeat ubiquitin binding domain (AnkUBD)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF18418	e3zrhA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF18418	ECOD (1.6)
A	PF02338	e3zrhA2	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF02338	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.560	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02338	OTU-like cysteine protease (OTU)	OTU-like cysteine protease	-	Family
A	PF18418	Ankyrin ubiquitin-binding domain (AnkUBD)	Ankyrin ubiquitin-binding domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	UBIQUITIN THIOESTERASE ZRANB1	cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity polyubiquitin modification-dependent protein binding protein binding binding modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding cation binding cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity polyubiquitin modification-dependent protein binding protein binding binding modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding cation binding ion binding metal ion binding small molecule binding	protein deubiquitination catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process organic substance metabolic process protein modification by small protein removal modification-dependent macromolecule catabolic process proteolysis protein metabolic process protein modification process organonitrogen compound catabolic process organonitrogen compound metabolic process primary metabolic process protein catabolic process protein deubiquitination catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process organic substance metabolic process protein modification by small protein removal modification-dependent macromolecule catabolic process proteolysis protein metabolic process protein modification process organonitrogen compound catabolic process organonitrogen compound metabolic process primary metabolic process protein catabolic process protein deubiquitination involved in ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process macromolecule modification metabolic process ubiquitin-dependent protein catabolic process macromolecule metabolic process post-translational protein modification organic substance catabolic process protein modification by small protein conjugation or removal cellular component organization organelle organization cellular process cellular component organization or biogenesis cytoskeleton organization cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway biological regulation regulation of response to stimulus regulation of cell communication positive regulation of signaling protein K29-linked deubiquitination developmental process anatomical structure morphogenesis regulation of developmental process anatomical structure development cell morphogenesis regulation of cell morphogenesis regulation of anatomical structure morphogenesis protein K33-linked deubiquitination cell migration cell motility protein K63-linked deubiquitination	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036443	Zinc finger, RanBP2-type superfamily	Homologous Superfamily
A	IPR049768	Ubiquitin thioesterase ZRANB1, ovarian tumor domain	Domain
A	IPR041294	Ankyrin ubiquitin-binding domain	Domain
A	IPR003323	OTU domain	Domain
A	IPR001876	Zinc finger, RanBP2-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UGI0	acute myeloid leukemia glioblastoma osteosarcoma prostate carcinoma adrenal cortex carcinoma large cell medulloblastoma ovarian cancer spina bifida atypical teratoid rhabdoid tumor malignant glioma pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.