3ZQJ

Mycobacterium tuberculosis UvrA

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	UvrA-like	8056680	4004014	SCOP2 (2022-06-29)
A	SCOP2 Family	UvrA interaction domain-like	8056686	4007668	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056683	3001550	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056684	3001550	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ABC transporter-like P-loop ATPases	8056682	3002020	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	UvrA insert domain-like	8056685	3002355	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	UvrA interaction domain-like	8056687	3002356	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056683	3001550	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056682	3002020	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056683	3001550	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	UvrA insert domain-like	8056685	3002355	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056684	3001550	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056682	3002020	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	UvrA interaction domain-like	8056687	3002356	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056684	3001550	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	UvrA insert domain-like	8056685	3002355	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056682	3002020	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056682	3002020	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056683	3001550	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056683	3001550	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056682	3002020	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056683	3001550	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	UvrA interaction domain-like	8056687	3002356	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056682	3002020	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056683	3001550	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	UvrA insert domain-like	8056685	3002355	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056684	3001550	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056684	3001550	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056682	3002020	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	UvrA interaction domain-like	8056687	3002356	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056683	3001550	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056683	3001550	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	UvrA insert domain-like	8056685	3002355	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056682	3002020	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	UvrA insert domain-like	8056685	3002355	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056683	3001550	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056681	3002020	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	uvrA_2nd_1	e3zqjA6	A: alpha arrays	X: DNA-binding domain in UvrA (From Topology)	H: DNA-binding domain in UvrA (From Topology)	T: DNA-binding domain in UvrA	F: uvrA_2nd_1	ECOD (1.6)
A	uvrA_1st	e3zqjA5	A: a+b two layers	X: UvrB-binding domain of UvrA (From Topology)	H: UvrB-binding domain of UvrA (From Topology)	T: UvrB-binding domain of UvrA	F: uvrA_1st	ECOD (1.6)
A	ABC_tran	e3zqjA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran	ECOD (1.6)
A	UvrA	e3zqjA3	A: few secondary structure elements	X: DnaJ/Hsp40 cysteine-rich domain (From Topology)	H: DnaJ/Hsp40 cysteine-rich domain (From Topology)	T: DnaJ/Hsp40 cysteine-rich domain	F: UvrA	ECOD (1.6)
B	uvrA_2nd_1	e3zqjB4	A: alpha arrays	X: DNA-binding domain in UvrA (From Topology)	H: DNA-binding domain in UvrA (From Topology)	T: DNA-binding domain in UvrA	F: uvrA_2nd_1	ECOD (1.6)
B	uvrA_1st	e3zqjB3	A: a+b two layers	X: UvrB-binding domain of UvrA (From Topology)	H: UvrB-binding domain of UvrA (From Topology)	T: UvrB-binding domain of UvrA	F: uvrA_1st	ECOD (1.6)
B	ABC_tran	e3zqjB5	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran	ECOD (1.6)
B	UvrA	e3zqjB6	A: few secondary structure elements	X: DnaJ/Hsp40 cysteine-rich domain (From Topology)	H: DnaJ/Hsp40 cysteine-rich domain (From Topology)	T: DnaJ/Hsp40 cysteine-rich domain	F: UvrA	ECOD (1.6)
C	uvrA_2nd_1	e3zqjC3	A: alpha arrays	X: DNA-binding domain in UvrA (From Topology)	H: DNA-binding domain in UvrA (From Topology)	T: DNA-binding domain in UvrA	F: uvrA_2nd_1	ECOD (1.6)
C	uvrA_1st	e3zqjC2	A: a+b two layers	X: UvrB-binding domain of UvrA (From Topology)	H: UvrB-binding domain of UvrA (From Topology)	T: UvrB-binding domain of UvrA	F: uvrA_1st	ECOD (1.6)
C	ABC_tran	e3zqjC4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran	ECOD (1.6)
C	UvrA	e3zqjC6	A: few secondary structure elements	X: DnaJ/Hsp40 cysteine-rich domain (From Topology)	H: DnaJ/Hsp40 cysteine-rich domain (From Topology)	T: DnaJ/Hsp40 cysteine-rich domain	F: UvrA	ECOD (1.6)
D	uvrA_2nd_1	e3zqjD5	A: alpha arrays	X: DNA-binding domain in UvrA (From Topology)	H: DNA-binding domain in UvrA (From Topology)	T: DNA-binding domain in UvrA	F: uvrA_2nd_1	ECOD (1.6)
D	uvrA_1st	e3zqjD4	A: a+b two layers	X: UvrB-binding domain of UvrA (From Topology)	H: UvrB-binding domain of UvrA (From Topology)	T: UvrB-binding domain of UvrA	F: uvrA_1st	ECOD (1.6)
D	ABC_tran	e3zqjD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran	ECOD (1.6)
D	UvrA	e3zqjD6	A: few secondary structure elements	X: DnaJ/Hsp40 cysteine-rich domain (From Topology)	H: DnaJ/Hsp40 cysteine-rich domain (From Topology)	T: DnaJ/Hsp40 cysteine-rich domain	F: UvrA	ECOD (1.6)
E	uvrA_2nd_1	e3zqjE5	A: alpha arrays	X: DNA-binding domain in UvrA (From Topology)	H: DNA-binding domain in UvrA (From Topology)	T: DNA-binding domain in UvrA	F: uvrA_2nd_1	ECOD (1.6)
E	uvrA_1st	e3zqjE6	A: a+b two layers	X: UvrB-binding domain of UvrA (From Topology)	H: UvrB-binding domain of UvrA (From Topology)	T: UvrB-binding domain of UvrA	F: uvrA_1st	ECOD (1.6)
E	ABC_tran	e3zqjE4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran	ECOD (1.6)
E	UvrA	e3zqjE2	A: few secondary structure elements	X: DnaJ/Hsp40 cysteine-rich domain (From Topology)	H: DnaJ/Hsp40 cysteine-rich domain (From Topology)	T: DnaJ/Hsp40 cysteine-rich domain	F: UvrA	ECOD (1.6)
F	uvrA_2nd_1	e3zqjF2	A: alpha arrays	X: DNA-binding domain in UvrA (From Topology)	H: DNA-binding domain in UvrA (From Topology)	T: DNA-binding domain in UvrA	F: uvrA_2nd_1	ECOD (1.6)
F	UvrA,ABC_tran	e3zqjF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: UvrA,ABC_tran	ECOD (1.6)
F	ABC_tran	e3zqjF3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	1.20.1580.10	Mainly Alpha	Up-down Bundle	ABC transporter ATPase like fold	ABC transporter ATPase like domain	CATH (4.3.0)
A	3.30.190.20	Alpha Beta	2-Layer Sandwich	Ribulose 1,5 Bisphosphate Carboxylase/Oxygenase	Ribosomal protein L1/L10, rRNA-binding domain	CATH (4.3.0)
A	1.10.8.280	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	1.20.1580.10	Mainly Alpha	Up-down Bundle	ABC transporter ATPase like fold	ABC transporter ATPase like domain	CATH (4.3.0)
B	3.30.190.20	Alpha Beta	2-Layer Sandwich	Ribulose 1,5 Bisphosphate Carboxylase/Oxygenase	Ribosomal protein L1/L10, rRNA-binding domain	CATH (4.3.0)
B	1.10.8.280	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	1.20.1580.10	Mainly Alpha	Up-down Bundle	ABC transporter ATPase like fold	ABC transporter ATPase like domain	CATH (4.3.0)
C	3.30.190.20	Alpha Beta	2-Layer Sandwich	Ribulose 1,5 Bisphosphate Carboxylase/Oxygenase	Ribosomal protein L1/L10, rRNA-binding domain	CATH (4.3.0)
C	1.10.8.280	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
D	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
D	1.20.1580.10	Mainly Alpha	Up-down Bundle	ABC transporter ATPase like fold	ABC transporter ATPase like domain	CATH (4.3.0)
D	3.30.190.20	Alpha Beta	2-Layer Sandwich	Ribulose 1,5 Bisphosphate Carboxylase/Oxygenase	Ribosomal protein L1/L10, rRNA-binding domain	CATH (4.3.0)
D	1.10.8.280	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
E	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
E	1.20.1580.10	Mainly Alpha	Up-down Bundle	ABC transporter ATPase like fold	ABC transporter ATPase like domain	CATH (4.3.0)
E	3.30.190.20	Alpha Beta	2-Layer Sandwich	Ribulose 1,5 Bisphosphate Carboxylase/Oxygenase	Ribosomal protein L1/L10, rRNA-binding domain	CATH (4.3.0)
E	1.10.8.280	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
F	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
F	1.10.8.280	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF17760	UvrA interaction domain (UvrA_inter)	UvrA interaction domain	This domain found in UvrA proteins interacts with the UvrB protein.	Domain
A, B, C, D, E A, B, C, D, E, F	PF17755	UvrA DNA-binding domain (UvrA_DNA-bind)	UvrA DNA-binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	UVRABC SYSTEM PROTEIN A	excinuclease ABC activity DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity catalytic activity DNA nuclease activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding excinuclease ABC activity DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity catalytic activity DNA nuclease activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides ATP-dependent activity cation binding transition metal ion binding zinc ion binding metal ion binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of DNA recombination negative regulation of biological process regulation of primary metabolic process nucleobase-containing compound metabolic process negative regulation of strand invasion organic substance metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of DNA recombination negative regulation of biological process regulation of primary metabolic process nucleobase-containing compound metabolic process negative regulation of strand invasion organic substance metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of strand invasion negative regulation of macromolecule metabolic process regulation of biological process DNA recombination negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process DNA metabolic process DNA strand invasion nucleic acid metabolic process negative regulation of DNA recombination organic cyclic compound metabolic process metabolic process negative regulation of DNA metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process nucleotide-excision repair DNA repair SOS response	protein-containing complex catalytic complex excinuclease repair complex endodeoxyribonuclease complex intracellular protein-containing complex endonuclease complex DNA repair complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane protein-containing complex catalytic complex excinuclease repair complex endodeoxyribonuclease complex intracellular protein-containing complex endonuclease complex DNA repair complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane external encapsulating structure cell wall peptidoglycan-based cell wall

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR017871	ABC transporter-like, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR003439	ABC transporter-like, ATP-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR041552	UvrA DNA-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR041102	UvrA, interaction domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR004602	UvrABC system subunit A	Family
A, B, C, D, E A, B, C, D, E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily