Annotations: 3X3M

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	EccB1 periplasmic domain-like	8046859	4005331	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	EccB1-like	8103547	3002780	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	T7SS_ESX1_EccB_2nd_1	e3x3mA5	A: a+b two layers	X: ESX-1 secretion system protein eccB1 linker domains (From Topology)	H: ESX-1 secretion system protein eccB1 linker domains (From Topology)	T: ESX-1 secretion system protein eccB1 linker domains	F: T7SS_ESX1_EccB_2nd_1	ECOD (1.6)
A	T7SS_ESX1_EccB_1st	e3x3mA2	A: a+b three layers	X: ESX-1 secretion system protein eccB1 modular domains (From Topology)	H: ESX-1 secretion system protein eccB1 modular domains (From Topology)	T: ESX-1 secretion system protein eccB1 modular domains	F: T7SS_ESX1_EccB_1st	ECOD (1.6)
A	T7SS_ESX1_EccB_2nd	e3x3mA3	A: a+b three layers	X: ESX-1 secretion system protein eccB1 modular domains (From Topology)	H: ESX-1 secretion system protein eccB1 modular domains (From Topology)	T: ESX-1 secretion system protein eccB1 modular domains	F: T7SS_ESX1_EccB_2nd	ECOD (1.6)
A	T7SS_ESX1_EccB_3rd	e3x3mA1	A: a+b three layers	X: ESX-1 secretion system protein eccB1 modular domains (From Topology)	H: ESX-1 secretion system protein eccB1 modular domains (From Topology)	T: ESX-1 secretion system protein eccB1 modular domains	F: T7SS_ESX1_EccB_3rd	ECOD (1.6)
A	T7SS_ESX1_EccB_4th	e3x3mA4	A: a+b three layers	X: ESX-1 secretion system protein eccB1 modular domains (From Topology)	H: ESX-1 secretion system protein eccB1 modular domains (From Topology)	T: ESX-1 secretion system protein eccB1 modular domains	F: T7SS_ESX1_EccB_4th	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.2390.20	Alpha Beta	2-Layer Sandwich	TTHA1013/TTHA0281-like	Type VII secretion system EccB, repeat 1 domain	CATH (4.3.0)
A	2.40.50.910	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Type VII secretion system EccB, repeat 3 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05108	Type VII secretion system ESX-1, transport TM domain B (T7SS_ESX1_EccB)	Type VII secretion system ESX-1, transport TM domain B	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ESX-1 secretion system protein EccB1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding hydrolase activity catalytic activity	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host response to external biotic stimulus modulation of process of another organism	cell periphery plasma membrane membrane cellular anatomical entity external encapsulating structure cell wall peptidoglycan-based cell wall extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR044857	Type VII secretion system EccB, repeat 1 domain	Homologous Superfamily
A	IPR007795	Type VII secretion system EccB	Family
A	IPR042485	Type VII secretion system EccB, repeat 3 domain	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.