3WZT

Crystal structure of Trx3 domain of UGGT (detergent-unbound form)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Thioredoxin-like	8106395	3000031	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thioredoxin-like	8106395	3000031	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thioredoxin-like	8106395	3000031	SCOP2B (2022-06-29)
D	SCOP2 Family	UGGT Trx3 domain-like	8048199	4006009	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Thioredoxin-like	8106395	3000031	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF18403	e3wztA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF18403	ECOD (1.6)
B	PF18403	e3wztB1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF18403	ECOD (1.6)
C	PF18403	e3wztC1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF18403	ECOD (1.6)
D	PF18403	e3wztD1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF18403	ECOD (1.6)
E	PF18403	e3wztE1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF18403	ECOD (1.6)
F	PF18403	e3wztF1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF18403	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF18403	Thioredoxin-like domain (Thioredoxin_15)	Thioredoxin-like domain	This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT)[1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	UDP-glucose-glycoprotein glucosyltransferase-like protein	unfolded protein binding protein binding binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding UDP-glycosyltransferase activity glycosyltransferase activity transferase activity glucosyltransferase activity hexosyltransferase activity catalytic activity unfolded protein binding protein binding binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding UDP-glycosyltransferase activity glycosyltransferase activity transferase activity glucosyltransferase activity hexosyltransferase activity catalytic activity UDP-glucose:glycoprotein glucosyltransferase activity UDP-glucosyltransferase activity cation binding ion binding metal ion binding	cellular biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process protein N-linked glycosylation via asparagine organic substance metabolic process organic substance biosynthetic process protein metabolic process protein modification process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular metabolic process glycoprotein biosynthetic process primary metabolic process glycoprotein metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process protein N-linked glycosylation via asparagine organic substance metabolic process organic substance biosynthetic process protein metabolic process protein modification process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular metabolic process glycoprotein biosynthetic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR040693	UGGT, thioredoxin-like domain 1	Domain
A, B, C, D, E A, B, C, D, E, F	IPR040525	UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4	Domain
A, B, C, D, E A, B, C, D, E, F	IPR040497	Glucosyltransferase 24, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR040694	UGGT, thioredoxin-like domain 2	Domain
A, B, C, D, E A, B, C, D, E, F	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR040692	UGGT, thioredoxin-like domain 3	Domain
A, B, C, D, E A, B, C, D, E, F	IPR009448	UDP-glucose:Glycoprotein Glucosyltransferase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.