3WUU

Structure basis of inactivating cell abscission with chimera peptide 1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	CEP55-EABR coiled coil-like	8104092	3002821	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	CEP55-EABR coiled coil-like	8104092	3002821	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	CEP55-EABR coiled coil-like	8104092	3002821	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	CEP55-EABR coiled coil-like	8104092	3002821	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	CEP55-EABR coiled coil-like	8104092	3002821	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	CEP55-EABR coiled coil-like	8104092	3002821	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	CEP55-EABR coiled coil-like	8104092	3002821	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	CEP55-EABR coiled coil-like	8104092	3002821	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.1180	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Geminin coiled-coil domain	CATH (4.3.0)
E	1.20.5.1180	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Geminin coiled-coil domain	CATH (4.3.0)
G	1.20.5.1180	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Geminin coiled-coil domain	CATH (4.3.0)
B	1.20.5.1180	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Geminin coiled-coil domain	CATH (4.3.0)
D	1.20.5.1180	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Geminin coiled-coil domain	CATH (4.3.0)
H	1.20.5.1180	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Geminin coiled-coil domain	CATH (4.3.0)
J	1.20.5.1180	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Geminin coiled-coil domain	CATH (4.3.0)
K	1.20.5.1180	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Geminin coiled-coil domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, D, E, G A, B, D, E, G, H, J, K	PF12180	TSG101 and ALIX binding domain of CEP55 (EABR)	TSG101 and ALIX binding domain of CEP55	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perf ...	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perform this function, CEP55 complexes with ESCRT-I (by a Proline rich sequence in its TSG101 domain) and ALIX. This is the domain on CEP55 which binds to both TSG101 and ALIX. It also acts as a hinge between the N and C termini. This domain is called EABR.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, D, E, G A, B, D, E, G, H, J, K	Centrosomal protein of 55 kDa	identical protein binding protein binding binding	mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process protein localization localization establishment of protein localization cellular localization cellular macromolecule localization mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process protein localization localization establishment of protein localization cellular localization cellular macromolecule localization macromolecule localization establishment of localization developmental process anatomical structure development cranial skeletal system development membrane organization mitotic cytokinetic process cellular component organization midbody abscission cytokinetic process cellular component organization or biogenesis cellular response to stimulus regulation of biological process regulation of signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cellular process response to stimulus signaling biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction	midbody cellular anatomical entity intercellular bridge membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle centriole midbody cellular anatomical entity intercellular bridge membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle centriole Flemming body cytoplasm cell division site cell periphery cleavage furrow plasma membrane plasma membrane region
C, F, I, L	TEX-14	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding kinase binding enzyme binding protein kinase binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups	regulation of cytokinesis regulation of biological process regulation of cellular process negative regulation of cytokinesis regulation of cell cycle process biological regulation negative regulation of biological process negative regulation of cell cycle cytokinesis negative regulation of cell cycle process regulation of cell division negative regulation of cell division negative regulation of cellular process cellular process regulation of cytokinesis regulation of biological process regulation of cellular process negative regulation of cytokinesis regulation of cell cycle process biological regulation negative regulation of biological process negative regulation of cell cycle cytokinesis negative regulation of cell cycle process regulation of cell division negative regulation of cell division negative regulation of cellular process cellular process cell cycle cell division regulation of cell cycle cell cycle process mitotic nuclear division organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome separation mitotic sister chromatid segregation nuclear chromosome segregation mitotic sister chromatid separation cellular component organization or biogenesis chromosome segregation establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell establishment of chromosome localization cellular response to stimulus regulation of cell cycle phase transition response to stimulus spindle checkpoint signaling regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle signaling spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition regulation of mitotic cell cycle negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation negative regulation of mitotic cell cycle phase transition cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling negative regulation of chromosome segregation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition intercellular bridge organization extracellular structure organization sexual reproduction reproductive process meiotic cell cycle male meiotic nuclear division multicellular organismal reproductive process meiotic cell cycle process male gamete generation gamete generation meiotic nuclear division response to organic substance response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance	midbody cellular anatomical entity intercellular bridge intracellular anatomical structure chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome midbody cellular anatomical entity intercellular bridge intracellular anatomical structure chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, D, E, G A, B, D, E, G, H, J, K	IPR022008	TSG101 and ALIX binding domain of CEP55	Domain
A, B, D, E, G A, B, D, E, G, H, J, K	IPR038926	Centrosomal protein of 55kDa	Family
C, F, I, L	IPR002110	Ankyrin repeat	Repeat
C, F, I, L	IPR039339	Inactive serine/threonine-protein kinase TEX14	Family
C, F, I, L	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
C, F, I, L	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
C, F, I, L	IPR000719	Protein kinase domain	Domain
C, F, I, L	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, D, E, G A, B, D, E, G, H, J, K	Pharos: Q53EZ4	polycystic ovary syndrome multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome malignant glioma medulloblastoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm adrenal cortex carcinoma primitive neuroectodermal tumor breast cancer Sjogren syndrome Crohn disease esophageal adenocarcinoma IgA glomerulonephritis large cell medulloblastoma malignant colon neoplasm polycystic ovary syndrome multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome malignant glioma medulloblastoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm adrenal cortex carcinoma primitive neuroectodermal tumor breast cancer Sjogren syndrome Crohn disease esophageal adenocarcinoma IgA glomerulonephritis large cell medulloblastoma malignant colon neoplasm malignant pancreatic neoplasm ovarian cancer pilocytic astrocytoma atopic eczema psoriasis breast carcinoma ulcerative colitis ductal breast carcinoma in situ glioblastoma interstitial cystitis lung adenocarcinoma malignant ependymoma Meckel syndrome nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous carcinoma atypical teratoid rhabdoid tumor Sclerocystic Ovaries endometriosis hepatocellular carcinoma invasive ductal breast carcinoma lung cancer
C, F, I, L	Pharos: Q8IWB6	gastric adenocarcinoma medulloblastoma spermatogenic failure 23 tuberculosis lung cancer non-small cell lung carcinoma testicular cancer malignant mesothelioma osteosarcoma testicular germ cell tumor

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.