3WOZ

Crystal structure of CLASP2 TOG domain (TOG3)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF21040	e3wozB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF21040	ECOD (1.6)
C	PF21040	e3wozC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF21040	ECOD (1.6)
D	PF21040	e3wozD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF21040	ECOD (1.6)
A	PF21040	e3wozA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF21040	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
C	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
D	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF21040	Centrosomal protein CEP104-like, TOG domain (CEP104-like_TOG)	Centrosomal protein CEP104-like, TOG domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	CLIP-associating protein 2	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding microtubule binding tubulin binding microtubule plus-end binding protein tyrosine kinase binding kinase binding enzyme binding protein kinase binding dystroglycan binding	cellular process cell division negative regulation of locomotion regulation of cell motility regulation of cellular process response to stimulus regulation of response to external stimulus negative regulation of biological process negative regulation of wound healing, spreading of epidermal cells regulation of response to wounding response to stress regulation of response to stress regulation of cell migration anatomical structure development cellular process cell division negative regulation of locomotion regulation of cell motility regulation of cellular process response to stimulus regulation of response to external stimulus negative regulation of biological process negative regulation of wound healing, spreading of epidermal cells regulation of response to wounding response to stress regulation of response to stress regulation of cell migration anatomical structure development negative regulation of cellular process cell migration response to wounding cell motility regulation of wound healing, spreading of epidermal cells locomotion negative regulation of cell migration developmental process wound healing regulation of biological process epithelium development negative regulation of response to stimulus negative regulation of wound healing biological regulation morphogenesis of an epithelium response to external stimulus negative regulation of response to wounding epiboly involved in wound healing tissue development morphogenesis of an epithelial sheet wound healing, spreading of epidermal cells tissue morphogenesis anatomical structure morphogenesis regulation of response to stimulus negative regulation of response to external stimulus regulation of locomotion regulation of wound healing epiboly negative regulation of cell motility wound healing, spreading of cells cellular response to stimulus platelet-derived growth factor receptor-beta signaling pathway cell surface receptor signaling pathway signaling platelet-derived growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway establishment of organelle localization cellular localization microtubule cytoskeleton organization spindle localization establishment of localization mitotic cell cycle cellular component organization localization establishment of mitotic spindle localization organelle organization mitotic cell cycle process establishment of spindle localization organelle localization establishment of localization in cell microtubule-based process cell cycle cellular component organization or biogenesis microtubule cytoskeleton organization involved in mitosis cytoskeleton organization cell cycle process protein localization protein localization to cell periphery protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane ameboidal-type cell migration fibroblast migration cellular component disassembly protein-containing complex organization protein-containing complex disassembly microtubule polymerization or depolymerization microtubule depolymerization supramolecular fiber organization protein depolymerization establishment of cell polarity establishment or maintenance of cell polarity microtubule anchoring regulation of localization regulation of protein localization positive regulation of biological process positive regulation of protein localization to membrane regulation of cellular localization positive regulation of protein localization regulation of protein localization to membrane positive regulation of cellular process multicellular organismal process regulation of embryonic development regulation of multicellular organismal development regulation of gastrulation regulation of developmental process embryonic morphogenesis embryo development gastrulation multicellular organism development regulation of multicellular organismal process regulation of anatomical structure morphogenesis microtubule organizing center organization protein polymerization microtubule polymerization cellular component biogenesis cellular component assembly microtubule nucleation protein-containing complex assembly extracellular matrix disassembly regulation of cellular component organization positive regulation of cellular component organization positive regulation of extracellular matrix organization extracellular matrix organization positive regulation of extracellular matrix disassembly regulation of extracellular matrix organization regulation of extracellular matrix disassembly extracellular structure organization external encapsulating structure organization cell-substrate junction assembly negative regulation of cell-substrate junction organization negative regulation of cell-matrix adhesion negative regulation of cell adhesion cell adhesion negative regulation of cell junction assembly cell junction assembly regulation of cell-substrate junction organization focal adhesion assembly negative regulation of cellular component organization regulation of cell-substrate adhesion regulation of cell adhesion cell-substrate adhesion regulation of cellular component biogenesis negative regulation of focal adhesion assembly regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization negative regulation of cell-substrate adhesion regulation of focal adhesion assembly regulation of cell-substrate junction assembly regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly actin filament bundle organization actin filament-based process stress fiber assembly negative regulation of supramolecular fiber organization regulation of actin filament organization negative regulation of stress fiber assembly actin cytoskeleton organization actomyosin structure organization negative regulation of cytoskeleton organization actin filament organization negative regulation of actin filament bundle assembly regulation of organelle organization regulation of stress fiber assembly negative regulation of organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization transport positive regulation of secretion by cell positive regulation of exocytosis vesicle-mediated transport regulation of secretion by cell secretion by cell positive regulation of secretion regulation of transport secretion export from cell regulation of vesicle-mediated transport regulation of secretion positive regulation of transport exocytosis regulation of exocytosis regulation of epithelial to mesenchymal transition cellular developmental process animal organ development regulation of cell differentiation mesenchyme development epithelial to mesenchymal transition cell differentiation mesenchymal cell differentiation mitotic nuclear division organelle fission cell cycle phase transition exit from mitosis nuclear division mitotic cell cycle phase transition axon extension regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization neuron projection development cell projection morphogenesis neuron differentiation neuron projection morphogenesis regulation of biological quality system development nervous system development developmental growth involved in morphogenesis generation of neurons plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension neurogenesis regulation of extent of cell growth regulation of cell size neuron projection extension regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation neuron development regulation of anatomical structure size regulation of microtubule polymerization or depolymerization regulation of protein-containing complex assembly regulation of microtubule-based process regulation of microtubule polymerization regulation of protein polymerization regulation of microtubule cytoskeleton organization basement membrane assembly involved in embryonic body morphogenesis cellular component assembly involved in morphogenesis body morphogenesis positive regulation of developmental process cellular anatomical entity morphogenesis regulation of extracellular matrix assembly regulation of basement membrane organization extracellular matrix assembly basement membrane organization positive regulation of basement membrane assembly involved in embryonic body morphogenesis positive regulation of cellular component biogenesis regulation of basement membrane assembly involved in embryonic body morphogenesis embryonic body morphogenesis positive regulation of extracellular matrix assembly basement membrane assembly anatomical structure formation involved in morphogenesis non-membrane-bounded organelle assembly mitotic sister chromatid segregation chromosome segregation spindle organization organelle assembly chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly nuclear chromosome segregation sexual reproduction reproductive process meiotic cell cycle vesicle localization establishment of vesicle localization vesicle targeting negative regulation of microtubule depolymerization regulation of protein-containing complex disassembly regulation of microtubule depolymerization negative regulation of protein-containing complex disassembly negative regulation of microtubule polymerization or depolymerization regulation of protein depolymerization negative regulation of protein depolymerization Golgi organization endomembrane system organization positive regulation of locomotion positive regulation of cell migration positive regulation of epithelial cell migration tissue migration positive regulation of cell motility epithelial cell migration regulation of epithelial cell migration epithelium migration	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol cell leading edge membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol cell leading edge membrane-bounded organelle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system trans-Golgi network polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex growth cone axon cell projection distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth cell periphery cell cortex basal part of cell cell cortex region cytoplasmic region basal cortex ruffle plasma membrane membrane leading edge membrane ruffle membrane plasma membrane region cell projection membrane centrosome microtubule organizing center mitotic spindle chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome cortical microtubule plus-end cytoplasmic microtubule microtubule plus-end cytoplasmic microtubule plus-end microtubule end cortical cytoskeleton cortical microtubule cortical microtubule cytoskeleton spindle microtubule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B, C, D	IPR034085	TOG domain	Domain
A, B, C, D	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B, C, D	IPR024395	CLASP N-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.