3WO3
Crystal structure of IL-18 in complex with IL-18 receptor alpha
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | d3wo3c_ | All beta proteins | beta-Trefoil | Cytokine | Interleukin-1 (IL-1) | Interleukin-18 | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
E | d3wo3e_ | All beta proteins | beta-Trefoil | Cytokine | Interleukin-1 (IL-1) | Interleukin-18 | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
G | d3wo3g_ | All beta proteins | beta-Trefoil | Cytokine | Interleukin-1 (IL-1) | Interleukin-18 | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
I | d3wo3i_ | All beta proteins | beta-Trefoil | Cytokine | Interleukin-1 (IL-1) | Interleukin-18 | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
K | d3wo3k_ | All beta proteins | beta-Trefoil | Cytokine | Interleukin-1 (IL-1) | Interleukin-18 | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d3wo3a_ | All beta proteins | beta-Trefoil | Cytokine | Interleukin-1 (IL-1) | Interleukin-18 | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
C | SCOP2B Superfamily | Cytokine | 8036000 | 3000648 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Cytokine | 8036000 | 3000648 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | Cytokine | 8036000 | 3000648 | SCOP2B (2022-06-29) |
I | SCOP2B Superfamily | Cytokine | 8036000 | 3000648 | SCOP2B (2022-06-29) |
K | SCOP2B Superfamily | Cytokine | 8036000 | 3000648 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Cytokine | 8036000 | 3000648 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | PF00340 | e3wo3C1 | A: beta duplicates or obligate multimers | X: beta-Trefoil (From Topology) | H: beta-Trefoil (From Topology) | T: beta-Trefoil | F: PF00340 | ECOD (1.6) |
E | PF00340 | e3wo3E1 | A: beta duplicates or obligate multimers | X: beta-Trefoil (From Topology) | H: beta-Trefoil (From Topology) | T: beta-Trefoil | F: PF00340 | ECOD (1.6) |
G | PF00340 | e3wo3G1 | A: beta duplicates or obligate multimers | X: beta-Trefoil (From Topology) | H: beta-Trefoil (From Topology) | T: beta-Trefoil | F: PF00340 | ECOD (1.6) |
I | PF00340 | e3wo3I1 | A: beta duplicates or obligate multimers | X: beta-Trefoil (From Topology) | H: beta-Trefoil (From Topology) | T: beta-Trefoil | F: PF00340 | ECOD (1.6) |
K | PF00340 | e3wo3K1 | A: beta duplicates or obligate multimers | X: beta-Trefoil (From Topology) | H: beta-Trefoil (From Topology) | T: beta-Trefoil | F: PF00340 | ECOD (1.6) |
A | PF00340 | e3wo3A1 | A: beta duplicates or obligate multimers | X: beta-Trefoil (From Topology) | H: beta-Trefoil (From Topology) | T: beta-Trefoil | F: PF00340 | ECOD (1.6) |
D | F_UNCLASSIFIED | e3wo3D1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
D | PF13895 | e3wo3D3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF13895 | ECOD (1.6) |
F | F_UNCLASSIFIED | e3wo3F1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
F | PF13895 | e3wo3F3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF13895 | ECOD (1.6) |
H | F_UNCLASSIFIED | e3wo3H1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
H | PF13895 | e3wo3H3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF13895 | ECOD (1.6) |
J | F_UNCLASSIFIED | e3wo3J1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
J | PF13895 | e3wo3J3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF13895 | ECOD (1.6) |
L | F_UNCLASSIFIED | e3wo3L1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
L | PF13895 | e3wo3L3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF13895 | ECOD (1.6) |
B | F_UNCLASSIFIED | e3wo3B1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
B | PF13895 | e3wo3B3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF13895 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
IL18 binding protein | IL-18 | Homo sapiens (human) | IL18*01 | R-LIKE-DOMAIN IL18 (Pr37-193) | RPI | (IL-18) | IMGT (202416-0) | |
IL18R1 (Interleukin-18 receptor 1) | 3C-LIKE | Homo sapiens (human) | IL18R1*01 | C-LIKE-DOMAIN C-LIKE | RPI | 3C-LIKE | IMGT (202416-0) |
Protein Family Annotation Pfam Database Homepage
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR000975 | Interleukin-1 family | Family | |
IPR015529 | Interleukin-18 | Family | |
IPR008996 | Cytokine IL1/FGF | Homologous Superfamily | |
IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain | Domain | |
IPR004074 | Interleukin-1 receptor type I/II | Family | |
IPR036179 | Immunoglobulin-like domain superfamily | Homologous Superfamily | |
IPR003599 | Immunoglobulin subtype | Domain | |
IPR015621 | Interleukin-1 receptor family | Family | |
IPR013783 | Immunoglobulin-like fold | Homologous Superfamily | |
IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily | Homologous Superfamily | |
IPR007110 | Immunoglobulin-like domain | Domain |