Annotations: 3W3Y

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13513,PF18808,PF18816,PF18829	e3w3yA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF13513,PF18808,PF18816,PF18829	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.140.1700	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF18808	Importin repeat (Importin_rep_4)	Importin repeat	-	Repeat
A	PF18816	Importin repeat (Importin_rep_5)	Importin repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Importin subunit beta-3	nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity nuclear localization sequence binding signal sequence binding binding peptide binding	regulation of protein modification process peptidyl-lysine modification protein desumoylation regulation of primary metabolic process organic substance metabolic process protein modification by small protein removal peptidyl-amino acid modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process regulation of biological process organonitrogen compound metabolic process regulation of post-translational protein modification regulation of protein metabolic process regulation of protein modification process peptidyl-lysine modification protein desumoylation regulation of primary metabolic process organic substance metabolic process protein modification by small protein removal peptidyl-amino acid modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process regulation of biological process organonitrogen compound metabolic process regulation of post-translational protein modification regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation or removal regulation of protein desumoylation mitotic nuclear division regulation of cellular component organization regulation of cellular process regulation of cell cycle process organelle fission regulation of mitotic nuclear division regulation of organelle organization mitotic cell cycle cellular component organization regulation of mitotic cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division cellular process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process cellular localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport cellular metabolic process nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	Nucleoporin NUP53	binding phospholipid binding lipid binding structural molecule activity structural constituent of nuclear pore identical protein binding protein binding DNA binding organic cyclic compound binding single-stranded DNA binding nucleic acid binding	cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis regulation of protein modification process peptidyl-lysine modification protein desumoylation regulation of primary metabolic process organic substance metabolic process protein modification by small protein removal peptidyl-amino acid modification cellular component organization nucleus organization organelle organization nuclear pore organization protein-containing complex organization cellular process cellular component organization or biogenesis regulation of protein modification process peptidyl-lysine modification protein desumoylation regulation of primary metabolic process organic substance metabolic process protein modification by small protein removal peptidyl-amino acid modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process regulation of biological process organonitrogen compound metabolic process regulation of post-translational protein modification regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation or removal regulation of protein desumoylation RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport protein localization cellular localization protein localization to chromosome, centromeric region protein localization to kinetochore protein localization to chromosome protein localization to condensed chromosome protein localization to organelle cellular macromolecule localization cell division nucleocytoplasmic transport nuclear transport establishment of localization in cell intracellular transport establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport protein import into nucleus intracellular protein transport cell cycle NLS-bearing protein import into nucleus mitotic nuclear division regulation of cellular component organization regulation of cellular process regulation of cell cycle process organelle fission regulation of mitotic nuclear division regulation of organelle organization mitotic cell cycle regulation of mitotic cell cycle nuclear division mitotic cell cycle process regulation of nuclear division regulation of cell cycle cell cycle process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular response to biotic stimulus cellular response to stimulus cellular response to endogenous stimulus response to stimulus response to endogenous stimulus response to cell cycle checkpoint signaling response to spindle checkpoint signaling response to biotic stimulus	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane protein-containing complex nuclear protein-containing complex nuclear pore nuclear pore central transport channel nuclear pore nuclear basket

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR040122	Importin beta family	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR041389	Importin repeat 6	Repeat
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR041653	Importin repeat 4	Repeat
A	IPR040928	Importin repeat	Repeat
B	IPR007846	RNA-recognition motif (RRM) Nup35-type domain	Domain
B	IPR017389	Nucleoporin, NUP53	Family
B	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
B	IPR035979	RNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.