Annotations: 3VX7

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Atg7 N-terminal domain-like	8045562	4004534	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	JAB1/MPN domain-like	8052659	3001105	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	JAB1/MPN domain-like	8052660	3001105	SCOP2 (2022-06-29)
B	SCOP2 Family	Atg3-like	8045327	4004412	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Type III secretory system chaperone-like	8052661	3000727	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ATG7_N_1st	e3vx7A1	A: a/b three-layered sandwiches	X: Atg7 N-terminal domain-like	H: N-terminal domain in E1 enzyme Atg7 (From Topology)	T: N-terminal domain in E1 enzyme Atg7	F: ATG7_N_1st	ECOD (1.6)
A	EUF08640	e3vx7A2	A: a/b three-layered sandwiches	X: Atg7 N-terminal domain-like	H: N-terminal domain in E1 enzyme Atg7 (From Topology)	T: N-terminal domain in E1 enzyme Atg7	F: EUF08640	ECOD (1.6)
B	Autophagy_act_C_1	e3vx7B1	A: a+b two layers	X: Type III secretory system chaperone-like	H: Type III secretory system chaperone (From Topology)	T: Type III secretory system chaperone	F: Autophagy_act_C_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.1460.50	Alpha Beta	2-Layer Sandwich	Yope Regulator	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16420	Ubiquitin-like modifier-activating enzyme ATG7 N-terminus (ATG7_N)	Ubiquitin-like modifier-activating enzyme ATG7 N-terminus	This is the N-terminal domain of Ubiquitin-like modifier-activating enzyme ATG7. In Arabidopsis this domain binds the E2 enzymes ATG10 and ATG3 [1].	Domain
B	PF03987	Autophagocytosis associated protein, active-site domain (Autophagy_act_C)	Autophagocytosis associated protein, active-site domain	Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole. The cysteine residue within the HPC motif is the putative active-site residue for recognition of the Apg5 subunit of the autophagosome ...	Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole. The cysteine residue within the HPC motif is the putative active-site residue for recognition of the Apg5 subunit of the autophagosome complex [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	E1	-	-	-
B	E2	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity	cellular catabolic process catabolic process cellular metabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization cellular catabolic process catabolic process cellular metabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization	phagophore assembly site membrane intracellular anatomical structure membrane phagophore assembly site cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR042522	Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1	Homologous Superfamily
A	IPR032197	Ubiquitin-like modifier-activating enzyme Atg7, N-terminal	Domain
A	IPR042523	Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2	Homologous Superfamily
B	IPR007135	Ubiquitin-like-conjugating enzyme Atg3/Atg10	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.