3VRQ

Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3vrqa1	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3vrqa3	All alpha proteins	N-cbl like	N-terminal domain of cbl (N-cbl)	N-terminal domain of cbl (N-cbl)	N-terminal domain of cbl (N-cbl)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3vrqa2	Alpha and beta proteins (a+b)	SH2-like	SH2 domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3vrqb1	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3vrqb3	All alpha proteins	N-cbl like	N-terminal domain of cbl (N-cbl)	N-terminal domain of cbl (N-cbl)	N-terminal domain of cbl (N-cbl)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3vrqb2	Alpha and beta proteins (a+b)	SH2-like	SH2 domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02761	e3vrqA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF02761	ECOD (1.6)
A	PF02262	e3vrqA2	A: alpha bundles	X: N-cbl like	H: N-terminal domain of cbl (N-cbl) (From Topology)	T: N-terminal domain of cbl (N-cbl)	F: PF02262	ECOD (1.6)
A	PF02762	e3vrqA3	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: PF02762	ECOD (1.6)
B	PF02761	e3vrqB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF02761	ECOD (1.6)
B	PF02262	e3vrqB2	A: alpha bundles	X: N-cbl like	H: N-terminal domain of cbl (N-cbl) (From Topology)	T: N-terminal domain of cbl (N-cbl)	F: PF02262	ECOD (1.6)
B	PF02762	e3vrqB3	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: PF02762	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.930.20	Mainly Alpha	Up-down Bundle	Transcription Elongation Factor S-II	Chain A	CATH (4.3.0)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
B	1.20.930.20	Mainly Alpha	Up-down Bundle	Transcription Elongation Factor S-II	Chain A	CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02262	CBL proto-oncogene N-terminal domain 1 (Cbl_N)	CBL proto-oncogene N-terminal domain 1	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.	Domain
A, B	PF02762	CBL proto-oncogene N-terminus, SH2-like domain (Cbl_N3)	CBL proto-oncogene N-terminus, SH2-like domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.	Domain
A, B	PF02761	CBL proto-oncogene N-terminus, EF hand-like domain (Cbl_N2)	CBL proto-oncogene N-terminus, EF hand-like domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Signal transduction protein CBL-C	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoprotein binding phosphotyrosine residue binding protein binding protein phosphorylated amino acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoprotein binding phosphotyrosine residue binding protein binding protein phosphorylated amino acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity SH3 domain binding protein domain specific binding epidermal growth factor receptor binding signaling receptor binding growth factor receptor binding protein tyrosine kinase binding kinase binding receptor tyrosine kinase binding enzyme binding protein kinase binding transition metal ion binding zinc ion binding	cellular response to stimulus regulation of cellular process response to stimulus negative regulation of protein tyrosine kinase activity regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity negative regulation of cellular metabolic process cell surface receptor protein tyrosine kinase signaling pathway regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity cellular response to stimulus regulation of cellular process response to stimulus negative regulation of protein tyrosine kinase activity regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity negative regulation of cellular metabolic process cell surface receptor protein tyrosine kinase signaling pathway regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process negative regulation of protein modification process epidermal growth factor receptor signaling pathway signal transduction protein modification process phosphorus metabolic process negative regulation of protein metabolic process regulation of biological process regulation of ERBB signaling pathway protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of molecular function regulation of protein tyrosine kinase activity regulation of kinase activity regulation of response to stimulus negative regulation of protein phosphorylation negative regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway macromolecule modification metabolic process regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation signaling negative regulation of signaling regulation of epidermal growth factor-activated receptor activity regulation of signaling receptor activity negative regulation of ERBB signaling pathway negative regulation of phosphate metabolic process peptidyl-tyrosine modification negative regulation of cell communication organic substance metabolic process regulation of epidermal growth factor receptor signaling pathway negative regulation of cellular process protein metabolic process enzyme-linked receptor protein signaling pathway negative regulation of macromolecule metabolic process negative regulation of peptidyl-tyrosine phosphorylation regulation of signaling organonitrogen compound metabolic process cell surface receptor signaling pathway negative regulation of response to stimulus regulation of peptidyl-tyrosine phosphorylation biological regulation negative regulation of molecular function regulation of macromolecule metabolic process regulation of protein kinase activity negative regulation of protein kinase activity negative regulation of epidermal growth factor-activated receptor activity negative regulation of signal transduction negative regulation of phosphorus metabolic process regulation of cell communication cellular process regulation of phosphorylation negative regulation of phosphorylation peptidyl-tyrosine phosphorylation negative regulation of signaling receptor activity regulation of MAP kinase activity intracellular signal transduction intracellular signaling cassette regulation of MAPK cascade regulation of protein serine/threonine kinase activity negative regulation of intracellular signal transduction regulation of intracellular signal transduction negative regulation of protein serine/threonine kinase activity negative regulation of MAP kinase activity MAPK cascade negative regulation of MAPK cascade protein ubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process	cell periphery plasma membrane membrane cellular anatomical entity membrane microdomain membrane raft

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, B	IPR024159	Adaptor protein Cbl, PTB domain	Domain
A, B	IPR003153	Adaptor protein Cbl, N-terminal helical	Domain
A, B	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
A, B	IPR024162	Adaptor protein Cbl	Family
A, B	IPR014741	Adaptor protein Cbl, EF hand-like	Domain
A, B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B	IPR014742	Adaptor protein Cbl, SH2-like domain	Domain
A, B	IPR036537	Adaptor protein Cbl, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR001841	Zinc finger, RING-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9ULV8	acute myeloid leukemia Cytopenia malignant pancreatic neoplasm ulcerative colitis central nervous system disease interstitial cystitis metabolic syndrome X congenital anemia lung adenocarcinoma non-small cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.