3V94

TcrPDEC1 catalytic domain in complex with inhibitor wyq16

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E	d3v94e_	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
G	d3v94g_	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
A	d3v94a_	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
B	d3v94b_	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
C	d3v94c_	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
D	d3v94d_	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
F	d3v94f_	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
H	d3v94h_	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E	SCOP2B Superfamily	HD-domain/PDEase-like	8067473	3000943	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	HD-domain/PDEase-like	8067473	3000943	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	HD-domain/PDEase-like	8067473	3000943	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HD-domain/PDEase-like	8067473	3000943	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	HD-domain/PDEase-like	8067473	3000943	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HD-domain/PDEase-like	8067473	3000943	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	HD-domain/PDEase-like	8067473	3000943	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	HD-domain/PDEase-like	8067473	3000943	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	PF00233	e3v94E1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF00233	ECOD (1.6)
G	PF00233	e3v94G1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF00233	ECOD (1.6)
A	PF00233	e3v94A1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF00233	ECOD (1.6)
B	PF00233	e3v94B1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF00233	ECOD (1.6)
C	PF00233	e3v94C1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF00233	ECOD (1.6)
D	PF00233	e3v94D1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF00233	ECOD (1.6)
F	PF00233	e3v94F1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF00233	ECOD (1.6)
H	PF00233	e3v94H1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF00233	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E	1.10.1300.10	Mainly Alpha	Orthogonal Bundle	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	CATH (4.3.0)
G	1.10.1300.10	Mainly Alpha	Orthogonal Bundle	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	CATH (4.3.0)
A	1.10.1300.10	Mainly Alpha	Orthogonal Bundle	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	CATH (4.3.0)
B	1.10.1300.10	Mainly Alpha	Orthogonal Bundle	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	CATH (4.3.0)
C	1.10.1300.10	Mainly Alpha	Orthogonal Bundle	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	CATH (4.3.0)
D	1.10.1300.10	Mainly Alpha	Orthogonal Bundle	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	CATH (4.3.0)
F	1.10.1300.10	Mainly Alpha	Orthogonal Bundle	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	CATH (4.3.0)
H	1.10.1300.10	Mainly Alpha	Orthogonal Bundle	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00233	3'5'-cyclic nucleotide phosphodiesterase (PDEase_I)	3'5'-cyclic nucleotide phosphodiesterase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Cyclic nucleotide specific phosphodiesterase	cation binding ion binding binding metal ion binding small molecule binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity cyclic-nucleotide phosphodiesterase activity catalytic activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular process signal transduction cell communication	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000306	FYVE zinc finger	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR003607	HD/PDEase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR017455	Zinc finger, FYVE-related	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR023088	3'5'-cyclic nucleotide phosphodiesterase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.