3V8O

Human Filamin C Ig - like Domains 4 and 5

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3v8oa1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3v8oa3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3v8ob1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Filamin	e3v8oA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Filamin	ECOD (1.6)
B	Filamin	e3v8oB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Filamin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00630	Filamin/ABP280 repeat (Filamin)	Filamin/ABP280 repeat	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Filamin-C	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding ankyrin binding identical protein binding	cellular developmental process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development muscle cell differentiation cellular component organization cellular component biogenesis muscle structure development striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation sarcomere organization anatomical structure development cellular developmental process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development muscle cell differentiation cellular component organization cellular component biogenesis muscle structure development striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation sarcomere organization anatomical structure development actin filament-based process cellular component organization or biogenesis developmental process actomyosin structure organization actin cytoskeleton organization organelle assembly anatomical structure morphogenesis myofibril assembly organelle organization anatomical structure formation involved in morphogenesis cellular process striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction intercellular bridge intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction intercellular bridge intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cytoskeleton cytosol cell periphery sarcolemma plasma membrane membrane costamere

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR044801	Filamin family	Family
A, B	IPR001589	Actinin-type actin-binding domain, conserved site	Conserved Site
A, B	IPR017868	Filamin/ABP280 repeat-like	Repeat
A, B	IPR036872	CH domain superfamily	Homologous Superfamily
A, B	IPR001715	Calponin homology domain	Domain
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, B	IPR001298	Filamin/ABP280 repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q14315	myofibrillar myopathy 5 myopathy hypertrophic cardiomyopathy 26 distal myopathy with posterior leg and anterior hand involvement cardiomyopathy dilated cardiomyopathy distal myopathy colorectal cancer invasive ductal breast carcinoma malignant ependymoma muscle tissue disease Other restrictive cardiomyopathy allergic bronchopulmonary aspergillosis primary biliary cholangitis rheumatoid arthritis myofibrillar myopathy 5 myopathy hypertrophic cardiomyopathy 26 distal myopathy with posterior leg and anterior hand involvement cardiomyopathy dilated cardiomyopathy distal myopathy colorectal cancer invasive ductal breast carcinoma malignant ependymoma muscle tissue disease Other restrictive cardiomyopathy allergic bronchopulmonary aspergillosis primary biliary cholangitis rheumatoid arthritis colorectal carcinoma systemic sclerosis hypertrophic cardiomyopathy limb-girdle muscular dystrophy malignant glioma muscular disease ovarian cancer arthrogryposis psoriasis Sjogren syndrome ulcerative colitis congestive heart failure glioblastoma malignant colon neoplasm medulloblastoma myofibrillar myopathy myositis pilocytic astrocytoma atrial fibrillation restrictive cardiomyopathy systemic lupus erythematosus cystic fibrosis Hodgkins lymphoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.