3V47

Crystal structure of the N-terminal fragment of zebrafish TLR5 in complex with Salmonella flagellin

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF11921,PF13855	e3v47A3	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF11921,PF13855	ECOD (1.6)
B	PF11921,PF13855	e3v47B3	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF11921,PF13855	ECOD (1.6)
C	PF22370	e3v47C2	A: beta complex topology	X: Flagellin beta sheet domain (From Topology)	H: Flagellin beta sheet domain (From Topology)	T: Flagellin beta sheet domain	F: PF22370	ECOD (1.6)
C	PF00669,PF00700	e3v47C1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-helical domain in phase 1 flagellin (From Topology)	T: alpha-helical domain in phase 1 flagellin	F: PF00669,PF00700	ECOD (1.6)
D	PF22370	e3v47D1	A: beta complex topology	X: Flagellin beta sheet domain (From Topology)	H: Flagellin beta sheet domain (From Topology)	T: Flagellin beta sheet domain	F: PF22370	ECOD (1.6)
D	PF00669,PF00700	e3v47D2	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-helical domain in phase 1 flagellin (From Topology)	T: alpha-helical domain in phase 1 flagellin	F: PF00669,PF00700	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.20.1330.10	Mainly Alpha	Up-down Bundle	f41 fragment of flagellin, N-terminal domain	f41 fragment of flagellin, N-terminal domain	CATH (4.3.0)
D	1.20.1330.10	Mainly Alpha	Up-down Bundle	f41 fragment of flagellin, N-terminal domain	f41 fragment of flagellin, N-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
A, B	PF11921	Domain of unknown function (DUF3439) (DUF3439)	Domain of unknown function (DUF3439)	-	Family
C, D	PF00700	Bacterial flagellin C-terminal helical region (Flagellin_C)	Bacterial flagellin C-terminal helical region	-	Family
C, D	PF00669	Bacterial flagellin N-terminal helical region (Flagellin_N)	Bacterial flagellin N-terminal helical region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Toll-like receptor 5b and variable lymphocyte receptor B.61 chimeric protein	molecular transducer activity signaling receptor activity transmembrane signaling receptor activity	cellular response to stimulus positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus pattern recognition receptor signaling pathway response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process cell surface toll-like receptor signaling pathway cellular response to stimulus positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus pattern recognition receptor signaling pathway response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process cell surface toll-like receptor signaling pathway innate immune response-activating signaling pathway regulation of biological process immune response response to other organism immune response-activating cell surface receptor signaling pathway regulation of innate immune response response to external stimulus regulation of response to stimulus defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response toll-like receptor 5 signaling pathway activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus signaling positive regulation of biological process innate immune response activating cell surface receptor signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response response to external biotic stimulus cell surface pattern recognition receptor signaling pathway positive regulation of innate immune response cell surface receptor signaling pathway defense response biological regulation defense response to symbiont immune system process cellular process inflammatory response toll-like receptor signaling pathway	membrane cellular anatomical entity
C, D	Flagellin	structural molecule activity	-	cell projection organelle cellular anatomical entity bacterial-type flagellum non-membrane-bounded organelle extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B	IPR000372	Leucine-rich repeat N-terminal domain	Domain
A, B	IPR024592	Variable lymphocyte receptor, C-terminal	Domain
A, B	IPR001611	Leucine-rich repeat	Repeat
A, B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, B	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A, B	IPR001611	Leucine-rich repeat	Repeat
A, B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, B	IPR017241	Toll-like receptor	Family
A, B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A, B	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
C, D	IPR046358	Flagellin, C-terminal domain	Domain
C, D	IPR001029	Flagellin, N-terminal domain	Domain
C, D	IPR042187	Flagellin, C-terminal domain, subdomain 2	Homologous Superfamily
C, D	IPR001492	Flagellin	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.