Annotations: 3V2Q

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3v2qb_	Coiled coil proteins	Parallel coiled-coil	Assembly domain of cartilage oligomeric matrix protein	Assembly domain of cartilage oligomeric matrix protein	Assembly domain of cartilage oligomeric matrix protein	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d3v2qc_	Coiled coil proteins	Parallel coiled-coil	Assembly domain of cartilage oligomeric matrix protein	Assembly domain of cartilage oligomeric matrix protein	Assembly domain of cartilage oligomeric matrix protein	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d3v2qd_	Coiled coil proteins	Parallel coiled-coil	Assembly domain of cartilage oligomeric matrix protein	Assembly domain of cartilage oligomeric matrix protein	Assembly domain of cartilage oligomeric matrix protein	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d3v2qe_	Coiled coil proteins	Parallel coiled-coil	Assembly domain of cartilage oligomeric matrix protein	Assembly domain of cartilage oligomeric matrix protein	Assembly domain of cartilage oligomeric matrix protein	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d3v2qa_	Coiled coil proteins	Parallel coiled-coil	Assembly domain of cartilage oligomeric matrix protein	Assembly domain of cartilage oligomeric matrix protein	Assembly domain of cartilage oligomeric matrix protein	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Assembly domain of cartilage oligomeric matrix protein	8080331	3001466	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Assembly domain of cartilage oligomeric matrix protein	8080331	3001466	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Assembly domain of cartilage oligomeric matrix protein	8080331	3001466	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Assembly domain of cartilage oligomeric matrix protein	8080331	3001466	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Assembly domain of cartilage oligomeric matrix protein	8080331	3001466	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.5.10	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	1.20.5.10	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
D	1.20.5.10	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
E	1.20.5.10	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A	1.20.5.10	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF11598	Cartilage oligomeric matrix protein (COMP)	Cartilage oligomeric matrix protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Cartilage Oligomerization matrix protein (coiled-coil domain)	vitamin binding binding organic cyclic compound binding vitamin D binding steroid binding lipid binding small molecule binding BMP binding protein binding cytokine binding fibronectin binding heparan sulfate proteoglycan binding proteoglycan binding carbohydrate derivative binding vitamin binding binding organic cyclic compound binding vitamin D binding steroid binding lipid binding small molecule binding BMP binding protein binding cytokine binding fibronectin binding heparan sulfate proteoglycan binding proteoglycan binding carbohydrate derivative binding sulfur compound binding cation binding ion binding calcium ion binding metal ion binding enzyme binding protease binding collagen binding protein-containing complex binding cell adhesion molecule binding integrin binding signaling receptor binding structural molecule activity extracellular matrix structural constituent heparin binding glycosaminoglycan binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development developmental growth endochondral bone morphogenesis organ growth growth plate cartilage development developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development developmental growth endochondral bone morphogenesis organ growth growth plate cartilage development endochondral bone growth animal organ morphogenesis bone development growth anatomical structure morphogenesis bone growth skeletal system morphogenesis cartilage development involved in endochondral bone morphogenesis bone morphogenesis regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding negative regulation of hemostasis regulation of biological process negative regulation of biological process regulation of hemostasis ossification bone mineralization biomineral tissue development cellular developmental process cell development cell differentiation chondrocyte differentiation cellular process chondrocyte development response to organic substance response to topologically incorrect protein response to chemical response to unfolded protein regulation of biosynthetic process regulation of cellular process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process apoptotic process cell death programmed cell death homotypic cell-cell adhesion cell activation platelet aggregation cell adhesion cell-cell adhesion platelet activation blood vessel morphogenesis tube development artery development vasculature development circulatory system development tube morphogenesis artery morphogenesis blood vessel development cellular response to stimulus cellular response to stress cellular senescence system process nervous system process neuromuscular process cellular component organization collagen fibril organization extracellular matrix organization cellular component organization or biogenesis supramolecular fiber organization extracellular structure organization external encapsulating structure organization regulation of multicellular organismal development regulation of developmental process regulation of biomineral tissue development regulation of bone mineralization regulation of multicellular organismal process regulation of ossification cell population proliferation chondrocyte proliferation positive regulation of cell population proliferation positive regulation of biological process positive regulation of chondrocyte proliferation regulation of cell population proliferation positive regulation of cellular process limb development appendage development protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region localization secretion by cell protein transport cellular macromolecule localization macromolecule localization muscle structure development muscle cell development muscle cell differentiation multicellular organism growth tendon development cellular response to BMP stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus cell communication cellular response to endogenous stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway signal transduction response to growth factor BMP signaling pathway enzyme-linked receptor protein signaling pathway skin development negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process smooth muscle cell differentiation vascular associated smooth muscle cell differentiation vascular associated smooth muscle cell development organonitrogen compound metabolic process primary metabolic process protein maturation proteolysis protein processing protein metabolic process multicellular organismal movement musculoskeletal movement regulation of tube diameter vascular associated smooth muscle contraction regulation of tube size muscle contraction muscle system process circulatory system process smooth muscle contraction vascular process in circulatory system blood vessel diameter maintenance vasoconstriction blood circulation regulation of anatomical structure size multicellular organismal-level homeostasis homeostatic process cartilage homeostasis anatomical structure homeostasis tissue homeostasis cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization	cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity extracellular region extracellular space protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR017897	Thrombospondin, type 3 repeat	Repeat
A, B, C, D, E	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A, B, C, D, E	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR024665	Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain	Domain
A, B, C, D, E	IPR003367	Thrombospondin, type 3-like repeat	Repeat
A, B, C, D, E	IPR001881	EGF-like calcium-binding domain	Domain
A, B, C, D, E	IPR008859	Thrombospondin, C-terminal	Domain
A, B, C, D, E	IPR028974	TSP type-3 repeat	Homologous Superfamily
A, B, C, D, E	IPR000742	EGF-like domain	Domain
A, B, C, D, E	IPR039081	Thrombospondin-5, coiled coil domain	Domain
A, B, C, D, E	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR046970	Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.