Annotations: 3V11

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8056814	3002022	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	EF-Tu post-G domain-like	8056815	3002024	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	EF-Tu post-G domain-like	8056817	3002024	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	eIF2alpha middle domain-like	8037022	3001761	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	eIF-2-alpha C-terminal domain	8036122	3001618	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleic acid-binding proteins	8037024	3000135	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3v11A4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF09173	e3v11A1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Aminomethyltransferase beta-barrel domain	F: PF09173	ECOD (1.6)
A	PF00009	e3v11A2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00009	ECOD (1.6)
A	F_UNCLASSIFIED	e3v11A3	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00575	e3v11B6	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF00575	ECOD (1.6)
B	PF07541	e3v11B4	A: alpha arrays	X: HhH/H2TH	H: eIF2alpha middle domain (From Topology)	T: eIF2alpha middle domain	F: PF07541	ECOD (1.6)
B	PF07541	e3v11B5	A: a+b two layers	X: Alpha-beta plaits	H: eIF-2-alpha, C-terminal domain (From Topology)	T: eIF-2-alpha, C-terminal domain	F: PF07541	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00009	Elongation factor Tu GTP binding domain (GTP_EFTU)	Elongation factor Tu GTP binding domain	This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.	Domain
A	PF09173	Initiation factor eIF2 gamma, C terminal (eIF2_C)	Initiation factor eIF2 gamma, C terminal	Members of this family, which are found in the initiation factors eIF2 and EF-Tu, adopt a structure consisting of a beta barrel with Greek key topology. They are required for formation of the ternary complex with GTP and initiator tRNA [1].	Domain
B	PF07541	Eukaryotic translation initiation factor 2 alpha subunit (EIF_2_alpha)	Eukaryotic translation initiation factor 2 alpha subunit	-	Family
B	PF00575	S1 RNA binding domain (S1)	S1 RNA binding domain	The S1 domain occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure.	Domain
C	PF01873	Domain found in IF2B/IF5 (eIF-5_eIF-2B)	Domain found in IF2B/IF5	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Translation initiation factor 2 subunit gamma	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding translation elongation factor activity RNA binding tRNA binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding translation elongation factor activity RNA binding tRNA binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	ribonucleoprotein complex biogenesis cellular biosynthetic process organonitrogen compound biosynthetic process protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process translational initiation cellular component organization or biogenesis protein metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process organonitrogen compound biosynthetic process protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process translational initiation cellular component organization or biogenesis protein metabolic process formation of translation preinitiation complex organonitrogen compound metabolic process protein-containing complex organization cellular metabolic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process cytoplasmic translation cellular process cytoplasmic translational initiation metabolic process macromolecule metabolic process	-
B	Translation initiation factor 2 subunit alpha	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding RNA binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process	-
C	Translation initiation factor 2 subunit beta	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding	ribonucleoprotein complex biogenesis cellular biosynthetic process organonitrogen compound biosynthetic process protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process translational initiation cellular component organization or biogenesis protein metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process organonitrogen compound biosynthetic process protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process translational initiation cellular component organization or biogenesis protein metabolic process formation of translation preinitiation complex organonitrogen compound metabolic process protein-containing complex organization cellular metabolic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process cytoplasmic translation cellular process cytoplasmic translational initiation metabolic process macromolecule metabolic process formation of cytoplasmic translation initiation complex	-
D	Initiator tRNA	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR022424	Translation initiation factor 2, gamma subunit	Family
A	IPR000795	Translational (tr)-type GTP-binding domain	Domain
A	IPR009001	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal	Homologous Superfamily
A	IPR044128	Initiation factor eIF2 gamma, GTP-binding domain	Domain
A	IPR015256	Initiation factor eIF2 gamma, C-terminal	Domain
A	IPR009000	Translation protein, beta-barrel domain superfamily	Homologous Superfamily
A	IPR005225	Small GTP-binding protein domain	Domain
A	IPR044127	Initiation factor eIF2 gamma, domain 2	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR003029	S1 domain	Domain
B	IPR044126	IF2a, S1-like domain	Domain
B	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B	IPR024055	Translation initiation factor 2, alpha subunit, C-terminal	Homologous Superfamily
B	IPR024054	Translation initiation factor 2, alpha subunit, middle domain superfamily	Homologous Superfamily
B	IPR011488	Translation initiation factor 2, alpha subunit	Family
B	IPR022964	Translation initiation factor 2, alpha subunit, archaeal	Family
C	IPR016190	Translation initiation factor IF2/IF5, zinc-binding	Homologous Superfamily
C	IPR002735	Translation initiation factor IF2/IF5 domain	Domain
C	IPR016189	Translation initiation factor IF2/IF5, N-terminal	Homologous Superfamily
C	IPR004458	Translation initiation factor 2, beta subunit	Family
C	IPR045196	Translation initiation factor IF2/IF5	Family